Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ivan Shpylchak"'
Autor:
Sergei Nikonov, Puya Aravand, Arkady Lyubarsky, Roman Nikonov, Angela J. Luo, Zhangyong Wei, Albert M. Maguire, Nicholas T. Phelps, Ivan Shpylchak, Keirnan Willett, Tomas S. Aleman, Rachel M. Huckfeldt, Pavitra S. Ramachandran, Jean Bennett
Publikováno v:
Translational vision sciencetechnology. 11(5)
Optogenetic gene therapy to render remaining retinal cells light-sensitive in end-stage retinal degeneration is a promising strategy for treatment of individuals blind because of a variety of different inherited retinal degenerations. The clinical tr
Autor:
Ivan Shpylchak, Vidyullatha Vasireddy, Katherine E. Uyhazi, Denise J. Pearson, Zhangyong Wei, Jean Bennett, Lanfranco Leo, Leona W. Serrano, Puya Aravand, Tomas S. Aleman, Brent A. Bell, Jennifer Pham
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To determine the therapeutic window for gene augmentation for Leber congenital amaurosis (LCA) associated with mutations in LCA5. Methods Five patients (ages 6-31) with LCA and biallelic LCA5 mutations underwent an ophthalmic examination incl
Autor:
Patsy M. Nishina, Jeannette L. Bennicelli, Jieyan Pan, Ji Yun Song, Frans P.M. Cremers, Tomas S. Aleman, Ilan McNamara, Shangzhen Zhou, Gui-Shuang Ying, Junwei Sun, Lanfranco Leo, Puya Aravand, Pamela S. Herrera, Arkady Lyubarsky, Ivan Shpylchak, Zhangyong Wei, Albert M. Maguire, Sergei Nikonov, Jennifer Pham, Robert K. Koenekoop, Wei Pan, Daniel J Bennett, Ronald Roepman, Jimmy de Melo, Jason A. Mills, Nicoletta Commins, Anneke I. den Hollander, Jean Bennett
Publikováno v:
Molecular Therapy, 26, 1581-1593
Molecular Therapy, 26, 6, pp. 1581-1593
Molecular Therapy, 26, 6, pp. 1581-1593
Item does not contain fulltext Most genetically distinct inherited retinal degenerations are primary photoreceptor degenerations. We selected a severe early onset form of Leber congenital amaurosis (LCA), caused by mutations in the gene LCA5, in orde
Autor:
Theodore G. Drivas, Mitchell Lewis, Thu T. Duong, Ivan Shpylchak, Jean Bennett, Jeannette L. Bennicelli, Adam Wojno, Matthew A. Sochor, Vidyullatha Vasireddy, Daniel C. Chung
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports
Scientific Reports
The future of treating inherited and acquired genetic diseases will be defined by our ability to introduce transgenes into cells and restore normal physiology. Here we describe an autogenous transgene regulatory system (ARES), based on the bacterial
Autor:
Ivan Shpylchak, Thu Doung, Daniel C. Chung, Vidyullatha Vasireddy, Mitchell Lewis, Matthew A. Sochor, Adam Wojno, Theodore G. Drivas, Jeannette L. Bennicelli, Jean Bennett
Publikováno v:
Scientific Reports
The future of treating inherited and acquired genetic diseases will be defined by our ability to introduce transgenes into cells and restore normal physiology. Here we describe an autogenous transgene regulatory system (ARES), based on the bacterial