Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ivan Garcia-Bassets"'
Autor:
Veronika Mikhaylova, Madison Rzepka, Tetsuya Kawamura, Yu Xia, Peter L. Chang, Shiguo Zhou, Amber Paasch, Long Pham, Naisarg Modi, Likun Yao, Adrian Perez-Agustin, Sara Pagans, T. Christian Boles, Ming Lei, Yong Wang, Ivan Garcia-Bassets, Zhoutao Chen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract In the human genome, heterozygous sites refer to genomic positions with a different allele or nucleotide variant on the maternal and paternal chromosomes. Resolving these allelic differences by chromosomal copy, also known as phasing, is ach
Externí odkaz:
https://doaj.org/article/b8afd924ceaa4f0296cb028615756b0d
Autor:
Mel·lina Pinsach-Abuin, Bernat del Olmo, Adrian Pérez-Agustin, Jesus Mates, Catarina Allegue, Anna Iglesias, Qi Ma, Daria Merkurjev, Sergiy Konovalov, Jing Zhang, Farah Sheikh, Amalio Telenti, Josep Brugada, Ramon Brugada, Melissa Gymrek, Julia di Iulio, Ivan Garcia-Bassets, Sara Pagans
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100250- (2021)
Summary: Genome-wide association studies (GWASs) are instrumental in identifying loci harboring common single-nucleotide variants (SNVs) that affect human traits and diseases. GWAS hits emerge in clusters, but the focus is often on the most significa
Externí odkaz:
https://doaj.org/article/6c838ad5069a44029f4b3ea3f35643c1
Autor:
Qi Ma, Feng Yang, Carlos Mackintosh, Ranveer Singh Jayani, Soohwan Oh, Chunyu Jin, Sreejith Janardhanan Nair, Daria Merkurjev, Wubin Ma, Stephanie Allen, Dong Wang, Angels Almenar-Queralt, Ivan Garcia-Bassets
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Cisplatin is an antineoplastic drug administered at suboptimal and intermittent doses to avoid life-threatening effects. Although this regimen shortly improves symptoms in the short term, it also leads to more malignant disease in the long t
Externí odkaz:
https://doaj.org/article/50ac903137cb4210b15ac40955ec50f1
Autor:
Christopher Benner, Sergiy Konovalov, Carlos Mackintosh, Kasey R Hutt, Rieka Stunnenberg, Ivan Garcia-Bassets
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003906 (2013)
Genome-wide maps of DNase I hypersensitive sites (DHSs) reveal that most human promoters contain perpetually active cis-regulatory elements between -150 bp and +50 bp (-150/+50 bp) relative to the transcription start site (TSS). Transcription factors
Externí odkaz:
https://doaj.org/article/411a363af1d0450db1c55ef09c6f6edd
Autor:
Laure Escoubet-Lozach, Christopher Benner, Minna U Kaikkonen, Jean Lozach, Sven Heinz, Nathan J Spann, Andrea Crotti, Josh Stender, Serena Ghisletti, Donna Reichart, Christine S Cheng, Rosa Luna, Colleen Ludka, Roman Sasik, Ivan Garcia-Bassets, Alexander Hoffmann, Shankar Subramaniam, Gary Hardiman, Michael G Rosenfeld, Christopher K Glass
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002401 (2011)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biologica
Externí odkaz:
https://doaj.org/article/f69a8d7af71742de8be55e14a6e909d9
Autor:
Veronika Mikhaylova, Madison Rzepka, Tetsuya Kawamura, Yu Xia, Peter L. Chang, Shiguo Zhou, Long Pham, Naisarg Modi, Likun Yao, Adrian Perez-Agustin, Sara Pagans, T. Christian Boles, Ming Lei, Yong Wang, Ivan Garcia-Bassets, Zhoutao Chen
In the human genome, heterozygous sites are genomic positions with different alleles inherited from each parent. On average, there is a heterozygous site every 1-2 kilobases (kb). Resolving whether two alleles in neighboring heterozygous positions ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed28ac5173e4b02be474ca366de09aa
https://doi.org/10.1101/2023.03.05.531179
https://doi.org/10.1101/2023.03.05.531179
Autor:
Kenneth A. Ohgi, Feng Xiong, Xiaoyu Zhu, Jiaofang Shao, Michael G. Rosenfeld, Feng Yang, Ruoyu Wang, Matteo D’Antonio, Wenbo Li, Kelly A. Frazer, Sreejith J Nair, Joo-Hyung Lee, Qi Ma, Joydeep Mitra, Soohwan Oh, Ivan Garcia-Bassets, Zhengdong D. Zhang
Publikováno v:
Nature. 595:735-740
The functional engagement between an enhancer and its target promoter ensures precise gene transcription1. Understanding the basis of promoter choice by enhancers has important implications for health and disease. Here we report that functional loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f316bcadab6fb44e50801738222d86c0
https://doi.org/10.1038/s41586-021-03577-1
https://doi.org/10.1038/s41586-021-03577-1
Autor:
Wei Guo, Yanmei Zhang, Ivan Garcia-Bassets, Zai Chang, Kequan Lin, Shuaishuai Teng, Pengyuan Wang, Zhi John Lu, Rui Qi, Ming Yang, Qunsheng Ji, Yiming Huang, Shasha Li, Yujing Cheng, Yang Eric Li, Dong Wang, Yang Cao, Qingyang Gu, Qianyu Wang, Shanwen Chen
Publikováno v:
Cell Res
Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to and colonize new tissue environments. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994dbb63238c10fd967a185377867370
https://doi.org/10.1038/s41422-019-0259-z
https://doi.org/10.1038/s41422-019-0259-z
Autor:
Ivan Garcia-Bassets, Angels Almenar-Queralt, Likun Yao, Bernat del Olmo, Daria Merkurjev, Mel·lina Pinsach-Abuin
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621189
Human induced pluripotent and embryonic stem cell cultures (hiPSC/hESC) are phenotypically heterogeneous and prone to clonal deviations during subculturing and differentiation. Clonal deviations often emerge unnoticed, but they can change the biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d3c9ede521632813245b1c1e20b318
https://doi.org/10.1007/7651_2021_414
https://doi.org/10.1007/7651_2021_414
Autor:
Bakker C, Rajesh Ambasudhan, Melissa Luevanos, Pawel Stankiewicz, Abdullah Sultan, Daniel H. Geschwind, Nima Dolatabadi, Riki Kawaguchi, Nicholas J. Schork, Maria Talantova, Michael G. Rosenfeld, Yongwook Choi, Teranaka M, Ivan Garcia-Bassets, Agnes P. Chan, Grabauskas T, James C. Parker, Kozbial P, Swagata Ghatak, Stuart A. Lipton, Shing Fai Chan, Kevin M. Lopez, Nobuki Nakanishi, Noveral Sm, Dorit Trudler
MEF2C has been shown to be a critical transcription factor for neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d399ffbf3ff7ea7c0988109d1c98e31c
https://doi.org/10.1101/2020.11.19.387639
https://doi.org/10.1101/2020.11.19.387639