Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ivan S. Kondratov"'
Autor:
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostagl
Externí odkaz:
https://doaj.org/article/5afef5b1703241589164379113e645d4
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 19, Iss 1, Pp 3-9 (2021)
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry. Results and discussion. 4-(
Externí odkaz:
https://doaj.org/article/b53720b462db4c03b6498ead4e11fa30
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 18, Iss 3, Pp 55-59 (2020)
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA). Results and discussion. α,α-Difluoro-γ-am
Externí odkaz:
https://doaj.org/article/c99ce1ac30ca4cbc8e0b2d677ec98425
Publikováno v:
ACS Medicinal Chemistry Letters. 13:992-996
Ukrainian companies occupy an important niche in the global drug discovery process; however, before the Russian invasion, the role of Ukraine was not obvious. The biggest Ukrainian fine chemical supplier, Enamine Ltd, had to stop operation for more t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f2f0a75c950754318f14bed0fe40f8
https://doi.org/10.1021/acsmedchemlett.2c00211
https://doi.org/10.1021/acsmedchemlett.2c00211
Challenges for chemistry in Ukraine after the war: Ukrainian science requires rebuilding and support
Autor:
Ivan S. Kondratov, Yurii S. Moroz, Christoph Gorgulla, Oleksandr O. Grygorenko, Igor V. Komarov, Gerhard Wagner, Andrey A. Tolmachev
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(50)
The unprovoked Russian invasion has created considerable challenges for Ukrainian science. In this article, we discuss actions needed to support and rebuild Ukrainian science and educational systems. The proposed actions take into account past Ukrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b80994c81bc5b3e9862f9de8034cd26
https://pubmed.ncbi.nlm.nih.gov/36472958
https://pubmed.ncbi.nlm.nih.gov/36472958
Autor:
Anton V. Chernykh, Danylo Aloshyn, Yuliya O. Kuchkovska, Constantin G. Daniliuc, Nataliya A. Tolmachova, Ivan S. Kondratov, Sergey Zozulya, Oleksandr O. Grygorenko, Günter Haufe
Publikováno v:
Organicbiomolecular chemistry. 20(47)
The synthesis of all enantiopure N-Boc-protected β-CF3- and β-C2F5-prolines and the stability of their model dipeptide derivatives towards proteolytic degradation are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd70fee7d1a18113081b1b0c15b2584
https://pubmed.ncbi.nlm.nih.gov/36107003
https://pubmed.ncbi.nlm.nih.gov/36107003
Autor:
Oleksandr V. Hryshchuk, Igor I. Gerus, Constantin G. Daniliuc, Oleg M. Michurin, Olha V. Mykhailenko, Volodymyr O. Kovtunenko, Oleksandr O. Grygorenko, Bohdan V. Vashchenko, Kostiantyn P. Melnykov, Anton A. Homon, Ivan S. Kondratov
Publikováno v:
European Journal of Organic Chemistry. 2021:6580-6590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a8e6a85291325d615ff01e99a9c2b3
https://doi.org/10.1002/ejoc.202100414
https://doi.org/10.1002/ejoc.202100414
Autor:
Elissa A. Fink, Conner Bardine, Stefan Gahbauer, Isha Singh, Kris White, Shuo Gu, Xiaobo Wan, Beatrice Ary, Isabella Glenn, Joseph O’Connell, Henry O’Donnell, Pavla Fajtová, Jiankun Lyu, Seth Vigneron, Nicholas J. Young, Ivan S. Kondratov, Anthony J. O’Donoghue, Yurii Moroz, Jack Taunton, Adam R. Renslo, John J. Irwin, Adolfo García-Sastre, Brian K. Shoichet, Charles S. Craik
Antiviral therapeutics to treat SARS-CoV-2 are much desired for the on-going pandemic. A well-precedented viral enzyme is the main protease (MPro), which is now targeted by an approved drug and by several investigational drugs. With the inevitable li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a54cce0adbd99c2d1934399aea5fb9c
https://doi.org/10.1101/2022.07.05.498881
https://doi.org/10.1101/2022.07.05.498881
Autor:
Illia O. Feskov, Vasyl S. Naumchyk, Ivan S. Kondratov, Oleksandra Onopchenko, Oleksandr O. Grygorenko, Yu. O. Kuchkovska
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 18, Iss 4(72), Pp 14-22 (2020)
Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e0530bf87977325f8788431e8382e
http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383
http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383
Autor:
Oleksandr O. Grygorenko, Ivan S. Kondratov, Illia O. Feskov, Bohdan V. Vashchenko, Günter Haufe, Bohdan O. Golub, Vadym V. Levterov
Publikováno v:
European Journal of Organic Chemistry. 2020:4755-4767
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d4d95d95b52748d8c0085de76360ef
https://doi.org/10.1002/ejoc.202000733
https://doi.org/10.1002/ejoc.202000733