Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Ivan Matic"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Legionella pneumophila (LP) employs the metaeffector SidJ to suppress the toxicity of SdeA and other LP SidE effector family members by catalysing the glutamylation of the catalytic Glu residue. Here, the authors present the cryo-EM structures of Sid
Externí odkaz:
https://doaj.org/article/330293d1384b47d989742f3a1d1d4179
Autor:
Wei-Lin Su, Marie-Florence Bredèche, Sara Dion, Julie Dauverd, Bénédicte Condamine, Arnaud Gutierrez, Erick Denamur, Ivan Matic
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Toxin-antitoxin systems are genetic elements that are widespread in prokaryotes. Although molecular mode of action of many of these toxins has been identified, their biological functions are mostly unknown. We investigated the functional int
Externí odkaz:
https://doaj.org/article/bf75e5540c74485eb37847cf1872a1ae
Autor:
Aurélie Mathieu, Sébastien Fleurier, Antoine Frénoy, Julien Dairou, Marie-Florence Bredeche, Pilar Sanchez-Vizuete, Xiaohu Song, Ivan Matic
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 46-57 (2016)
A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrati
Externí odkaz:
https://doaj.org/article/e59aee2da6df44ca9d46a79ad1c9a5e7
Autor:
Edward Bartlett, Juan José Bonfiglio, Evgeniia Prokhorova, Thomas Colby, Florian Zobel, Ivan Ahel, Ivan Matic
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3488-3502.e5 (2018)
Summary: Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone
Externí odkaz:
https://doaj.org/article/f0809864647342958677be9548b2a375
Publikováno v:
eLife, Vol 7 (2018)
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage
Externí odkaz:
https://doaj.org/article/1585b06cceda46c0884721dc94e68fa4
Publikováno v:
eLife, Vol 6 (2017)
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of A
Externí odkaz:
https://doaj.org/article/4589c1ff47014ade8a4e46ecb6c89bdb
Autor:
Alisa Zhiteneva, Juan Jose Bonfiglio, Alexandr Makarov, Thomas Colby, Paola Vagnarelli, Eric C. Schirmer, Ivan Matic, William C. Earnshaw
Publikováno v:
Open Biology, Vol 7, Iss 9 (2017)
How eukaryotic chromosomes are compacted during mitosis has been a leading question in cell biology since the nineteenth century. Non-histone proteins such as condensin complexes contribute to chromosome shaping, but appear not to be necessary for mi
Externí odkaz:
https://doaj.org/article/ec56b7ce31d64db289ebf27f0d06f770
Publikováno v:
Antibiotics, Vol 2, Iss 1, Pp 100-114 (2013)
Nowadays, the emergence and spread of antibiotic resistance have become an utmost medical and economical problem. It has also become evident that subinhibitory concentrations of antibiotics, which pollute all kind of terrestrial and aquatic environme
Externí odkaz:
https://doaj.org/article/dec02c8395534587bb1a310a0e57c81b
Autor:
Claude Saint-Ruf, Steve Crussard, Christine Franceschi, Sylvain Orenga, Jasmine Outtara, Mahendrasingh Ramjeet, Jeremy Surre, Ivan Matic
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Rapidly treating infections with adequate antibiotics is of major importance. This requires a fast and accurate determination of the antibiotic susceptibility of bacterial pathogens. The most frequently used methods are slow because they are based on
Externí odkaz:
https://doaj.org/article/9b758be6695743419e4e28f4953d5735
Autor:
Emma Lundberg, Linn Fagerberg, Daniel Klevebring, Ivan Matic, Tamar Geiger, Juergen Cox, Cajsa Älgenäs, Joakim Lundeberg, Matthias Mann, Mathias Uhlen
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-9 (2010)
Abstract An essential question in human biology is how cells and tissues differ in gene and protein expression and how these differences delineate specific biological function. Here, we have performed a global analysis of both mRNA and protein levels
Externí odkaz:
https://doaj.org/article/9b71e12be86c41308172823bdb8f9a2d