Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ivan Richards"'
Autor:
Gareth D Healey, Jennifer A Lockridge, Shawn Zinnen, Julian M Hopkin, Ivan Richards, William Walker
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90338 (2014)
Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. H
Externí odkaz:
https://doaj.org/article/e47efed6893641499d5f6df141f92191
Autor:
Karl Kossen, Toshiyuki Koya, Erwin W. Gelfand, Barry Polisky, Joseph J. Lucas, Shawn Zinnen, Tricia N. Lively, Ivan Richards, Annette Balhorn, Katsuyuki Takeda
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background RNA interference is an endogenous cellular mechanism in which short interfering RNAs (siRNAs) direct the sequence specific degradation of a target mRNA. siRNAs can be synthesized with chemical modifications to increase stability and reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977240a92dac71c8041fe1b55f14258f
https://doi.org/10.1016/j.jaci.2007.08.029
https://doi.org/10.1016/j.jaci.2007.08.029
Autor:
William Walker, Julian M. Hopkin, Jennifer A. Lockridge, Gareth D. Healey, Shawn Zinnen, Ivan Richards
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90338 (2014)
PLoS ONE
PLoS ONE
Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecde221bde224935623bd368fe05623
http://europepmc.org/articles/PMC3937390?pdf=render
http://europepmc.org/articles/PMC3937390?pdf=render
Autor:
Gareth D, Healey, Shawn, Zinnen, Jennifer A, Lockridge, Ivan, Richards, Neil, Evans, William, Walker
Publikováno v:
Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research
The interleukin (IL)-13 pathway and its associated transcription factor, signal transducer and activator of transcription 6 (STAT6), have been clearly implicated in the pathogenesis of bronchial asthma. We have developed a system to effectively scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b5fd53ffc728228a64804596852e5b8
https://pubmed.ncbi.nlm.nih.gov/20927184
https://pubmed.ncbi.nlm.nih.gov/20927184
Autor:
Tongqian Chen, David K. Tung, Kim Hartsough, Sharon Jamison, Ivan Richards, Anna M. Gomez, Brent A. Dickinson, Weimin Wang, Chandra Vargeese, Tim R. Shadel, Christine L. Wohlford-Lenane, Pam A. Pavco, Jennifer A. Lockridge, Paul B. McCray
Publikováno v:
Molecular Therapy. 13:S271
RNA interference using synthetic siRNAs to inhibit gene expression in a sequence-specific manner offers a novel opportunity for treating pulmonary diseases including asthma, airway inflammation, and respiratory viral infections. Developing siRNAs as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462034b0f75b57e8b7ba6819ce608f8a
https://doi.org/10.1016/j.ymthe.2006.08.778
https://doi.org/10.1016/j.ymthe.2006.08.778
Publikováno v:
Journal of Allergy and Clinical Immunology. 75:143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40baa4249e36e6dd9a45816d1103cf1a
https://doi.org/10.1016/0091-6749(85)90291-x
https://doi.org/10.1016/0091-6749(85)90291-x