Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ivan J. Samardjiev"'
Autor:
Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi
Publikováno v:
Journal of Medicinal Chemistry. 60:5521-5542
Through fragment-based drug design focused on engaging the active site of IRAK4 and leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer fragment library was optimized to afford IRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d71e108dde9e50f577dacbc8e3364e
https://doi.org/10.1021/acs.jmedchem.7b00231
https://doi.org/10.1021/acs.jmedchem.7b00231
Autor:
Steve Finegan, Jennifer L. Liras, John Schafer, Gregory G. Stone, Sarah K. Wade, Ann G. Connolly, Rhonda Monahan, Katherine E. Brighty, Joan Duignan, Steven J. Brickner, Phuong Le, Ivan J. Samardjiev, Richard P. Zaniewski, Dennis Girard, Jon Bordner, Meghan Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:276-279
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31058e211b4e5cd78b92b592ecef72f
https://doi.org/10.1016/j.bmcl.2010.11.022
https://doi.org/10.1016/j.bmcl.2010.11.022
Autor:
Ashley A. Mills, Ivan J. Samardjiev, Amanda E. Riddle, David B. Damon, Brett L. Lucht, William B. Euler, Nadia Archambault, Devin Busse, Yu Wang, Allison M. Belcher
Publikováno v:
Macromolecules. 41:7115-7121
A series of regioregular poly(3-alkylthiophene)s with substituent groups R = C22H45, C24H49, C26H53, and C28H57 were synthesized. All of the materials can form a mesophase by rapid quenching from the isotropic melt. The ease of mesophase formation de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65902547512430b5f835b2937df18e85
https://doi.org/10.1021/ma801352f
https://doi.org/10.1021/ma801352f
Autor:
Makoto Kawai, Yoshinori Murata, Mio Sakai, Atsushi Omura, Kazunari Hattori, Shinichi Sakemi, Yoko Matsuoka, Ivan J. Samardjiev, Jon Bordner, Morimichi Sato, Takashi Kojima, Takashi Mano
Publikováno v:
International Journal of Pharmaceutics. 355:337-340
(−)-6-{2-[4-(3-Fluorophenyl)-4-hydroxy-piperidin-1-yl]-1-hydroxyethyl}-3,4-dihydro-quinolin-2(1H)-one (compound A) is an NR2B selective N -methyl d -aspartate (NMDA) antagonist that has shown at least two polymorphs, forms I and II. In this report,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8050a9ed33b14d0a18ce1e4c46305dd
https://doi.org/10.1016/j.ijpharm.2007.11.060
https://doi.org/10.1016/j.ijpharm.2007.11.060
Autor:
Hardwin O'dowd, Katherine E. Brighty, Michael W. Fichtner, Donn G. Wishka, Goss S. Kauffman, Mark C. Noe, Marion Bédard, Jason G. Lewis, Richard A. Buzon, Brian Samas, Jaap Kooistra, Ivan J. Samardjiev, Kathleen A. Farley, Geeta Yalamanchi
Publikováno v:
The Journal of organic chemistry. 76(6)
To facilitate a drug discovery project, we needed to develop a robust asymmetric synthesis of (2S,5S)-5-substituted-azepane-2-carboxylate derivatives. Two key requirements for the synthesis were flexibility for elaboration at C5 and suitability for l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0679bee29b243873ab7356ff8fde330
https://pubmed.ncbi.nlm.nih.gov/21275376
https://pubmed.ncbi.nlm.nih.gov/21275376
Autor:
Ivan J. Samardjiev, Brian Samas
Publikováno v:
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E, Vol 64, Iss 8, Pp o1480-o1480 (2008)
Acta Crystallographica Section E, Vol 64, Iss 8, Pp o1480-o1480 (2008)
The title compound, C12H20N+·Cl−, crystallizes with the chloride anions situated on twofold axes, while the cation is on a general position. All conventional hydrogen-bond donors and acceptors are utilized, forming a hydrogen-bonded ladder motif a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f777f4de08c5c60d117f2c5522e6eaa
https://pubmed.ncbi.nlm.nih.gov/21203192
https://pubmed.ncbi.nlm.nih.gov/21203192
Autor:
Jane M. Withka, Christopher S. Jones, Michael John Munchhof, Yuriy A. Abramov, Rescek Diane Marie, Sandra P. McCurdy, Lawrence A. Reiter, Frank M. DiCapua, Jon Bordner, William H. Brissette, Ivan J. Samardjiev
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(9)
The identification of small molecule modulators of biological processes mediated via protein–protein interactions has generally proved to be a challenging endeavor. In the case of the thrombopoietin receptor (TPOr), however, a number of small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760d0c1f270d3db21495d018daafea63
https://pubmed.ncbi.nlm.nih.gov/18396041
https://pubmed.ncbi.nlm.nih.gov/18396041
Publikováno v:
Journal of the American Chemical Society. 125(11)
A synthesis of 4,5-benzo-1-aza-tricyclo[4.3.1.1(3,8)]undecane (1), a benzo-1-aza-adamantane derivative, is described and features a previously unknown application of the Wolff-Kishner reduction of a nonresonance stabilized or "twisted" amide. An inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410928ccba13b09e98ebf8ab95625c0
https://pubmed.ncbi.nlm.nih.gov/12630882
https://pubmed.ncbi.nlm.nih.gov/12630882
Autor:
Yu Wang, Nadia Archambault, Allison M. Belcher, Devin Busse, David B. Damon, Ashley Mills, Amanda E. Riddle, Ivan J. Samardjiev, Brett L. Lucht, William B. Euler
Publikováno v:
Macromolecules; Sep2008, Vol. 41 Issue 19, p7115-7121, 7p