Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ivan Molodtsov"'
Autor:
Craig M. Brackett, Kellee F. Greene, Alyssa R. Aldrich, Nicholas H. Trageser, Srabani Pal, Ivan Molodtsov, Bojidar M. Kandar, Lyudmila G. Burdelya, Scott I. Abrams, Andrei V. Gudkov
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as
Externí odkaz:
https://doaj.org/article/b4c8b20a57ee4a1e98fe58a3cedda4f2
Autor:
Natalia Fedtsova, Elena A. Komarova, Kellee F. Greene, Liliya R. Novototskaya, Ivan Molodtsov, Craig M. Brackett, Evguenia Strom, Anatoli S. Gleiberman, Alexander N. Shakhov, Andrei V. Gudkov
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by radiation and/or chemotherapeutic drugs. These genotoxic treatments eliminate host hematop
Externí odkaz:
https://doaj.org/article/567e32f8c63e48f8b13d02edbbb27399
Autor:
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent
Externí odkaz:
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Autor:
Alexey Komissarov, Ivan Molodtsov, Oxana Ivanova, Elena Maryukhnich, Svetlana Kudryavtseva, Alexey Mazus, Evgeniy Nikonov, Elena Vasilieva
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246396 (2021)
Because of the constantly growing numbers of COVID-19 infections and deaths, attempts were undertaken to find drugs with anti-SARS-CoV-2 activity among ones already approved for other pathologies. In the framework of such attempts, in a number of in
Externí odkaz:
https://doaj.org/article/a3fcbbabe6724a699fb834bd161a551f
Autor:
Ksenia A. Novototskaya-Vlasova, Nickolay S. Neznanov, Ivan Molodtsov, Brandon M. Hall, Mairead Commane, Anatoli S. Gleiberman, Jayne Murray, Michelle Haber, Murray D. Norris, Katerina I. Leonova, Andrei V. Gudkov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
Activation of endogenous retrotransposons frequently occurs in cancer cells and contributes to tumor genomic instability. To test whether inhibition of retrotranspositions has an anticancer effect, we used treatment with the nucleoside reverse transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ce780db800bf7e57eabc5db16e5501
https://pubmed.ncbi.nlm.nih.gov/36449545
https://pubmed.ncbi.nlm.nih.gov/36449545
Autor:
Anna Lebedeva, Ivan Molodtsov, Alexandra Anisimova, Anastasia Berestovskaya, Oleg Dukhin, Antonina Elizarova, Wendy Fitzgerald, Darya Fomina, Kseniya Glebova, Oxana Ivanova, Anna Kalinskaya, Anastasia Lebedeva, Maryana Lysenko, Elena Maryukhnich, Elena Misyurina, Denis Protsenko, Alexander Rosin, Olga Sapozhnikova, Denis Sokorev, Alexander Shpektor, Daria Vorobyeva, Elena Vasilieva, Leonid Margolis
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7937
Coronavirus disease 2019 (COVID-19) is characterized by immune activation in response to viral spread, in severe cases leading to the development of cytokine storm syndrome (CSS) and increased mortality. Despite its importance in prognosis, the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5fa54badf2b1e05103964e61658e5f
https://pubmed.ncbi.nlm.nih.gov/35887283
https://pubmed.ncbi.nlm.nih.gov/35887283
Publikováno v:
AIDS
Objective HIV-1 infection triggers immune activation, as reflected by the upregulation of various cytokines. This immune activation remains elevated despite antiretroviral therapy (ART) and leads to early age-related diseases. Here, we addressed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee893c5cd0f66ef325dff7b402cc0333
https://doi.org/10.1097/qad.0000000000002881
https://doi.org/10.1097/qad.0000000000002881
Autor:
Craig M. Brackett, Catherine Burkhart, Ilia Toshkov, Andrei L. Osterman, Ivan A. Bespalov, Andrei Purmal, Vadim L. Mett, Andrei V. Gudkov, Lyudmila G. Burdelya, Yakov N. Kogan, Anatoli S. Gleiberman, Ekaterina L. Andrianova, Ivan Molodtsov, Oleg V. Kurnasov
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including radioprotection and cancer immunotherapy. However, in Phase 1 human studies, entolimod induced a rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdef2dd5c9aac4df928eea9fe09e4c96
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Publikováno v:
J Acquir Immune Defic Syndr
Background Residual immune activation after successful antiretroviral therapy (ART) in HIV-1-infected patients is associated with the increased risk of complications. Cytokines, both soluble and extracellular vesicle (EV)-associated, may play an impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c72f72c4369ca596bc7318b1033314f
https://doi.org/10.1097/qai.0000000000002301
https://doi.org/10.1097/qai.0000000000002301
Autor:
Ivan Molodtsov, Inna V. Dolzhikova, Iuliia O. Peshkova, Elena Vasilieva, Olga Mityaeva, Grigory A. Efimov, Alexey A. Komissarov, Pavel Volchkov, Dmitry V. Shcheblyakov, Nelli B. Naigovzina, Denis Y. Logunov
Despite the measures taken worldwide, COVID-19 pandemic still progresses. While efficient antiviral drugs are not yet widely available, vaccination is the best option to control the infection rate. Although this option is obvious in case of COVID-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ac7749dd84afd64b4940f4317d85c41
https://doi.org/10.1101/2021.10.26.21265531
https://doi.org/10.1101/2021.10.26.21265531
