Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ivan Kopljar"'
Autor:
Ivan Kopljar, Hua Rong Lu, Karel Van Ammel, Martin Otava, Fetene Tekle, Ard Teisman, David J. Gallacher
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1365-1377 (2018)
Summary: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the ch
Externí odkaz:
https://doaj.org/article/c94301ff0e65459abf10dca1af2b44a1
Autor:
Dieter V. Van de Sande, Ivan Kopljar, Ard Teisman, David J. Gallacher, Dirk J. Snyders, Hua Rong Lu, Alain J. Labro
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The cardiac Nav1.5 mediated sodium current (INa) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluati
Externí odkaz:
https://doaj.org/article/b1a433305c5b45cfa672a0b2557ec4e8
Autor:
Alain J. Labro, Alaerts Maaike, Dieter V. Van de Sande, Dirk J. Snyders, David J. Gallacher, Luc Leybaert, Ivan Kopljar, Hua Rong Lu, Ard Teisman, Loeys Bart
Publikováno v:
CHANNELS
Channels
article-version (VoR) Version of Record
Channels
article-version (VoR) Version of Record
Human-induced pluripotent stem cell (hiPSC) and stem cell (hSC) derived cardiomyocytes (CM) are gaining popularity as in vitro model for cardiology and pharmacology studies. A remaining flaw of these cells, as shown by single-cell electrophysiologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7792880ae0346bf2a02600269cfa8243
https://biblio.ugent.be/publication/8693918/file/8693932
https://biblio.ugent.be/publication/8693918/file/8693932
Autor:
Dirk J. Snyders, David J. Gallacher, Alain J. Labro, Dieter V. Van de Sande, Ivan Kopljar, Hua Rong Lu, Ard Teisman
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
FRONTIERS IN PHARMACOLOGY
Frontiers in Pharmacology
Frontiers in pharmacology
FRONTIERS IN PHARMACOLOGY
Frontiers in Pharmacology
Frontiers in pharmacology
The cardiac Nav1.5 mediated sodium current (I-Na) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467472de975c5e752174d75e00948b90
https://doi.org/10.3389/fphar.2019.01374
https://doi.org/10.3389/fphar.2019.01374
Publikováno v:
Journal of pharmacological and toxicological methods. 104
Introduction Clinical observations are routinely used to address drug-induced behavioural changes in dogs. To deal with the limitations of this methodology, we evaluated Actiwatch-Mini® as a tool to monitor continuously locomotor activity in dogs an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51111dac77b76c553350c9a14519ef80
https://pubmed.ncbi.nlm.nih.gov/32622755
https://pubmed.ncbi.nlm.nih.gov/32622755
Autor:
Petra Vinken, David J. Gallacher, Ivan Kopljar, Nick Goeminne, Ard Teisman, Hua Rong Lu, Ilse Van den Wyngaert, An De Bondt, Bruce Damiano
Publikováno v:
British Journal of Pharmacology. 174:3766-3779
Background and Purpose In the pharmaceutical industry risk assessments of chronic cardiac safety liabilities are mostly performed during late stages of preclinical drug development using in vivo animal models. Here, we explored the potential of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bc8bbadc26e6a39cb635b59155f53b
https://doi.org/10.1111/bph.13713
https://doi.org/10.1111/bph.13713
Autor:
Jennifer B. Pierson, Armando Lagrutta, Holly Clouse, Michael Furniss, Ivan Kopljar, Frederick Sannajust, Ralf Kettenhofen, Haoyu Zeng, Hua Rong Lu, Karel Van Ammel, Fetene Tekle, Ard Teisman, Jin Zhai, Liang Guo, David J. Gallacher
Publikováno v:
Toxicol Sci
The goal of this research consortium including Janssen, MSD, Ncardia, FNCR/LBR, and Health and Environmental Sciences Institute (HESI) was to evaluate the utility of an additional in vitro assay technology to detect potential drug-induced long QT and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4418e4a66a243ef3d4307d9ae9b7ee7
https://pubmed.ncbi.nlm.nih.gov/31020317
https://pubmed.ncbi.nlm.nih.gov/31020317
Autor:
Jon D. Rainier, Dirk J. Snyders, Jan Tytgat, Evelyn Martinez-Morales, Alain J. Labro, Ivan Kopljar
Publikováno v:
Toxicon
The marine polycyclic-ether toxin gambierol and 1-butanol (n-alkanol) inhibit Shaker-type Kv channels by interfering with the gating machinery. Competition experiments indicated that both compounds do not share an overlapping binding site but gambier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9c2b59a6f66d84d6e6c7dfc729c88b
https://doi.org/10.1016/j.toxicon.2016.07.017
https://doi.org/10.1016/j.toxicon.2016.07.017
Autor:
Laure Cougnaud, Eddy Vlaminckx, An De Bondt, Hua Rong Lu, Ilse Van den Wyngaert, Ivan Kopljar, David J. Gallacher
Publikováno v:
Stem Cells Translational Medicine. 5:602-612
Histone deacetylase (HDAC) inhibitors possess therapeutic potential to reverse aberrant epigenetic changes associated with cancers, neurological diseases, and immune disorders. Unfortunately, clinical studies with some HDAC inhibitors displayed delay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76951ffefc4beb47a665d0967eaf14ec
https://doi.org/10.5966/sctm.2015-0279
https://doi.org/10.5966/sctm.2015-0279
Autor:
Hua Rong Lu, David J. Gallacher, Karel Van Ammel, Ivan Kopljar, Fetene Tekle, Ard Teisman, Martin Otava
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 11, Iss 6, Pp 1365-1377 (2018)
Stem Cell Reports, Vol 11, Iss 6, Pp 1365-1377 (2018)
Summary Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9284b8614d7717158b40733f2cc21e4
https://pubmed.ncbi.nlm.nih.gov/30540961
https://pubmed.ncbi.nlm.nih.gov/30540961