Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ivan Kalina"'
Autor:
Viera Habalová, Juraj Labaj, Blanka Binkova, Zuzana Valovičová, Alena Gábelová, O. Sevastyanova, Gabriela Bačová, Radim J. Sram, Ivan Kalina, Jan Topinka, Teodor Panev, Todor A. Popov, Peter B. Farmer
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:103-113
Sensitivity and correlations among three endpoints were evaluated to assess the genotoxic potential of organic complex mixtures in vitro. This study was focused on DNA adduct formation, DNA single strand break induction and tumour suppressor p53 prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3b832bca9f791f4f4b879eef281819
https://doi.org/10.1016/j.mrfmmm.2007.02.026
https://doi.org/10.1016/j.mrfmmm.2007.02.026
Autor:
Antonina Cebulska-Wasilewska, Igor Pawłyk, A. Wiecheć, Tzveta Georgieva, Agnieszka Panek, Ivan Kalina, Peter B. Farmer, Todor A. Popov
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:145-154
The aim of this study was to investigate a possible influence of occupational exposure to carcinogenic environmental polycyclic aromatic hydrocarbons (c-PAHs) on cellular susceptibility to the induction of the DNA damage. Monitoring was performed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeb598409a03d7923561734c88361d8
https://doi.org/10.1016/j.mrfmmm.2007.03.004
https://doi.org/10.1016/j.mrfmmm.2007.03.004
Autor:
Radim J. Sram, Blanka Binkova, Peter B. Farmer, Tzveta Georgieva, Todor A. Popov, Ivan Kalina, Rajinder Singh, Seymour Garte, Emanuela Taioli
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:83-92
Polycyclic aromatic hydrocarbons (PAHs) appear to be significant contributors to the genotoxicity and carcinogenicity of air pollution present in the urban environment for humans. Populations exposed to environmental air pollution show increased leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e83d63f02b6fb1476f060e3e83c046f
https://doi.org/10.1016/j.mrfmmm.2007.02.025
https://doi.org/10.1016/j.mrfmmm.2007.02.025
Autor:
Peter B. Farmer, Blanka Binkova, Todor A. Popov, Radim J. Sram, O. Sevastyanova, Ivan Kalina, Zuzana Novakova, Jan Topinka
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:123-134
Principal aims of this study were at first, to find a relevant human derived cell line to investigate the genotoxic potential of PAH-containing complex mixtures and second, to use this cell system for the analysis of DNA adduct forming activity of or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176acaf889744a388ab59722c3d84200
https://doi.org/10.1016/j.mrfmmm.2007.03.002
https://doi.org/10.1016/j.mrfmmm.2007.03.002
Autor:
Rajinder Singh, Radim J. Sram, K. Lyubomirova, Emanuela Taioli, Blanka Binkova, Seymour Garte, Sara Raimondi, Ivan Kalina, Peter B. Farmer
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:93-102
Modification of DNA is believed to be a key step in carcinogenesis, and therefore DNA adducts have been proposed as predictive biomarkers of human cancer. Smoked and grilled foods are important contributors of PAH-DNA adduct levels, while the consump
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e495e92564d5dbaa4a94b6b12be97d3e
https://doi.org/10.1016/j.mrfmmm.2007.02.027
https://doi.org/10.1016/j.mrfmmm.2007.02.027
Autor:
Pb B. Farmer, Jana Schmuczerova, Todor A. Popov, O. Sevastyanova, Ivan Kalina, Rj J. Sram, Jan Topinka, Blanka Binkova, Zuzana Novakova
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:114-122
Acellular assay of calf thymus DNA+/-rat liver microsomal S9 fraction coupled with (32)P-postlabelling was used to study the genotoxic potential of organic compounds bound onto PM10 particles collected in three European cities-Prague (CZ), Kosice (SK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1d80c584ebc3e4e3722b9a3de7d5035
https://doi.org/10.1016/j.mrfmmm.2007.03.001
https://doi.org/10.1016/j.mrfmmm.2007.03.001
Autor:
Antonina Cebulska-Wasilewska, Peter B. Farmer, Ivan Kalina, Blanka Binkova, Radim J. Sram, Teodor Popov
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:155-164
Previous results from studies performed in three European cities suggested a decrease in DNA repair efficiency observed in lymphocytes of subjects occupationally exposed to environmental carcinogenic polycyclic aromatic hydrocarbons (c-PAHs). The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60898f6c5d263cf9b9e03627f91f973f
https://doi.org/10.1016/j.mrfmmm.2007.03.005
https://doi.org/10.1016/j.mrfmmm.2007.03.005
Autor:
Peter B. Farmer, Valentina Paracchini, Emanuela Taioli, Rajinder Singh, Todor A. Popov, Ivan Kalina, Blanka Binkova, Radim J. Sram, Seymour Garte, Sara Raimondi
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 620:7-15
Data from the EXPAH project on PAH exposure and intermediary biomarkers were analyzed with respect to individual genotypes at seven metabolic gene loci. The GSTM1 null allele was associated with significantly higher levels of two biomarkers, malondia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269a3eda6492051e42c87b75a02269d2
https://doi.org/10.1016/j.mrfmmm.2007.02.017
https://doi.org/10.1016/j.mrfmmm.2007.02.017
Autor:
Ingolf Cascorbi, Xifeng Wu, Vera Piera Leoni, Ari Hirvonen, Andre Gsur, Dorota Butkiewicz, Monica Spinola, Sisko Anttila, Sara Raimondi, Haruhiko Sugimura, Andrew C. Povey, Ivan Kalina, Magnus Ingelman-Sundberg, Marjorie Romkes, Emanuela Taioli, Alberto Ruano-Ravina, Monica Neri, Seymour Garte, Stephanie J. London, Tommaso A. Dragani, Qing Lan, Paolo Boffetta, Edyta Reszka, Gerald Haidinger, Jürgen Brockmöller, Loic Le Marchand, Angela Risch, Bernadette Schoket, Margie L. Clapper, David Ryberg, Agneta Rannug
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 592:45-57
Background Since genetic factors may play an important role in lung cancer development at low dose carcinogen exposure, non-smokers are a good model to study genetic susceptibility and its interaction with environmental factors. Materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c2d92f134d0a9e5e73162bf803b7b8
https://doi.org/10.1016/j.mrfmmm.2005.06.002
https://doi.org/10.1016/j.mrfmmm.2005.06.002
Autor:
Peter B. Farmer, Alena Gábelová, Ivan Kalina, Todor A. Popov, Antonina Cebulska-Wasilewska, Rajinder Singh, Balvinder Kaur, Emanuela Taioli, Seymour Garte, Blanka Binkova, Radim J. Sram
Publikováno v:
Mutation Research/Reviews in Mutation Research. 544:397-402
Exposure to high levels of environmental air pollution is known to be associated with an increased carcinogenic risk. The individual contribution to this risk derived from specific carcinogenic chemicals within the complex mixture of air pollution is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35303640a0d70e4ea85b8c00abf9020a
https://doi.org/10.1016/j.mrrev.2003.09.002
https://doi.org/10.1016/j.mrrev.2003.09.002