Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ivan Diakonov"'
Autor:
Aleksandra Judina, Marili Niglas, Vladislav Leonov, Nicholas S. Kirkby, Ivan Diakonov, Peter T. Wright, Lan Zhao, Jane A. Mitchell, Julia Gorelik
Publikováno v:
Cells, Vol 12, Iss 23, p 2764 (2023)
(1) Pulmonary hypertension (PH)-associated right ventricular (RV) failure is linked to a reduction in pulmonary vasodilators. Treprostinil has shown effectiveness in PAH patients with cardiac decompensation, hinting at potential cardiac benefits. We
Externí odkaz:
https://doaj.org/article/d9c9e0ef31eb4ac383dcf8f7feb383b1
Autor:
Maria Faleeva, Ivan Diakonov, Prashant Srivastava, Masoud Ramuz, Gaia Calamera, Kjetil Wessel Andressen, Nadja Bork, Lorenza Tsansizi, Marie-Victoire Cosson, Andreia Sofia Bernardo, Viacheslav Nikolaev, Julia Gorelik
Publikováno v:
Cells, Vol 11, Iss 20, p 3257 (2022)
The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established. However, the development and signal compartmentation of this crucial pathway h
Externí odkaz:
https://doaj.org/article/da1e9dac2d0d4e5ab9795c3a573d9544
Autor:
Effendi Ibrahim, Ivan Diakonov, Dulasi Arunthavarajah, Teresa Swift, Mary Goodwin, Saraid McIlvride, Vanya Nikolova, Catherine Williamson, Julia Gorelik
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Bile acids are recognised as bioactive signalling molecules. While they are known to influence arrhythmia susceptibility in cholestasis, there is limited knowledge about the underlying mechanisms. To delineate mechanisms underlying fetal hea
Externí odkaz:
https://doaj.org/article/b9f80aa5866a41af9eb558fcc06bf458
Autor:
Peter T. Wright, Navneet K. Bhogal, Ivan Diakonov, Laura M.K. Pannell, Ruwan K. Perera, Nadja I. Bork, Sophie Schobesberger, Carla Lucarelli, Giuseppe Faggian, Anita Alvarez-Laviada, Manuela Zaccolo, Timothy J. Kamp, Ravi C. Balijepalli, Alexander R. Lyon, Sian E. Harding, Viacheslav O. Nikolaev, Julia Gorelik
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 459-469 (2018)
Summary: Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β2-adrenoceptor (β2AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce com
Externí odkaz:
https://doaj.org/article/9fb32f6b27744542b14dddf7b8ced575
Autor:
Michele Miragoli, Jose L. Sanchez-Alonso, Anamika Bhargava, Peter T. Wright, Markus Sikkel, Sophie Schobesberger, Ivan Diakonov, Pavel Novak, Alessandra Castaldi, Paola Cattaneo, Alexander R. Lyon, Max J. Lab, Julia Gorelik
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 140-151 (2016)
Arrhythmogenesis during heart failure is a major clinical problem. Regional electrical gradients produce arrhythmias, and cellular ionic transmembrane gradients are its originators. We investigated whether the nanoscale mechanosensitive properties of
Externí odkaz:
https://doaj.org/article/1d635e6cbdab41fab11e7f366de7d465
Autor:
Alveera Hasan, Neda Mohammadi, Aisha Nawaz, Thusharika Kodagoda, Ivan Diakonov, Sian E. Harding, Julia Gorelik
Publikováno v:
Cells, Vol 9, Iss 10, p 2275 (2020)
The ability to differentiate induced-pluripotent stem cells into cardiomyocytes (iPSC-CMs) has opened up novel avenues for potential cardiac therapies. However, iPSC-CMs exhibit a range of somewhat immature functional properties. This study explored
Externí odkaz:
https://doaj.org/article/7fc30d1972af4a7c833c477a333b894f
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2483
The newly generated software plugin MultiFRET allows for real-time measurements of multiplexed fluorescent biosensors in a near high-throughput fashion. Here we describe a detailed protocol for setup and use of this software for any purpose requiring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9cb82c6786742b4854815595042eb85
https://pubmed.ncbi.nlm.nih.gov/35286668
https://pubmed.ncbi.nlm.nih.gov/35286668
Publikováno v:
cAMP Signaling ISBN: 9781071622445
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::474f68b88d02cebdecbaf12e22ef007c
https://doi.org/10.1007/978-1-0716-2245-2_3
https://doi.org/10.1007/978-1-0716-2245-2_3
Publikováno v:
E3S Web of Conferences. 371:02002
The article considers the issues of geotechnical substantiation and application of constructive and technological measures for the construction of underground space up to 4.4 m deep in the closed courtyard of the Palace built in the 18th century in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e1c5baeef2c32a0a8ae98771b5de4a
https://doi.org/10.1051/e3sconf/202337102002
https://doi.org/10.1051/e3sconf/202337102002
Publikováno v:
E3S Web of Conferences. 371:02012
The article discusses the features of monitoring the dynamic impact, processes of vibration driving and vibro-extraction of sheet piles in conditions of a large thickness of weak, water-saturated soils. Many years of development experience has shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e255ab43078ff47cbab2788185af50a9
https://doi.org/10.1051/e3sconf/202337102012
https://doi.org/10.1051/e3sconf/202337102012