Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ivan Plavec"'
Autor:
Andrew C Melton, Jennifer Melrose, Liisa Alajoki, Sylvie Privat, Hannah Cho, Naomi Brown, Ana Marija Plavec, Dat Nguyen, Elijah D Johnston, Jian Yang, Mark A Polokoff, Ivan Plavec, Ellen L Berg, Alison O'Mahony
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58966 (2013)
Improper regulation of B cell responses leads to excessive production of antibodies and contributes to the development of autoimmune disease. T helper 17 (Th17) cells also drive the development of autoimmune disease, but the role of B cells in shapin
Externí odkaz:
https://doaj.org/article/b2a1465f63034f5fb3cebec00bc94e27
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 53:67-74
Introduction Unexpected drug activities account for many of the failures of new chemical entities in clinical trials. These activities can be target-dependent, resulting from feedback mechanisms downstream of the primary target, or they can occur as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c776f41e91c6fd1130130f98b20a942b
https://doi.org/10.1016/j.vascn.2005.06.003
https://doi.org/10.1016/j.vascn.2005.06.003
Autor:
Evangelos Hytopoulos, Eric J. Kunkel, Eugene C. Butcher, Dat Nguyen, Anthony C. Bishop, Ivan Plavec, Raynard L. Bateman, Leon T. Kao, Yuker Wang, Elen S. Rosler, Jennifer Melrose, Kevan M. Shokat, Ellen L. Berg
Publikováno v:
ASSAY and Drug Development Technologies. 2:431-442
Rapid, quantitative methods for characterizing the biological activities of kinase inhibitors in complex human cell systems could allow the biological consequences of differential target selectivity to be monitored early in development, improving the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcefb45349a68522e18f3523fdb4f76
https://doi.org/10.1089/adt.2004.2.431
https://doi.org/10.1089/adt.2004.2.431
Autor:
Stanley R. Riddell, Laurence J.N. Cooper, Max S. Topp, Ivan Plavec, Michael C. Jensen, Cris Pinzon, Philip D. Greenberg
Publikováno v:
Human Gene Therapy. 15:648-658
The level of expression of retroviral vector-encoded proteins in T cells, decreasing during periods of quiescence, could be an obstacle to their clinical utility. To identify promoter systems that could increase the strength and persistence of transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c9384435dde9e3d9801f050c04425c
https://doi.org/10.1089/1043034041361217
https://doi.org/10.1089/1043034041361217
Autor:
Robert D. Berkowitz, Wei Yu Lin, Stan Tamaki, Gabor Veres, Andrea Coward, Karl Eckert, Heini Ilves, Ivan Plavec
Publikováno v:
Journal of Virology. 75:3371-3382
Because lentiviruses are able to infect nondividing cells, these viruses might be utilized in gene therapy applications where the target cell does not divide. However, it has been suggested that the introduction of primate lentivirus sequences, parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6633fa93701778d994fc89d3152fa57
https://doi.org/10.1128/jvi.75.7.3371-3382.2001
https://doi.org/10.1128/jvi.75.7.3371-3382.2001
Publikováno v:
Virology. 279(1):116-129
Efficient transfer of therapeutic genes into nondividing human cells can be accomplished by inserting the genes into lentiviruses and infecting the cells with the modified viruses. The most developed lentivirus gene transfer systems are based on HIV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed874cd12f47545818864e0996f9da8c
Autor:
L J Murray, Beth L Hill, Marilyn Travis, Ivan Plavec, E. G. Hanania, Katherine Olsson, Karin Luens-Abitorabi, Sean P. Forestell
Publikováno v:
Human Gene Therapy. 11:2039-2050
Absence of durable high-level expression of transgenes from Moloney murine leukemia (Mo-MuLV) retroviral vectors has been a hurdle in bringing effective gene therapy to the clinic. In this study we have analyzed transgene expression among the progeny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdde188ed50cfefad9eef640e4b1f1dd
https://doi.org/10.1089/10430340050143453
https://doi.org/10.1089/10430340050143453
Publikováno v:
Human Gene Therapy. 10:2779-2787
We have used a mouse bone marrow transplantation (BMT) model to study the safety of retrovirus-mediated transfer of anti-HIV genes (RevM10 and HIV-1 pol antisense) into hematopoietic stem/progenitor cells (HSPCs). In particular, we have monitored the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c923ec34ccf7ec3d7dc3ddd6bbf9ce
https://doi.org/10.1089/10430349950016519
https://doi.org/10.1089/10430349950016519
Publikováno v:
Human Gene Therapy. 10:1389-1399
The scaffold attachment region of the human interferon beta gene (IFN-SAR) inserted into a retroviral vector improved transgene expression in human primary CD4+ and CD8+ T cells, and in primary monocytemacrophages. In T cells, expression of the Malon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4564898cbc777356b2f86c6787a506
https://doi.org/10.1089/10430349950018058
https://doi.org/10.1089/10430349950018058
Autor:
Fiona McPhee, J R Rosé, Uwe Junker, Ivan Plavec, Sonia Escaich, E Böhnlein, Charles S. Craik, J Baker
Publikováno v:
Journal of Virology. 70:7765-7772
The enzymatic activity of the human immunodeficiency type 1 (HIV-1) protease (PR) is crucial to render HIV-1 virions mature and infectious. Hence, genetic intervention strategies based on trans-dominant (td) variants of the HIV-1 PR might be an alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18934d94adefb79f13f1b093b42aaa2
https://doi.org/10.1128/jvi.70.11.7765-7772.1996
https://doi.org/10.1128/jvi.70.11.7765-7772.1996