Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ivan Nicola Colaluca"'
Autor:
Stefano Confalonieri, Ivan Nicola Colaluca, Andrea Basile, Salvatore Pece, Pier Paolo Di Fiore
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 10, Pp 3359-3367 (2019)
MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is
Externí odkaz:
https://doaj.org/article/1f2bbd0240fc4bffbfd02e38154da38b
Autor:
Maria Grazia Filippone, Stefano Freddi, Silvia Zecchini, Silvia Restelli, Ivan Nicola Colaluca, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Pier Paolo Di Fiore
Publikováno v:
The Journal of cell biology. 221(12)
Asymmetric cell division is a key tumor suppressor mechanism that prevents the uncontrolled expansion of the stem cell (SC) compartment by generating daughter cells with alternative fates: one retains SC identity and enters quiescence and the other b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fc87d75fbb7cff31a9971e78a99f6e
https://pubmed.ncbi.nlm.nih.gov/36200956
https://pubmed.ncbi.nlm.nih.gov/36200956
Autor:
Veronica D'Uva, Valentina Cecatiello, Davide Disalvatore, Andrea Basile, Pier Paolo Di Fiore, Salvatore Pece, Michael Sattler, Lee Freiburger, Daniela Tosoni, Maria Grazia Malabarba, Manuela Vecchi, Stefano Confalonieri, Marina Mapelli, Chun Jiun Yang, Ivan Nicola Colaluca, Masatsune Kainosho
Publikováno v:
'Journal of Cell Biology ', vol: 217, pages: 745-762 (2018)
The Journal of Cell Biology
The Journal of Cell Biology
Numb regulates the activity of the tumor suppressor p53 by inhibiting Mdm2. This study from Colaluca et al. highlights the structural and molecular bases of Numb–Mdm2 interaction and shows how Numb splicing impacts specifically on p53 regulation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4efea2c0917998064b70828be26d88c
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:55443
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:55443
Autor:
Sara Sigismund, Philippe Chavrier, Giorgio Scita, Pier Paolo Di Fiore, Andrea Disanza, Elisa Barbieri, Francesca Senic-Matuglia, Ivan Nicola Colaluca, Stefano Confalonieri, Giusi Caldieri, Michel Franco, Martina Zobel, Sara Bisi, Salvatore Pece
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (9), pp.3161-3182. ⟨10.1083/jcb.201802023⟩
The Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (9), pp.3161-3182. ⟨10.1083/jcb.201802023⟩
The Journal of Cell Biology
How the endocytic protein NUMB modulates mesenchymal migration is unclear. Zobel et al. show that NUMB limits the formation of apically restricted, actin-based protrusions called circular dorsal ruffles (CDRs). NUMB activates the ARF6 guanine nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12593b5f030445e7aee5ca1a2089d9d9
https://hal.archives-ouvertes.fr/hal-02349236/document
https://hal.archives-ouvertes.fr/hal-02349236/document
Autor:
Salvatore Pece, Jessika Wynendaele, Jean-Christophe Marine, Daniela Tosoni, Johan Hoebeke, Rajesh Vyas, Ivan Nicola Colaluca, Robert Amson, Pier Paolo Di Fiore, Sylvie Rodrigues-Ferreira, Giuseppe Viale, Alexandra Lespagnol, Adam Telerman, Giovanni Mazzarol, Olivier Chaloin
Publikováno v:
Nature Medicine
Nature Medicine, Nature Publishing Group, 2012, 18 (1), pp.91-99. ⟨10.1038/nm.2546⟩
Nature Medicine, Nature Publishing Group, 2012, 18 (1), pp.91-99. ⟨10.1038/nm.2546⟩
International audience; Screening for genes that reprogram cancer cells for the tumor reversion switch identified TCTP (encoding translationally controlled tumor protein) as a crucial regulator of apoptosis. Here we report a negative feedback loop be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad2760156353dca02785d9ad981c752
https://doi.org/10.1038/nm.2546
https://doi.org/10.1038/nm.2546
Autor:
Daniela Tosoni, Pier Paolo Di Fiore, Viviana Galimberti, Paolo Nuciforo, Salvatore Pece, Ivan Nicola Colaluca, Francesca Senic-Matuglia, Giuseppe Viale
Publikováno v:
Nature. 451:76-80
NUMB is a cell fate determinant, which, by asymmetrically partitioning at mitosis, controls cell fate choices by antagonising the activity of the plasma membrane receptor of the NOTCH family. NUMB is also an endocytic protein, and the NOTCH-NUMB coun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa9e38f06f7d0c1b0d63a682f3d029d
https://doi.org/10.1038/nature06412
https://doi.org/10.1038/nature06412
Autor:
Maddalena Donzelli, Giovanni Mazzarol, Giovanni D'Ario, Pier Paolo Di Fiore, Daniela Tosoni, Ivan Nicola Colaluca, Sara Volorio, Lorenzo Spaggiari, Giuseppe Viale, Giuseppe Pelosi, Britta Westhoff, Salvatore Pece
Publikováno v:
Proceedings of the National Academy of Sciences
Notch signaling regulates cell specification and homeostasis of stem cell compartments, and it is counteracted by the cell fate determinant Numb. Both Numb and Notch have been implicated in human tumors. Here, we show that Notch signaling is altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4855f1fba8899203f57917aa799e6acd
https://pubmed.ncbi.nlm.nih.gov/20007775
https://pubmed.ncbi.nlm.nih.gov/20007775