Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ivan Petushkov"'
Autor:
Polina Kamzeeva, Ivan Petushkov, Ekaterina Knizhnik, Robert Snoeck, Yuri Khodarovich, Ekaterina Ryabukhina, Vera Alferova, Artur Eshtukov-Shcheglov, Evgeny Belyaev, Julia Svetlova, Tatiana Vedekhina, Andrey Kulbachinskiy, Anna Varizhuk, Graciela Andrei, Andrey Aralov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14540 (2023)
Emerging and re-emerging viruses periodically cause outbreaks and epidemics around the world, which ultimately lead to global events such as the COVID-19 pandemic. Thus, the urgent need for new antiviral drugs is obvious. Over more than a century of
Externí odkaz:
https://doaj.org/article/c59dd755343042d3bde6f4d7c7cf236f
Autor:
Elena Matyugina, Ivan Petushkov, Sergei Surzhikov, Vasily Kezin, Anna Maslova, Olga Ivanova, Olga Smirnova, Ilya Kirillov, Irina Fedyakina, Andrey Kulbachinskiy, Sergey Kochetkov, Anastasia Khandazhinskaya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3361 (2023)
The SARS-CoV-2 betacoronavirus pandemic has claimed more than 6.5 million lives and, despite the development and use of COVID-19 vaccines, remains a major global public health problem. The development of specific drugs for the treatment of this disea
Externí odkaz:
https://doaj.org/article/4305aeb0db2e468789bf9d0226265656
Autor:
David Dulin, David L. V. Bauer, Anssi M. Malinen, Jacob J. W. Bakermans, Martin Kaller, Zakia Morichaud, Ivan Petushkov, Martin Depken, Konstantin Brodolin, Andrey Kulbachinskiy, Achillefs N. Kapanidis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
RNA synthesis by bacterial RNA polymerase is interrupted by pauses but their role in RNA synthesis is poorly understood. Here the authors use single-molecule FRET and biochemical analysis to show that pausing regulates branching between the abortive
Externí odkaz:
https://doaj.org/article/5a7bdeadb61d4f6d961109f5e5564849
Autor:
Nataliya Miropolskaya, Maxim Kozlov, Ivan Petushkov, Maria Prostova, Danil Pupov, Daria Esyunina, Sergey Kochetkov, Andrey Kulbachinskiy
Publikováno v:
Biochimie.
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is the key enzyme required for viral replication and mRNA synthesis. RdRp is one of the most conserved viral proteins and a promising target for antiviral drugs and inhibitors. At the same time, analysis
Publikováno v:
The FEBS journalReferences. 290(1)
RNA-dependent RNA polymerase (RdRp) plays a key role in the replication of RNA viruses, including SARS-CoV-2. Processive RNA synthesis by RdRp is crucial for successful genome replication and expression, especially in the case of very long coronavira
Publikováno v:
RNA Biol
The bacterial σ factor plays the central role in promoter recognition by RNA polymerase (RNAP). The primary σ factor, involved in transcription of housekeeping genes, was also shown to participate in the initiation of RNA synthesis and promoter esc
Autor:
Mikhail V. Nesterchuk, P. I. Pletnev, Lizaveta Pshanichnaya, Petr V. Sergiev, Andrey Kulbachinskiy, M. P. Rubtsova, Andrey V. Mardanov, Danil Pupov, Olga A. Dontsova, Daria Esyunina, Nikolai V. Ravin, Ilya A. Osterman, Ivan Petushkov
Publikováno v:
Nucleic Acids Research
In bacteria, rapid adaptation to changing environmental conditions depends on the interplay between housekeeping and alternative σ factors, responsible for transcription of specific regulons by RNA polymerase (RNAP). In comparison with alternative
Publikováno v:
The Journal of biological chemistry. 298(7)
Bacterial RNA polymerase (RNAP) coordinates transcription with DNA repair and replication. Many RNAP mutations have pleiotropic phenotypes with profound effects on transcription-coupled processes. One class of RNAP mutations (rpo∗) has been shown t
Publikováno v:
Biochemistry (Moscow). 84:426-434
The bacterium Escherichia coli has seven σ subunits that bind core RNA polymerase and are necessary for promoter recognition. It was previously shown that the σ70 and σ38 subunits can also interact with the transcription elongation complex (TEC) a
In contrast to eukaryotic Argonaute proteins that act on RNA targets, prokaryotic Argonautes (pAgos) can target DNA, using either small RNA or small DNA guides for its recognition. Since pAgos can recognize only a single strand of DNA and lack a heli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fe3942614494fe126ba3aa02828557
https://resolver.caltech.edu/CaltechAUTHORS:20201027-090926979
https://resolver.caltech.edu/CaltechAUTHORS:20201027-090926979