Reliability of Cell-Free DNA and Targeted NGS in Predicting Chromosomal Abnormalities of Patients With Myeloid Neoplasms

Autor: Andrew Ip, Alexandra Della Pia, Gee Youn (Geeny) Kim, Jason Lofters, James Behrmann, Dylon Patel, Simone Kats, Jeffrey Justin Estella, Ivan De Dios, Wanlong Ma, Andrew L. Pecora, Andre H. Goy, Jamie Koprivnikar, James K. McCloskey, Maher Albitar

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

IntroductionCytogenetic analysis is important for stratifying patients with various neoplasms. We explored the use of targeted next generation sequencing (NGS) in detecting chromosomal structural abnormalities or copy number variations (CNVs) in pati

Externí odkaz: https://doaj.org/article/841f74756f494596ab6c774a50e1ff13

Accuracy of predicting IgHV mutation status in chronic lymphocytic leukemia using RNA expression profiling and machine learning

Autor: Ahmad Charifa, Hong Zhang, Andrew Pecora, Andrew Ip, Ivan De Dios, Wanlong Ma, Lori A. Leslie, Tatyana Feldman, Andre Goy, Maher Albitar

Publikováno v: Journal of Medical Artificial Intelligence. 5:10-10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d4eb3deb11a0999f9b0f68b8767c70d
https://doi.org/10.21037/jmai-22-28

Combining cell-free RNA (cfRNA) with cell-free total nucleic acid (cfTNA) as a new paradigm for liquid biopsy

Autor: Maher Albitar, Hong Zhang, Ahmad Charifa, Andrew Ip, Ivan De Dios, Wanlong Ma, James K. McCloskey, Michele Donato, David Samuel DiCapua Siegel, Stanley E. Waintraub, Martin Gutierrez, Andrew L Pecora, Andre Goy

Publikováno v: Journal of Clinical Oncology. 40:3048-3048

3048 Background: Expressed RNA can capture mutations, gene fusions, and biomarker profiles. In principle, each abnormal cell has one copy of mutated gene, but numerous copies of mutated RNA. Cell-free RNA (cfRNA) is not used due to the assumption tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2ccc7de9d1b476c34816fd2974ffc95
https://doi.org/10.1200/jco.2022.40.16_suppl.3048

A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL

Autor: Alexandar Tzankov, Maurilio Ponzoni, Wayne Tam, Miguel A. Piris, Ken H. Young, Feng Zhu, Babak Shahbaba, Carlo Visco, Michael Boe Møller, Bing Xu, April Chiu, Hongwei Zhang, Eric D. Hsi, Karen Dybkær, Yong Li, Benjamin M. Parsons, Hong Zhang, Govind Bhagat, Ivan De Dios, Zijun Y. Xu-Monette, Youli Zu, Jooryung Huh, Hua You, Maher Albitar, Fredrick B. Hagemeister, Jane N. Winter, J. Han van Krieken, Andrés J.M. Ferreri

Publikováno v: Blood Advances, 4, 28-3404
Blood Adv
Xu-Monette, Z Y, Zhang, H, Zhu, F, Tzankov, A, Bhagat, G, Visco, C, Dybkaer, K, Chiu, A, Tam, W, Zu, Y, Hsi, E D, You, H, Huh, J, Ponzoni, M, Ferreri, A J M, Møller, M B, Parsons, B M, van Krieken, J H, Piris, M A, Winter, J N, Hagemeister, F B, Shahbaba, B, De Dios, I, Zhang, H, Li, Y, Xu, B, Albitar, M & Young, K H 2020, ' A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL ', Blood advances, vol. 4, no. 14, pp. 3391-3404 . https://doi.org/10.1182/bloodadvances.2020001949
Blood advances, vol 4, iss 14
Xu-Monette, Z Y, Zhang, H, Zhu, F, Tzankov, A, Bhagat, G, Visco, C, Dybkaer, K, Chiu, A, Tam, W, Zu, Y, Hsi, E D, You, H, Huh, J, Ponzoni, M, Ferreri, A J M, Møller, M B, Parsons, B M, Han van Krieken, J, Piris, M A, Winter, J N, Hagemeister, F B, Shahbaba, B, de Dios, I, Zhang, H, Li, Y, Xu, B, Albitar, M & Young, K H 2020, ' A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL ', Blood advances, vol. 4, no. 14, pp. 3391-3404 . https://doi.org/10.1182/bloodadvances.2020001949
Blood Advances, 4, 14, pp. 28-3404

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity of B-cell lymphoma. Cell-of-origin (COO) classification of DLBCL is required in routine practice by the World Health Organization classification for biological and therapeutic insights.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cab6f4fba3f040d2a18798264b72db
http://hdl.handle.net/2066/222478

Bone Marrow-Based Biomarkers for Predicting aGVHD Using Targeted RNA Next Generation Sequencing and Machine Learning

Autor: Andrew Ip, Andre Goy, Scott D. Rowley, Hong Zhang, Andrew L. Pecora, Ivan De Dios, Hyung C. Suh, Sukhdeep Kaur, Michele L. Donato, Wanlong Ma, Maher Albitar, Spiraggelos Antzoulatos

Publikováno v: Blood. 138:2892-2892

Introduction: Acute graft-vs.-host disease (aGVHD) remains a major diagnostic and clinical problem in patients after allogenic hematopoietic stem cell transplant (HSCT). Finding biomarkers that play a role in aGVHD not only helps in predicting and di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::388a03142f9211e93338c0b15f027874
https://doi.org/10.1182/blood-2021-147583