Výsledky vyhledávání - "Ivan José Magayewski Bonet"

Akademický článek

Running wheel exercise induces therapeutic and preventive effects on inflammatory stimulus-induced persistent hyperalgesia in mice.

Autor: Cesar Renato Sartori, Marco Pagliusi, Ivan José Magayewski Bonet, Claudia Herrera Tambeli, Carlos Amilcar Parada

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0240115 (2020)

Chronic pain affects significant portion of the world's population and physical exercise has been extensively indicated as non-pharmacological clinical intervention to relieve symptoms in chronic pain conditions. In general, studies on pain chronific

Externí odkaz: https://doaj.org/article/d69d849dcff8411babb4a5b4413dad0b

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Akademický článek

Physical Activity Induces Nucleus Accumbens Genes Expression Changes Preventing Chronic Pain Susceptibility Promoted by High-Fat Diet and Sedentary Behavior in Mice

Autor: Arthur Freitas Brandão, Ivan José Magayewski Bonet, Marco Pagliusi, Gabriel Gerardini Zanetti, Nam Pho, Cláudia Herrera Tambeli, Carlos Amilcar Parada, André Schwambach Vieira, Cesar Renato Sartori

Publikováno v: Frontiers in Neuroscience, Vol 13 (2020)

Recent findings from rodent studies suggest that high-fat diet (HFD) increases hyperalgesia independent of obesity status. Furthermore, weight loss interventions such as voluntary physical activity (PA) for adults with obesity or overweight was repor

Externí odkaz: https://doaj.org/article/003d83b0d4d94564a8ca5cc6cc75459f

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PI3Kγ/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization

Autor: Eugen V. Khomula, Ivan José Magayewski Bonet, Dionéia Araldi, Jon D. Levine, Paul G. Green

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 40
J Neurosci

High molecular weight hyaluronan (HMWH), a well-established treatment for osteoarthritis pain, is anti-hyperalgesic in preclinical models of inflammatory and neuropathic pain. HMWH-induced anti-hyperalgesia is mediated by its action at cluster of dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783dfe3e650f45c1dd3cf7ed2a274f87
https://doi.org/10.1523/jneurosci.1189-21.2021

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Sexually Dimorphic Role of Toll-like Receptor 4 (TLR4) in High Molecular Weight Hyaluronan (HMWH)-induced Anti-hyperalgesia

Autor: Dionéia Araldi, Ivan José Magayewski Bonet, Jon D. Levine, Paul G. Green

Publikováno v: The journal of pain, vol 22, iss 10
J Pain

High molecular weight hyaluronan (HMWH), a prominent component of the extracellular matrix binds to and signals via multiple receptors, including cluster of differentiation 44 (CD44) and toll-like receptor 4 (TLR4). We tested the hypothesis that, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db008a5df89afa6bd716bc0dc063851
https://escholarship.org/uc/item/9g989116

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Involvement of TACAN, a Mechanotransducing Ion Channel, in Inflammatory But Not Neuropathic Hyperalgesia in the Rat

Autor: Ivan José Magayewski Bonet, Oliver Bogen, Jon D. Levine, Dionéia Araldi

Publikováno v: The journal of pain, vol 22, iss 5
J Pain

TACAN (Tmem120A), a mechanotransducing ion channel highly expressed in a subset of nociceptors, has recently been shown to contribute to detection of noxious mechanical stimulation. In the present study we evaluated its role in sensitization to mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bfceea2f0669421351466800e7646a
https://escholarship.org/uc/item/4sh5w8q5

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Opioid-Induced Hyperalgesic Priming in Single Nociceptors

Autor: Ivan José Magayewski Bonet, Jon D. Levine, Dionéia Araldi, Eugen V. Khomula

Publikováno v: J Neurosci
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 1

Clinical µ-opioid receptor (MOR) agonists produce hyperalgesic priming, a form of maladaptive nociceptor neuroplasticity, resulting in pain chronification. We have established anin vitromodel of opioid-induced hyperalgesic priming (OIHP), in male ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342348347558e29d922d717bb159cbba
https://europepmc.org/articles/PMC7786210/

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Mechanisms Mediating High-Molecular-Weight Hyaluronan-Induced Antihyperalgesia

Autor: Eugen V. Khomula, Oliver Bogen, Dionéia Araldi, Ivan José Magayewski Bonet, Jon D. Levine, Paul G. Green

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 40, iss 34
J Neurosci

We evaluated the mechanism by which high-molecular-weight hyaluronan (HMWH) attenuates nociceptor sensitization, in the setting of inflammation. HMWH attenuated mechanical hyperalgesia induced by the inflammatory mediator prostaglandin E2 (PGE(2)) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431d3d63f8d22c5bb393948e6f5889fe
https://escholarship.org/uc/item/8671d3x1

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Social defeat stress-induced hyperalgesia is mediated by nav 1.8

Autor: Marco, Pagliusi, Ivan José Magayewski, Bonet, Júlia Borges Paes, Lemes, Anna Lethicia Lima, Oliveira, Nathalia Santos, Carvalho, Claudia Herrera, Tambeli, Carlos Amilcar, Parada, Cesar Renato, Sartori

Publikováno v: Neuroscience letters. 729

Recently the voltage-gated sodium (Nav) channels began to be studied as possible targets for analgesic drugs. In addition, specific Nav 1.8 blockers are currently being used to treat some types of chronic pain pathologies such as neuropathies and fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ad782530478aa9976cd1c95db8575ef
https://pubmed.ncbi.nlm.nih.gov/32387758

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