Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Ivan Mikkelsen"'
1
Carbamoylcholine Homologs: Novel and Potent Agonists at Neuronal Nicotinic Acetylcholine Receptors
Autor: Povl Krogsgaard-Larsen, Bente Frølund, Erik Falch, Anders A. Jensen, Ivan Mikkelsen, Hans Bräuner-Osborne
Publikováno v: Molecular Pharmacology. 64:865-875
The classic muscarinic acetylcholine receptor (mAChR) agonist carbamoylcholine (carbachol) does not seem to be the most obvious lead for the development of selective ligands at nicotinic acetylcholine receptors (nAChRs). In the past, however, N-methy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac94f0b83f722508962403c8a68085a9
https://doi.org/10.1124/mol.64.4.865
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2
Heteroaryl Analogues of AMPA. 2. Synthesis, Absolute Stereochemistry, Photochemistry, and Structure−Activity Relationships
Autor: Povl Krogsgaard-Larsen, Birgitte Nielsen, Bjarke Ebert, Lotte Brehm, Tine B. Stensbøl, Niels Skjærbæk, Tommy N. Johansen, Erik Falch, Ivan Mikkelsen
Publikováno v: Journal of Medicinal Chemistry. 41:2513-2523
We have previously shown that (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA, 2] is a weak agonist at (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptors, specifically activated by (S)-AMPA (1), wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d1ebc891a0e39e0879f5b39d7d03cc
https://doi.org/10.1021/jm9801206
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4
Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer
Autor: Kurt Scudder, Per Arkhammar, Morten Praestegaard, Morten Heide, Viggo Linde, Ivan Mikkelsen, Søren Møller, Frosty Loechel, Robert Terry, Betina Kerstin Lundholt, Søren Jensby Nielsen, Hans-Christian Pedersen, Sara Petersen Bjørn
Publikováno v: Journal of biomolecular screening. 10(1)
The PI3-kinase/Akt pathway is an important cell survival pathway that is deregulated in the majority of human cancers. Despite the apparent druggability of several kinases in the pathway, no specific catalytic inhibitors have been reported in the lit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46b45c5db6197f59830e0119593d7ff
https://pubmed.ncbi.nlm.nih.gov/15695340
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5
Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors
Autor: Bente Frølund, Hans Bräuner-Osborne, Jerzy W. Jaroszewski, Ivan Mikkelsen, Karla Frydenvang, Anders A. Jensen, Povl Krogsgaard-Larsen, Lotte Brehm, Erik Falch
Publikováno v: European journal of pharmacology. 497(2)
In a recent study, racemic 3-(N,N-dimethylamino)butyl-N,N-dimethylcarbamate (1) was shown to be a potent agonist at neuronal nicotinic acetylcholine receptors with a high selectivity for nicotinic over muscarinic acetylcholine receptors [Mol. Pharmac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7fa03694550498f8ae23a27edec57f
https://pubmed.ncbi.nlm.nih.gov/15306197
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6
Analogues of carbacholine: synthesis and relationship between structure and affinity for muscarinic and nicotinic acetylcholine receptors
Autor: Tine B. Stensbøl, Povl Krogsgaard-Larsen, Birgitte Søkilde, Erik Falch, Ivan Mikkelsen, Birgit Andersen, Søren Ebdrup
Publikováno v: Archiv der Pharmazie. 329(2)
A series of acyclic and heterocyclic analogues of carbacholine (1) was synthesized using N-methylcarbacholine (MCC, 2), N,N-dimethylcarbacholine (DMCC, 3), and the corresponding tertiary amine (4) as leads. Whereas nicotinic acetylcholine receptor af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ca53e93067802e8bae21db40e38ca2
https://pubmed.ncbi.nlm.nih.gov/8851473
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