Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ivan Kompis"'
Autor:
Peter Hartman, Rudolf L. Then, Clemens Broger, Hanno Langen, Malcolm G. P. Page, R. Dehoogt, Hans Locher, Allan D'Arcy, Beat Wipf, Glenn E. Dale, Synese Jolidon, A. M. Labhardt, Christian Oefner, Dietrich Stüber, Ivan Kompis
Publikováno v:
Journal of Molecular Biology. 266:23-30
A single amino acid substitution, Phe98 to Tyr98, in dihydrofolate reductase (DHFR) is the molecular origin of trimethoprim (TMP) resistance in Staphylococcus aureus. This active site amino acid substitution was found in all S. aureus TMP-resistant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74ea0308213458adab463ca5a426ea32
https://doi.org/10.1006/jmbi.1996.0770
https://doi.org/10.1006/jmbi.1996.0770
Autor:
Christian Hubschwerlen, Malcolm G. P. Page, Valerie Runtz, Paul Hebeisen, Ingrid Heinze-Krauss, Henri Stalder, Hans Richter, Peter Angehrn, Urs Weiss, Wei Chung-Chen, Philippe Guerry, Ivan Kompis
Publikováno v:
Journal of Medicinal Chemistry. 39:1864-1871
The synthesis and structure−activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd751d7fdeabe0758dd8332f0464771
https://doi.org/10.1021/jm950886v
https://doi.org/10.1021/jm950886v
Autor:
Ivan Kompis, Vladimir I. Polshakov, Berry Birdsall, William D. Morgan, Dasa Lipovsek Sali, James Feeney
Publikováno v:
Biochemistry. 34:11690-11702
Two-dimensional (2D) double-quantum-filtered correlation spectroscopy (DQF-COSY), total correlation spectroscopy (TOCSY), nuclear Overhauser effect spectroscopy (NOESY), and rotating-frame NOESY (ROESY) spectra were used to assign essentially all the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11a9f2df22dc50fed8405eb39f62c1c
https://doi.org/10.1021/bi00037a006
https://doi.org/10.1021/bi00037a006
Publikováno v:
Helvetica Chimica Acta. 77:1057-1064
Substituted 4-oxoquinoline-3- (1a) and 4-oxo-1,8-naphthyridine-3- (1b) carboxylic acids are clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Recently, pyrimido-[1,6-a]benzimidazoles 2 were foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d076cbaeccbae58a213150d5e3081e
https://doi.org/10.1002/hlca.19940770419
https://doi.org/10.1002/hlca.19940770419
Autor:
Hans Gmuender, Peter Angehrn, Christian Hubschwerlen, Philippe Pflieger, Klaus Gubernator, Jean-Luc Specklin, Ivan Kompis
Publikováno v:
ChemInform. 24
Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede04cda0a2517a47dbe70e543745aa7
https://doi.org/10.1002/chin.199301207
https://doi.org/10.1002/chin.199301207
Publikováno v:
ChemInform. 25
Substituted 4-oxoquinoline-3- (1a) and 4-oxo-1,8-naphthyridine-3- (1b) carboxylic acids are clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Recently, pyrimido-[1,6-a]benzimidazoles 2 were foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1238848698a1df8897c45de147705cc7
https://doi.org/10.1002/chin.199448175
https://doi.org/10.1002/chin.199448175
Autor:
Christian Hubschwerlen, Henri Stalder, Urs Weiss, Philippe Guerry, Wei Chung-Chen, Hans Richter, Paul Hebeisen, Valerie Runtz, Peter Angehrn, Ivan Kompis, Malcolm G. P. Page, Ingrid Heinze-Krauss
Publikováno v:
ChemInform. 27
The synthesis and structure−activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1675404a2085604369c815a90d7adc5a
https://doi.org/10.1002/chin.199633252
https://doi.org/10.1002/chin.199633252
Autor:
Hans Gmuender, Klaus Gubernator, Jean-Luc Specklin, Peter Angehrn, Christian Hubschwerlen, Ivan Kompis, Philippe Pflieger
Publikováno v:
Journal of Medicinal Chemistry. 35:1385-1392
Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e95ac6d48406ed17f353b3f474423f
https://doi.org/10.1021/jm00086a006
https://doi.org/10.1021/jm00086a006
Publikováno v:
Helvetica Chimica Acta. 69:887-897
Based on a computer-assisted analysis of the three-dimensional structure of the binary complex of E.coli dihydrofolate reductase (DHFR) with methotrexate, 5-(N-arylnortropan-3-yl)- and 5-(N-arylpiperidin-4-yl)-2,4-diaminopyrimidines 2 and 4 were desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e998904759fe3fd80894ebf280479cfe
https://doi.org/10.1002/hlca.19860690416
https://doi.org/10.1002/hlca.19860690416
Publikováno v:
Helvetica Chimica Acta. 63:504-522
15N-NMR. spectra of mono- and diaminopyridines, and mono-, di- and triaminopyrimidines including trimethoprim and other dihydrofolate reductase inhibitors have been studied in neutral and acidic media. Complete chemical shift assignments are given. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57f09b16a490090cae102914412a994
https://doi.org/10.1002/hlca.19800630223
https://doi.org/10.1002/hlca.19800630223