Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ivan Gallotta"'
Autor:
Maria Laura Di Giorgio, Alessandro Esposito, Paolo Maccallini, Emanuela Micheli, Francesca Bavasso, Ivan Gallotta, Fiammetta Vernì, Fabian Feiguin, Stefano Cacchione, Brian D. McCabe, Elia Di Schiavi, Grazia Daniela Raffa
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 42-50 (2017)
SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism,
Externí odkaz:
https://doaj.org/article/209d89e69a52400db676182d017518fb
Autor:
Ambra Lanzo, Bryan D. Safratowich, Sirisha R. Kudumala, Ivan Gallotta, Giuseppina Zampi, Elia Di Schiavi, Lucia Carvelli
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The dopamine transporter (DAT) is a cell membrane protein whose main function is to reuptake the dopamine (DA) released in the synaptic cleft back into the dopaminergic neurons. Previous studies suggested that the activity of DAT is regulated by allo
Externí odkaz:
https://doaj.org/article/ad055b7fe75d4751abde8ddc5b61db55
Autor:
Lu Chen, Caitlin M Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, Pamela Santonicola, Natalia Mendoza-Ferreira, Livia Scatolini, Ludovico Rizzuti, Alessandro Esposito, Ivan Gallotta, Sofia Francia, Stefano Cacchione, Alessandra Galati, Valeria Palumbo, Marie A Kobin, Gian Gaetano Tartaglia, Alessio Colantoni, Gabriele Proietti, Yunming Wu, Matthias Hammerschmidt, Cristiano De Pittà, Gabriele Sales, Julia Salzman, Livio Pellizzoni, Brunhilde Wirth, Elia Di Schiavi, Maurizio Gatti, Steven E Artandi, Grazia D Raffa
Publikováno v:
Nucleic Acids Research. 50:12400-12424
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5′-monomethylguanosine cap of small nuclear RNAs (snRNAs) to a trimethylguanosine cap. Here, we show that loss of TGS1 in Caenorhabditis elegans, Drosophila melanog
Autor:
Lu Chen, Caitlin M. Roake, Paolo Maccallini, Francesca Bavasso, Roozbeh Dehghannasiri, Pamela Santonicola, Natalia Mendoza-Ferreira, Livia Scatolini, Ludovico Rizzuti, Alessandro Esposito, Ivan Gallotta, Sofia Francia, Stefano Cacchione, Alessandra Galati, Valeria Palumbo, Gian Gaetano Tartaglia, Alessio Colantoni, Gabriele Proietti, Yunming Wu, Matthias Hammerschmidt, Cristiano De Pittà, Gabriele Sales, Julia Salzman, Livio Pellizzoni, Brunhilde Wirth, Elia Di Schiavi, Maurizio Gatti, Steven E. Artandi, Grazia D. Raffa
Publikováno v:
bioRxiv the preprint server for biology (2020). doi:10.1101/2020.10.27.356782
info:cnr-pdr/source/autori:Lu Chen123*, Caitlin M. Roake123*, Paolo Maccallini4, Francesca Bavasso4, Roozbeh Dehghannasiri3, Pamela Santonicola5, Natalia Mendoza-Ferreira6, Livia Scatolini4, Ludovico Rizzuti4, Alessandro Esposito7, Ivan Gallotta7, Sofia Francia89, Stefano Cacchione4, Matthias Hammerschmidt10, Cristiano De Pittà11, Gabriele Sales11, Julia Salzman13, Livio Pellizzoni121314, Brunhilde Wirth615, Elia Di Schiavi57, Maurizio Gatti416, Steven E. Artandi123# and Grazia D. Raffa417#/titolo:TGS1 controls snRNA 3' end processing, prevents neurodegeneration and amelioratesSMN-dependent neurological phenotypes in vivo/doi:10.1101%2F2020.10.27.356782/rivista:bioRxiv the preprint server for biology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Lu Chen123*, Caitlin M. Roake123*, Paolo Maccallini4, Francesca Bavasso4, Roozbeh Dehghannasiri3, Pamela Santonicola5, Natalia Mendoza-Ferreira6, Livia Scatolini4, Ludovico Rizzuti4, Alessandro Esposito7, Ivan Gallotta7, Sofia Francia89, Stefano Cacchione4, Matthias Hammerschmidt10, Cristiano De Pittà11, Gabriele Sales11, Julia Salzman13, Livio Pellizzoni121314, Brunhilde Wirth615, Elia Di Schiavi57, Maurizio Gatti416, Steven E. Artandi123# and Grazia D. Raffa417#/titolo:TGS1 controls snRNA 3' end processing, prevents neurodegeneration and amelioratesSMN-dependent neurological phenotypes in vivo/doi:10.1101%2F2020.10.27.356782/rivista:bioRxiv the preprint server for biology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5’ mono-methylguanosine cap of snRNAs to a trimethylguanosine cap. Here, we show that loss of TGS1 in C. elegans, D. melanogaster and D. rerio results in neurologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f54fc9aa1ec0818fd097fcf7d36a9bf
Autor:
Raimund Jung, Waltraud Röseler, Sinem Agilkaya, Ivan Gallotta, Martin Haslbeck, Ralf J. Sommer, Della C. David, Christian Rödelsperger, Chaolie Huang, Jane L. Blersch, Aneet Sandhu, Maximilian Peters
Publikováno v:
Nature / Physical science 584(7821), 410-414 (2020). doi:10.1038/s41586-020-2461-z
In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells. Compared with the relatively constant intracellular environment, conditions for proteins in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551d1df24598615d1d5f8f956f7e582
Autor:
Ivan Gallotta, Ivan de Carlos Cáceres, Elia Di Schiavi, Hang Lu, Daniel A. Porto, Pamela Santonicola, Josue Rodríguez-Cordero
Publikováno v:
Integrative biology (Camb., Print) 10 (2018): 539–548. doi:10.1039/c8ib00091c
info:cnr-pdr/source/autori:Caceres, Ivan de Carlos; Porto, Daniel A.; Gallotta, Ivan; Santonicola, Pamela; Rodriguez-Cordero, Josue; Di Schiavi, Elia; Lu, Hang/titolo:Automated screening of C. elegans neurodegeneration mutants enabled by microfluidics and image analysis algorithms/doi:10.1039%2Fc8ib00091c/rivista:Integrative biology (Camb., Print)/anno:2018/pagina_da:539/pagina_a:548/intervallo_pagine:539–548/volume:10
info:cnr-pdr/source/autori:Caceres, Ivan de Carlos; Porto, Daniel A.; Gallotta, Ivan; Santonicola, Pamela; Rodriguez-Cordero, Josue; Di Schiavi, Elia; Lu, Hang/titolo:Automated screening of C. elegans neurodegeneration mutants enabled by microfluidics and image analysis algorithms/doi:10.1039%2Fc8ib00091c/rivista:Integrative biology (Camb., Print)/anno:2018/pagina_da:539/pagina_a:548/intervallo_pagine:539–548/volume:10
Spinal muscular atrophy (SMA) is a degenerative disorder that selectively deteriorates motor neurons due to a deficiency of survival motor neuron protein (SMN). The illness is the leading genetic cause of death in infants and is difficult to study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d60f599ee4746ea62bd3be3190d9686
http://www.cnr.it/prodotto/i/392041
http://www.cnr.it/prodotto/i/392041
Publikováno v:
Journal of Visualized Experiments.
In the last decades, the prevalence of neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD), has grown. These age-associated disorders are characterized by the appearance of protein aggregates with fibrillary str
Autor:
Nicole, Groh, Ivan, Gallotta, Marie C, Lechler, Chaolie, Huang, Raimund, Jung, Della C, David
Publikováno v:
JoVE journal Biology(129), 56464 (2017). doi:10.3791/56464
In the last decades, the prevalence of neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD), has grown. These age-associated disorders are characterized by the appearance of protein aggregates with fibrillary str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f9331a1fe485b30cbb1aa6fa5233d53
Autor:
Grazia D. Raffa, Paolo Maccallini, Alessandro Esposito, Ivan Gallotta, Maria Laura Di Giorgio, Brian D. McCabe, Stefano Cacchione, Fiammetta Vernì, Francesca Bavasso, Fabian Feiguin, Elia Di Schiavi, Emanuela Micheli
Publikováno v:
Neurobiology of disease 105 (2017): 42–50. doi:10.1016/j.nbd.2017.05.005
info:cnr-pdr/source/autori:Di Giorgio, Maria Laura; Esposito, Alessandro; Maccallini, Paolo; Micheli, Emanuela; Bavasso, Francesca; Gallotta, Ivan; Verni, Fiammetta; Feiguin, Fabian; Cacchione, Stefano; McCabe, Brian D.; Di Schiavi, Elia; Raffa, Grazia Daniela/titolo:WDR79%2FTCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models/doi:10.1016%2Fj.nbd.2017.05.005/rivista:Neurobiology of disease/anno:2017/pagina_da:42/pagina_a:50/intervallo_pagine:42–50/volume:105
Neurobiology of Disease, Vol 105, Iss, Pp 42-50 (2017)
info:cnr-pdr/source/autori:Di Giorgio, Maria Laura; Esposito, Alessandro; Maccallini, Paolo; Micheli, Emanuela; Bavasso, Francesca; Gallotta, Ivan; Verni, Fiammetta; Feiguin, Fabian; Cacchione, Stefano; McCabe, Brian D.; Di Schiavi, Elia; Raffa, Grazia Daniela/titolo:WDR79%2FTCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models/doi:10.1016%2Fj.nbd.2017.05.005/rivista:Neurobiology of disease/anno:2017/pagina_da:42/pagina_a:50/intervallo_pagine:42–50/volume:105
Neurobiology of Disease, Vol 105, Iss, Pp 42-50 (2017)
SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c147c5c4ac8964bc1ea39f68a95e2ec
http://hdl.handle.net/11573/955559
http://hdl.handle.net/11573/955559
Autor:
Ivan Gallotta 1, 2, Nadia Mazzarella 1, Alessandra Donato 1, 3 Alessandro Esposito 1, Justin C. Chaplin 3, Silvana Castro 1, Giuseppina Zampi 1, Giorgio S. Battaglia 4, Massimo A. Hilliard 3, Paolo Bazzicalupo 1, Elia Di Schiavi 1
Publikováno v:
Human molecular genetics
(2016): 1–14. doi:10.1093/hmg/ddw119
info:cnr-pdr/source/autori:Ivan Gallotta 1,2, Nadia Mazzarella 1,2, Alessandra Donato 1,3 Alessandro Esposito 1, Justin C. Chaplin 3, Silvana Castro 1, Giuseppina Zampi 1,2, Giorgio S. Battaglia 4, Massimo A. Hilliard 3, Paolo Bazzicalupo 1,2 and Elia Di Schiavi 1,2/titolo:Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism/doi:10.1093%2Fhmg%2Fddw119/rivista:Human molecular genetics (Print)/anno:2016/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume
Human Molecular Genetics
(2016): 1–14. doi:10.1093/hmg/ddw119
info:cnr-pdr/source/autori:Ivan Gallotta 1,2, Nadia Mazzarella 1,2, Alessandra Donato 1,3 Alessandro Esposito 1, Justin C. Chaplin 3, Silvana Castro 1, Giuseppina Zampi 1,2, Giorgio S. Battaglia 4, Massimo A. Hilliard 3, Paolo Bazzicalupo 1,2 and Elia Di Schiavi 1,2/titolo:Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism/doi:10.1093%2Fhmg%2Fddw119/rivista:Human molecular genetics (Print)/anno:2016/pagina_da:1/pagina_a:14/intervallo_pagine:1–14/volume
Human Molecular Genetics
Spinal muscular atrophy is a devastating disease that is characterized by degeneration and death of a specific subclass of motor neurons in the anterior horn of the spinal cord. Although the gene responsible, survival motor neuron 1 (SMN1), was ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dcc11bb40fe32c18e401bac95f90fb