Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ivan L. Salazar"'
Autor:
Ivan L. Salazar, Ana S. T. Lourenço, Bruno Manadas, Inês Baldeiras, Cláudia Ferreira, Anabela Claro Teixeira, Vera M. Mendes, Ana Margarida Novo, Rita Machado, Sónia Batista, Maria do Carmo Macário, Mário Grãos, Lívia Sousa, Maria João Saraiva, Alberto A. C. C. Pais, Carlos B. Duarte
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-23 (2022)
Abstract Background Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflamm
Externí odkaz:
https://doaj.org/article/6b2bf2bed6834383ba5bb3e0a3f52ea9
Autor:
Wibke Singer, Marie Manthey, Rama Panford-Walsh, Lucas Matt, Hyun-Soon Geisler, Eleonora Passeri, Gabriele Baj, Enrico Tongiorgi, Graciano Leal, Carlos B. Duarte, Ivan L. Salazar, Philipp Eckert, Karin Rohbock, Jing Hu, Jörg Strotmann, Peter Ruth, Ulrike Zimmermann, Lukas Rüttiger, Thomas Ott, Thomas Schimmang, Marlies Knipper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Bdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into long-lasting network chang
Externí odkaz:
https://doaj.org/article/3cb0c2e2e5294877a4c2b7fa0e4a4b48
Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac6eeeb1540ef7f9f9e90ec08b336d3
https://hdl.handle.net/10400.14/41400
https://hdl.handle.net/10400.14/41400
Autor:
Ivan L. Salazar, Ana S. T. Lourenço, Bruno Manadas, Inês Baldeiras, Cláudia Ferreira, Anabela Claro Teixeira, Vera M. Mendes, Ana Margarida Novo, Rita Machado, Sónia Batista, Maria do Carmo Macário, Mário Grãos, Lívia Sousa, Maria João Saraiva, Alberto A. C. C. Pais, Carlos B. Duarte
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-23 (2022)
Background Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory dis
Autor:
Paulo S. Pinheiro, Ana Rita Santos, Carlos B. Duarte, Ivan L. Salazar, Marta Vieira, Miranda Mele, Pasqualino De Luca
Publikováno v:
The FASEB Journal. 35
The synaptic expression of glutamate receptors of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) type is dynamically controlled by interaction with binding partners and auxiliary proteins. These proteins can be regulated by posttran
Publikováno v:
Progress in neurobiology 143, 1-35 (2016). doi:10.1016/j.pneurobio.2016.06.001
The excessive extracellular accumulation of glutamate in the ischemic brain leads to an overactivation of glutamate receptors with consequent excitotoxic neuronal death. Neuronal demise is largely due to a sustained activation of NMDA receptors for g
Autor:
Carlos B. Duarte, Ivan L. Salazar, Carlos V. Melo, Michele Curcio, Margarida V. Caldeira, Paulo Pereira, Miranda Mele, Ana Rita Santos, Graciano Leal, Lorella M.T. Canzoniero
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1832(1):263-274
Overactivation of glutamate receptors contributes to neuronal damage (excitotoxicity) in ischemic stroke but the detailed mechanisms are not fully elucidated. Brain ischemia is also characterized by an impairment of the activity of the proteasome, on
Publikováno v:
Neurochemical research 41(1-2), 156-182 (2015). doi:10.1007/s11064-015-1752-5
Long-term synaptic plasticity in the hippocampus is thought to underlie the formation of certain forms of memory, including spatial memory. The early phase of long-term synaptic potentiation and synaptic depression depends on post-translational modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be0e14286d4a73b866a898640fa7435
Publikováno v:
Brain research. 1621
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of activity-dependent plasticity at excitatory synapses in the mammalian central nervous system. In particular, much attention has been given to the role of th
Autor:
Ivan L. Salazar, Lorella M.T. Canzoniero, Carlos B. Duarte, Margarida V. Caldeira, Michele Curcio
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The ubiquitin–proteasome system (UPS) is a catalytic machinery that targets numerous cellular proteins for degradation, thus being essential to control a wide range of basic cellular processes and cell survival. Degradation of intracellular protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c4a24f61c6aec8ede17c48f1fa0a9c