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Akademický článek

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules.

Autor: Guang Gao, Chengjia Zhu, Emma Liu, Ivan R Nabi

Publikováno v: PLoS Biology, Vol 17, Iss 8, p e3000355 (2019)

The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and rough, ribosome-studded central ER sheets whose morphology is determined, in part, by the ER-shaping proteins, reticulon (RTN) and c

Externí odkaz: https://doaj.org/article/2c1842262266435a961fa40fed167bee

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Akademický článek

Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents.

Autor: Anastasia Hyrina, Fanrui Meng, Steven J McArthur, Sharlene Eivemark, Ivan R Nabi, François Jean

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174483 (2017)

Viral hijacking and manipulation of host-cell biosynthetic pathways by human enveloped viruses are shared molecular events essential for the viral lifecycle. For Flaviviridae members such as hepatitis C virus and dengue virus (DENV), one of the key s

Externí odkaz: https://doaj.org/article/8fe6c0fce4544b1483d51d5be61ebc0d

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Akademický článek

Correction: Actin Cytoskeleton Regulation of Epithelial Mesenchymal Transition in Metastatic Cancer Cells.

Autor: Jay Shankar, Ivan R Nabi

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132759 (2015)

[This corrects the article DOI: 10.1371/journal.pone.0119954.].

Externí odkaz: https://doaj.org/article/5dac77e48bad4498924513ae34e59b97

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Akademický článek

Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells.

Autor: Jay Shankar, Ivan R Nabi

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119954 (2015)

Epithelial-mesenchymal transition (EMT) is associated with loss of the cell-cell adhesion molecule E-cadherin and disruption of cell-cell junctions as well as with acquisition of migratory properties including reorganization of the actin cytoskeleton

Externí odkaz: https://doaj.org/article/10976116972049ab992ab62957afe3e5

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Akademický článek

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

Autor: Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7124 (2009)

BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. A

Externí odkaz: https://doaj.org/article/647f3f277aad48c4b8c4c845abe65350

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Akademický článek

Raft-dependent endocytosis of autocrine motility factor/phosphoglucose isomerase: a potential drug delivery route for tumor cells.

Autor: Liliana D Kojic, Sam M Wiseman, Fariba Ghaidi, Bharat Joshi, Hinyu Nedev, H Uri Saragovi, Ivan R Nabi

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3597 (2008)

Autocrine motility factor/phosphoglucose isomerase (AMF/PGI) is the extracellular ligand for the gp78/AMFR receptor overexpressed in a variety of human cancers. We showed previously that raft-dependent internalization of AMF/PGI is elevated in metast

Externí odkaz: https://doaj.org/article/2d0956353d504cb8bc55f4f52ecc493f

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