Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ivan Martinez-Valbuena"'
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106535- (2024)
Background: Multiple system atrophy (MSA) is a primary oligodendroglial synucleinopathy, characterized by elevated iron burden in early-affected subcortical nuclei. Although neurotoxic effects of brain iron deposition and its relationship with α-syn
Externí odkaz:
https://doaj.org/article/7245cad3705c4261b4f9c48b69aabbc0
Autor:
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in fam
Externí odkaz:
https://doaj.org/article/3f5a20111e77431e98b04a082450b8fc
Autor:
Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of
Externí odkaz:
https://doaj.org/article/0a11f0c8776346f5aa6f04e52680ec2e
Autor:
Tomoya Kon, Seojin Lee, Ivan Martinez-Valbuena, Koji Yoshida, Satoshi Tanikawa, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2676 (2024)
Lewy body diseases (LBDs) feature α-synuclein (α-syn)-containing Lewy bodies, with misfolded α-syn potentially propagating as seeds. Using a seeding amplification assay, we previously reported distinct α-syn seeding in LBD cases based on the area
Externí odkaz:
https://doaj.org/article/37ab97b4d1004c5799ef6be1886d237f
Autor:
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy corre
Externí odkaz:
https://doaj.org/article/a8896966164644b4a18d3e1c9d1ee7a0
Autor:
Shojiro Ichimata, Ivan Martinez-Valbuena, Seojin Lee, Jun Li, Ali M. Karakani, Gabor G. Kovacs
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11596 (2023)
Limited comparative data exist on the molecular spectrum of amyloid-beta (Aβ) and tau deposition in individuals with Down syndrome (DS) and sporadic Alzheimer’s disease (sAD). We assessed Aβ and tau deposition severity in the temporal lobe and ce
Externí odkaz:
https://doaj.org/article/6340acf7995646afb892c4688dacf7a9
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 936 (2023)
Recent studies have been able to detect α-synuclein (αSyn) seeding in formaldehyde-fixed paraffin-embedded (FFPE) tissues from patients with synucleinopathies using seed amplification assays (SAAs), but with relatively low sensitivity due to limite
Externí odkaz:
https://doaj.org/article/8667b91cd8224ba8ab4feaddda1414a6
Autor:
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E. Fraser, María-Rosario Luquin
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Protein misfolding diseases refer to a variety of disorders that develop as a consequence of the misfolding of proteins in various organs. The etiologies of Parkinson’s and Alzheimer’s disease remain unclear, but it seems that type two d
Externí odkaz:
https://doaj.org/article/7a977155641c4478bcefd6b211a7b1b5
Publikováno v:
Acta Neuropathologica. 144:1171-1174
Publikováno v:
Biomolecules; Volume 13; Issue 6; Pages: 936
Recent studies have been able to detect α-synuclein (αSyn) seeding in formaldehyde-fixed paraffin-embedded (FFPE) tissues from patients with synucleinopathies using seed amplification assays (SAAs), but with relatively low sensitivity due to limite