Výsledky vyhledávání - "Ivan S. Pires"

Akademický článek

Toxic side-effects of diaspirin cross-linked human hemoglobin are attenuated by the apohemoglobin-haptoglobin complex

Autor: Carlos J. Munoz, Daniela Lucas, Jacinda Martinez, Mia Ricario, Quintin T. O'Boyle, Ivan S. Pires, Andre F. Palmer, Pedro Cabrales

Publikováno v: Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116569- (2024)

Alpha-alpha diaspirin-crosslinked human hemoglobin (DCLHb or ααHb) was a promising early generation red blood cell (RBC) substitute. The DCLHb was developed through a collaborative effort between the United States Army and Baxter Healthcare. The co

Externí odkaz: https://doaj.org/article/56fb0c0c15a04929bbd507e481d79631

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Akademický článek

Synergistic combination therapy delivered via layer‐by‐layer nanoparticles induces solid tumor regression of ovarian cancer

Autor: Stephanie Kong, Pearl Moharil, Abram Handly‐Santana, Natalie Boehnke, Richard Panayiotou, Victoria Gomerdinger, Gil Covarrubias, Ivan S. Pires, Ioannis Zervantonakis, Joan Brugge, Paula T. Hammond

Publikováno v: Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)

Abstract The majority of patients with high grade serous ovarian cancer (HGSOC) develop recurrent disease and chemotherapy resistance. To identify drug combinations that would be effective in treatment of chemotherapy resistant disease, we examined t

Externí odkaz: https://doaj.org/article/0fdb0c64b4324a05901ffd1980280b58

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Akademický článek

Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors

Autor: Antonio E. Barberio, Sean G. Smith, Ivan S. Pires, Sonia Iyer, Ferenc Reinhardt, Mariane B. Melo, Heikyung Suh, Robert A. Weinberg, Darrell J. Irvine, Paula T. Hammond

Publikováno v: Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)

Abstract Ovarian cancer is especially deadly, challenging to treat, and has proven refractory to known immunotherapies. Cytokine therapy is an attractive strategy to drive a proinflammatory immune response in immunologically cold tumors such as many

Externí odkaz: https://doaj.org/article/da7a5559c1a94ad19eb3527ed8b1cd25

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Akademický článek

Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme

Autor: Carlos J. Munoz, Ivan S. Pires, Vinay Jani, Srila Gopal, Andre F. Palmer, Pedro Cabrales

Publikováno v: Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113911- (2022)

β-thalassemia is a genetic hemoglobin (Hb) disorder that affects millions of people world-wide. It is characterized by ineffective erythropoiesis and anemia. The resultant chronic anemia can require life-long blood transfusion regimens, leading to s

Externí odkaz: https://doaj.org/article/de54c08cc9264bf6be40b1ef68b4eed6

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