Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ivan Dotu"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Many epidemiological models and algorithms are used to fit the parameters of a given epidemic curve. On many occasions, fitting algorithms are interleaved with the actual epidemic models, which yields combinations of model-parameters that ar
Externí odkaz:
https://doaj.org/article/1b06186294c54861a0ea1393c2b45109
Autor:
Clara Suñer, Annarita Sibilio, Judit Martín, Chiara Lara Castellazzi, Oscar Reina, Ivan Dotu, Adrià Caballé, Elisa Rivas, Vittorio Calderone, Juana Díez, Angel R Nebreda, Raúl Méndez
Publikováno v:
eLife, Vol 11 (2022)
Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenyla
Externí odkaz:
https://doaj.org/article/4e3e383266cb49608da7a9a2ea87fedf
Autor:
Ivan Dotu, Scott I Adamson, Benjamin Coleman, Cyril Fournier, Emma Ricart-Altimiras, Eduardo Eyras, Jeffrey H Chuang
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006078 (2018)
RNA-protein binding is critical to gene regulation, controlling fundamental processes including splicing, translation, localization and stability, and aberrant RNA-protein interactions are known to play a role in a wide variety of diseases. However,
Externí odkaz:
https://doaj.org/article/9acce46fc8724d6abe84f928cd8dadf6
Publikováno v:
eLife, Vol 5 (2016)
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of C57BL/6J-Gtpbp2nmf205-/-
Externí odkaz:
https://doaj.org/article/4e33e8f16d1c4cf9ad15a0bfcbf9450b
Autor:
Rodrigo Cilla, Vinodh Mechery, Beatriz Hernandez de Madrid, Steven Del Signore, Ivan Dotu, Victor Hatini
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004124 (2015)
Epithelial morphogenesis generates the shape of tissues, organs and embryos and is fundamental for their proper function. It is a dynamic process that occurs at multiple spatial scales from macromolecular dynamics, to cell deformations, mitosis and a
Externí odkaz:
https://doaj.org/article/efc500b9bc594c86ba389a6e2e0eff1a
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e85412 (2014)
We describe the first algorithm and software, RNAenn, to compute the partition function and minimum free energy secondary structure for RNA with respect to an extended nearest neighbor energy model. Our next-nearest-neighbor triplet energy model appe
Externí odkaz:
https://doaj.org/article/a773dfda157c4725b7d792cdbe364035
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50506 (2012)
Using complex roots of unity and the Fast Fourier Transform, we design a new thermodynamics-based algorithm, FFTbor, that computes the Boltzmann probability that secondary structures differ by [Formula: see text] base pairs from an arbitrary initial
Externí odkaz:
https://doaj.org/article/2e7cf30e770a41ba88b630c8ce791991
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45160 (2012)
Chemical and enzymatic footprinting experiments, such as shape (selective 2'-hydroxyl acylation analyzed by primer extension), yield important information about RNA secondary structure. Indeed, since the [Formula: see text]-hydroxyl is reactive at fl
Externí odkaz:
https://doaj.org/article/185a8d187a5b40b4b891a6275f5840ac
Publikováno v:
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
© The Author(s) 2021.
Novel tools for in silico design of RNA constructs such as riboregulators are required in order to reduce time and cost to production for the development of diagnostic and therapeutic advances. Here, we present MoiRNAiFold
Novel tools for in silico design of RNA constructs such as riboregulators are required in order to reduce time and cost to production for the development of diagnostic and therapeutic advances. Here, we present MoiRNAiFold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c858019f599cd7d5ca41333df5a0311
https://doi.org/10.1093/nar/gkab331
https://doi.org/10.1093/nar/gkab331
Autor:
Annarita Sibilio, Clara Suñer, Judit Martín, Chiara Lara Castellazzi, Oscar Reina, Ivan Dotu, Adrià Caballé, Elisa Rivas, Vittorio Calderone, Juana Díez, Angel R Nebreda, Raúl Méndez
Publikováno v:
eLife. 11
Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ded65aaa22929527965b24443335d0
https://doi.org/10.7554/elife.75873
https://doi.org/10.7554/elife.75873