Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ivan M, Borrello"'
Autor:
Philip H. Imus, Hua-Ling Tsai, Leo Luznik, Ephraim J. Fuchs, Carol Ann Huff, Douglas E. Gladstone, Patrick Lowery, Richard F. Ambinder, Ivan M. Borrello, Lode J. Swinnen, Nina Wagner-Johnston, Christian B. Gocke, Syed Abbas Ali, F.Javier Bolaños-Meade, Ravi Varadhan, Richard J. Jones
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2608-2616 (2019)
Abstract: Hematologic malignancies in older people are unlikely to be cured with chemotherapy alone. Advances in allogeneic blood or marrow transplantation (alloBMT), especially nonmyeloablative (NMA) conditioning and the use of haploidentical donors
Externí odkaz:
https://doaj.org/article/197de5e065234acea249f8b75efa3cfa
Autor:
Yi Lin, Madhav Dhodapkar, Aaron P Rapoport, Ajai Chari, Nina Shah, Jack Aiello, David E Avigan, Jesus G Berdeja, Ivan M Borrello, Adam D Cohen, Karthik Ganapathi, Lissa Gray, Damian Green, Amrita Krishnan, Elisabet Manasanch, Nikhil C Munshi, Ajay K Nooka, Eric L Smith, Ravi Vij
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Outcomes in multiple myeloma (MM) have improved dramatically in the last two decades with the advent of novel therapies including immunomodulatory agents (IMiDs), proteasome inhibitors and monoclonal antibodies. In recent years, immunotherapy for the
Externí odkaz:
https://doaj.org/article/cfade875c1d0413986d344c84a15d63a
Autor:
Rajani Ravi, Kimberly A. Noonan, Vui Pham, Rishi Bedi, Alex Zhavoronkov, Ivan V. Ozerov, Eugene Makarev, Artem V. Artemov, Piotr T. Wysocki, Ranee Mehra, Sridhar Nimmagadda, Luigi Marchionni, David Sidransky, Ivan M. Borrello, Evgeny Izumchenko, Atul Bedi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Antitumor T cells can be inhibited by a TGFβ rich tumor microenvironment. The authors develop bifunctional proteins comprising CTLA-4 or PD-L1 immune checkpoint-targeted antibodies fused to a “TGFβ trap” and show that they counteract tumor immu
Externí odkaz:
https://doaj.org/article/09ab3fbc9c154b9e985f7d27f5620315
Autor:
Meghali Goswami, Gabrielle Prince, Angelique Biancotto, Susan Moir, Lela Kardava, Brian H. Santich, Foo Cheung, Yuri Kotliarov, Jinguo Chen, Rongye Shi, Huizhi Zhou, Hana Golding, Jody Manischewitz, Lisa King, Lauren M. Kunz, Kimberly Noonan, Ivan M. Borrello, B. Douglas Smith, Christopher S. Hourigan
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background Changes in adaptive immune cells after chemotherapy in adult acute myeloid leukemia (AML) may have implications for the success of immunotherapy. This study was designed to determine the functional capacity of the immune system in
Externí odkaz:
https://doaj.org/article/e65f6c19b08e4388b10594989b666789
Autor:
Jonathan Allen Webster, Madison C. Reed, Hua-Ling Tsai, Alexander J. Ambinder, Tania Jain, Amy E. DeZern, Mark J. Levis, Margaret M. Showel, Gabrielle T. Prince, Christopher S. Hourigan, Javier Bolaños-Meade, Lukasz P. Gondek, Gabriel Ghiaur, William Brian Dalton, Suman Paul, Ephraim J. Fuchs, Christian B. Gocke, Abbas Abbas Ali, Douglas E. Gladstone, Carol Ann Huff, Ivan M. Borrello, Lode J. Swinnen, Nina D. Wagner-Johnston, Richard F. Ambinder, Leo Luznik, Ivana Gojo, B. Douglas Douglas Smith, Ravi Varadhan, Richard J. Jones, Philip H. Imus
Publikováno v:
Blood. 140:4813-4815
Autor:
Jonathan A. Webster, Madison Reed, Hua-Ling Tsai, Alexander Ambinder, Tania Jain, Amy E. Dezern, Mark J. Levis, Margaret M. Showel, Gabrielle T. Prince, Christopher S. Hourigan, Douglas E. Gladstone, Javier Bolanos-Meade, Lukasz P. Gondek, Gabriel Ghiaur, W. Brian Dalton, Suman Paul, Ephraim J. Fuchs, Christian B. Gocke, Syed Abbas Ali, Carol Ann Huff, Ivan M. Borrello, Lode Swinnen, Nina Wagner-Johnston, Richard F. Ambinder, Leo Luznik, Ivana Gojo, B. Douglas Smith, Ravi Varadhan, Richard J. Jones, Philip H. Imus
Publikováno v:
Transplantation and cellular therapy.
Patients ≥55 years-old with acute lymphoblastic leukemia (ALL) fare poorly with conventional chemotherapy with 5-year overall survival of ∼20%. Tyrosine kinase inhibitors and novel B-cell targeted therapies improve outcomes, but rates of relapse
Autor:
Michael S. Hughes, Cole H. Sterling, Ravi Varadhan, Richard F. Ambinder, Richard J. Jones, Ronald J. Sweren, Sima Rozati, Javier Bolaños-Meade, Leo Luznik, Philip H. Imus, Syed Abbas Ali, Ivan M. Borrello, Carol Ann Huff, T. Jain, Alexander Ambinder, Amy E. DeZern, Christian B. Gocke, Douglas E. Gladstone, Lode J. Swinnen, Nina D. Wagner-Johnston, Ephraim J. Fuchs
Publikováno v:
Leukemialymphoma. 63(12)
Autor:
Francesco Mazziotta, Luca Biavati, Sonali Parbhoo, Sayan Chowdhury, Joseph Rimando, Ivan M. Borrello, Katerina Hatzi, Bruce R. Blazar, Ivana Gojo, Leo Luznik
Publikováno v:
Blood. 140:9132-9133
Autor:
Habib El-Khoury, David J Lee, Jean-Baptiste Alberge, Robert Redd, Christian J Cea-Curry, Jacqueline Perry, Hadley Barr, Ciara Murphy, Dhananjay Sakrikar, David Barnidge, Mark Bustoros, Houry Leblebjian, Anna Cowan, Maya I Davis, Julia Amstutz, Cody J Boehner, Elizabeth D Lightbody, Romanos Sklavenitis-Pistofidis, Mark C Perkins, Stephen Harding, Clifton C Mo, Prashant Kapoor, Joseph Mikhael, Ivan M Borrello, Rafael Fonseca, Scott T Weiss, Elizabeth Karlson, Lorenzo Trippa, Timothy R Rebbeck, Gad Getz, Catherine R Marinac, Irene M Ghobrial
Publikováno v:
Lancet Haematol
Prevalence estimates for monoclonal gammopathy of undetermined significance (MGUS) are based on predominantly White study populations screened by serum protein electrophoresis supplemented with immunofixation electrophoresis. A prevalence of 3% is re
Autor:
Cirino Botta, Catarina Maia, Cristina Pérez Ruiz, Irene Manrique, Juan José Garcés, Sara Rodríguez, Leire Burgos, Juana Merino, Aitziber Lopez Lopez, Noemi Puig, María Teresa Cedena, Artur Paiva, Marco Rossi, Pierosandro Tagliaferri, Piefrancesco Tassone, Massimo Gentile, Ivan M. Borrello, Laura Rosinol Dachs, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Bladé, Jesús San-Miguel, Bruno Paiva
Publikováno v:
Blood. 134:4355-4355
Background: The advent of immunotherapy renewed the interest in immune monitoring to identify determinants of treatment response. Flow cytometry is widely adopted in immunotherapy-based clinical trials, but manual analysis of multiparameter files pos