Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ivan Jelas"'
Autor:
Damian T. Rieke, Till de Bortoli, Peter Horak, Mario Lamping, Manuela Benary, Ivan Jelas, Gina Rüter, Johannes Berger, Marit Zettwitz, Niklas Kagelmann, Andreas Kind, Falk Fabian, Dieter Beule, Hanno Glimm, Benedikt Brors, Albrecht Stenzinger, Stefan Fröhling, Ulrich Keilholz
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretation of molecular data
Externí odkaz:
https://doaj.org/article/a71d027ee7a141939a13080926536b92
Autor:
Lino Möhrmann, Maximilian Werner, Małgorzata Oleś, Andreas Mock, Sebastian Uhrig, Arne Jahn, Simon Kreutzfeldt, Martina Fröhlich, Barbara Hutter, Nagarajan Paramasivam, Daniela Richter, Katja Beck, Ulrike Winter, Katrin Pfütze, Christoph E. Heilig, Veronica Teleanu, Daniel B. Lipka, Marc Zapatka, Dorothea Hanf, Catrin List, Michael Allgäuer, Roland Penzel, Gina Rüter, Ivan Jelas, Rainer Hamacher, Johanna Falkenhorst, Sebastian Wagner, Christian H. Brandts, Melanie Boerries, Anna L. Illert, Klaus H. Metzeler, C. Benedikt Westphalen, Alexander Desuki, Thomas Kindler, Gunnar Folprecht, Wilko Weichert, Benedikt Brors, Albrecht Stenzinger, Evelin Schröck, Daniel Hübschmann, Peter Horak, Christoph Heining, Stefan Fröhling, Hanno Glimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The identification of molecular biomarkers in cancer of unknown primary site (CUP) cases may enable the improvement of prognosis in these patients. Here, the authors integrate whole genome/exome, transcriptome and methylome data in 70 CUP patients, r
Externí odkaz:
https://doaj.org/article/3ed8a79da7504e68a4003ab3bffbb8af
Autor:
Laura E. Fischer, Sebastian Stintzing, Volker Heinemann, Ulrich Keilholz, Dietmar Keune, Claudia Vollbrecht, Thomas Burmeister, Andreas Kind, Lena Weiss, David Horst, Thomas Kirchner, Frederick Klauschen, Andreas Jung, Christoph Benedikt Westphalen, Ivan Jelas
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectivesThe use of liquid biopsies (LB) in patients with solid malignancies enables comprehensive genomic profiling (CGP) of circulating tumor DNA (ctDNA) and has the potential to guide therapy stratification and support disease monitoring. To exam
Externí odkaz:
https://doaj.org/article/965735d49d9549379321a45c09777ab9
Autor:
Annika Kurreck, Volker Heinemann, Ludwig Fischer von Weikersthal, Thomas Decker, Florian Kaiser, Jens Uhlig, Michael Schenk, Jens Freiberg-Richter, Bettina Peuser, Claudio Denzlinger, Ullrich Graeven, Kathrin Heinrich, Swantje Held, Arndt Stahler, Annabel Helga Sophie Alig, Ivan Jelas, Jobst C. von Einem, Sebastian Stintzing, Clemens Giessen-Jung, Dominik P. Modest
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionEarly tumor shrinkage (ETS), depth of response (DpR), and time to DpR represent exploratory endpoints that may serve as early efficacy parameters and predictors of long-term outcome in metastatic colorectal cancer (mCRC). We analyzed thes
Externí odkaz:
https://doaj.org/article/02c58eab2dbe4e41985915f0822765da
Autor:
Nadine Lackamp, Ina Wilkemeyer, Ivan Jelas, Ulrich Keller, Lars Bullinger, Sebastian Stintzing, Philipp le Coutre
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Progress in oncological treatment has led to an improved long-term survival of young male cancer patients over the last decades. However, standard cancer treatments frequently implicate fertility-damaging potential. Cryopreservation of sperm is the c
Externí odkaz:
https://doaj.org/article/83cf22e890bc4526981cd6064cef9428
Autor:
Franziska Eckert, Ivan Jelas, Moritz Oehme, Stephan M. Huber, Katja Sonntag, Christian Welker, Stephen D. Gillies, Wolfgang Strittmatter, Daniel Zips, Rupert Handgretinger, Karin Schilbach
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
NHS-IL12 is an immunocytokine, a fusion protein of IL12's functional domains and a necrosis-targeting antibody, which has shown significant effects against human rhabdomyosarcoma xenografts in a humanized tumor model, including terminal growth arrest
Externí odkaz:
https://doaj.org/article/ca5fc083737541b9952442871efd001b
Autor:
Sebastian Stintzing, Ivan Jelas
Publikováno v:
Trillium Diagnostik. 20:184-190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3e0851ec88959d745ead7424c5e0e1
https://doi.org/10.47184/td.2022.03.03
https://doi.org/10.47184/td.2022.03.03
Autor:
Markus Moehler, Laura Elisabeth Fischer, Jobst Christian von Einem, Laura Schlieker, Florian Kaiser, A. Stahler, Andreas Jung, Ivan Jelas, Dominik Paul Modest, Alexander Kiani, Ludwig Fischer von Weikersthal, Thomas Decker, Sebastian Stintzing, Kathrin Heinrich, Julian Walter Holch, Thomas Kirchner, Volker Heinemann, Christoph B. Westphalen, Annabel Helga Sophie Alig, Lena Weiss
Publikováno v:
International Journal of Cancer. 149:1935-1943
Secondary resection of metastases is recommended in metastatic colorectal cancer (mCRC). Data describing changes in mutational profiles of corresponding primary tumor and metastatic tissue after conversion treatment are limited. Next generation seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d3789afac7b092a74a3a28df8e0f3c
https://doi.org/10.1002/ijc.33747
https://doi.org/10.1002/ijc.33747
Autor:
Lino Möhrmann, Lysann Rostock, Małgorzata Oleś, Arne Jahn, Marie Arlt, Nagarajan Paramasivam, Korinna Jöhrens, Luise Rupp, Marc Schmitz, Daniela Richter, Sebastian Uhrig, Martina Fröhlich, Barbara Hutter, Jennifer Hüllein, Elena E. Wolf, Dorothea Hanf, Laura Gieldon, Simon Kreutzfeldt, Christoph E. Heilig, Veronica Teleanu, Daniel B. Lipka, Andreas Mock, Ivan Jelas, Damian T. Rieke, Marcel Wiesweg, Melanie Boerries, Anna L. Illert, Alexander Desuki, Thomas Kindler, Angela M. Krackhardt, C. Benedikt Westphalen, Heidrun Grosch, Leonidas Apostolidis, Albrecht Stenzinger, Irina A. Kerle, Christoph Heining, Daniel Hübschmann, Evelin Schröck, Stefan Fröhling, Hanno Glimm
Publikováno v:
Cancer Research. 83:926-926
Introduction: Thymic epithelial tumors (TETs) are very rare. Thymoma A and AB have a better prognosis than more aggressive thymoma B, thymic carcinoma (TC) and neuroendocrine tumors of the thymus (NET). While previous efforts such as TCGA have mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c9b0337370ed3d7fafc2c061b717de
https://doi.org/10.1158/1538-7445.am2023-926
https://doi.org/10.1158/1538-7445.am2023-926
Autor:
C. Benedikt Westphalen, Carsten Bokemeyer, Reinhard Büttner, Stefan Fröhling, Verena I. Gaidzik, Hanno Glimm, Ulrich T. Hacker, Volker Heinemann, Anna L. Illert, Ulrich Keilholz, Thomas Kindler, Martin Kirschner, Bastian Schilling, Jens T. Siveke, Thomas Schroeder, Verena Tischler, Sebastian Wagner, Wilko Weichert, Daniel Zips, Sonja Loges, Ralf Bargou (Würzburg), Hendrik Bläker (Leipzig), Melanie Börries (Freiburg), Christian Brandts (Frankfurt), Nikolas von Bubnoff (Lübeck), Melanie Demes (Frankfurt), Alexander Desuki (Mainz), Hartmut Döhner (Ulm), Justus Duyster (Freiburg), Nadine Gaisa (Aachen), Annkristin Heine (Bonn), Christoph Heining (Dresden), Peter Horak (Heidelberg), Ivan Jelas (Berlin), Philipp J. Jost (München), Andreas Jung (München), Thomas Kirchner (München), Frederick Klauschen (Berlin), Simon Kreutzfeldt (Heidelberg), Jörg Kumbrink (München), Volker Kunzmann (Würzburg), Silke Lassmann (Freiburg), Klaus Metzeler (München), Peter Möller (Ulm), Nadina Ortiz-Brüchle (Aachen), Claudia Paret (Mainz), Natalie Pelusi (Bonn), Christoph Peters (Freiburg), Nicole Pfarr (München), Daniela Richter (Dresden), Kristina Riedmann (München), Damian Rieke (Berlin), Christoph Ritzel (Mainz), Dirk Schadendorf (Essen), Hans-Ulrich Schildhaus (Essen), Hubert Schorle (Bonn), Thomas Seufferlein (Ulm), Ronald Simon (Hamburg), Albrecht Stenzinger (Heidelberg), Ghazaleh Tabatabai (Tübingen), Janna-Lisa Velthaus (Hamburg), Martin Werner (Freiburg), Peter J. Wild (Frankfurt), Jürgen Wolf (Köln)
Publikováno v:
European Journal of Cancer. 135:1-7
Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff4f13555d75c8a8b4729bce310670e
https://doi.org/10.1016/j.ejca.2020.04.019
https://doi.org/10.1016/j.ejca.2020.04.019