Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ivan D. Mascanfroni"'
Autor:
William M. Siders, Qingping Wang, Rui Kuai, Jonathan Rothblatt, Francisco J. Quintana, Juliet Musabeyezu, Yuka Milton, Heidi Kuang, Manal Alaamery, Ivan D. Mascanfroni, Martina Heinelt, Veit Rothhammer, Ali H. Alhasan, Haoyue Lan, Jessica E. Kenison, Marie-Christine Multon, Jeffrey M. Karp, Helia Safaee, Christelle Perrault, Oren Levy, Michael De Biasio, Tahir Majid, Salam Massadeh, Ada Yeste, Zhixiang Tong
Publikováno v:
J Mol Med (Berl)
Mesenchymal stem cells (MSCs) are promising candidates for the development of cell-based drug delivery systems for autoimmune inflammatory diseases, such as multiple sclerosis (MS). Here, we investigated the effect of Ro-31-8425, an ATP-competitive k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652ad45816e0721a288e4e55fa707693
https://pubmed.ncbi.nlm.nih.gov/33398468
https://pubmed.ncbi.nlm.nih.gov/33398468
Autor:
Mauricio F. Farez, Hailei Zhang, Michael A. Wheeler, Stephanie Zandee, Kalil Alves de Lima, Howard L. Weiner, Gad Getz, Jack P. Antel, Jessica E. Kenison, Ivan D. Mascanfroni, Chun-Cheih Chao, Luke M. Healy, Maisa C. Takenaka, Sonja Rothweiler, Veit Rothhammer, David A. Reardon, Andreia Barroso, Emily C. Tjon, David H. Sherr, Galina Gabriely, Tyler Vandeventer, Francisco J. Quintana, Alexandre Prat, Cristina Gutiérrez-Vázquez, Simon C. Robson, Lior Mayo, Soufiene Ghannam
Publikováno v:
Nat Neurosci
Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a9f44a7a0265fd83b88ffe6710bbe7
https://europepmc.org/articles/PMC8052632/
https://europepmc.org/articles/PMC8052632/
Autor:
Hania Kebir, Alexandre Prat, Clary B. Clish, Manon Blain, Chun-Cheih Chao, Bonny Patel, Marco Prinz, Nathalie Pochet, Jack P. Antel, Steffen Jung, Nikolaus D. Obholzer, Lior Mayo, Guillermo Izquierdo, Jorge I. Alvarez, Niroshana Anandasabapathy, Maisa C. Takenaka, Jessica E. Kenison, Raymond Yan, Lukas Bunse, Francisco J. Quintana, Ivan D. Mascanfroni, Veit Rothhammer
Publikováno v:
Nature Medicine. 22:586-597
After upregulation of AHR in astrocytes by type I interferons, commensal-microbe-derived metabolites of dietary tryptophan act on astrocytes to suppress CNS inflammation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cf602f583f54dd4cc9f6806b2221bc
https://doi.org/10.1038/nm.4106
https://doi.org/10.1038/nm.4106
Autor:
Shafiuddin Siddiqui, Clary B. Clish, Yan Wu, Leo E. Otterbein, Bonny Patel, Avner Priel, Francisco J. Quintana, Simon C. Robson, Fan Pan, Alexandre S. Basso, Ivan D. Mascanfroni, Drew M. Pardoll, Jessica E. Kenison, Ada Yeste, Maisa C. Takenaka
Publikováno v:
Nature Medicine. 21:638-646
Our understanding of the pathways that regulate lymphocyte metabolism, as well as the effects of metabolism and its products on the immune response, is still limited. We report that a metabolic program controlled by the transcription factors hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b565261aaa04f3e05f509e0d9ae7b8b9
https://doi.org/10.1038/nm.3868
https://doi.org/10.1038/nm.3868
Autor:
Sunia A. Trauger, Alexandre Prat, Francisco J. Quintana, Jack P. Antel, Benjamin Ellezam, Pia Kivisäkk, Meghan Nadeau, Ivan D. Mascanfroni, Rohit Bakshi, Jorge I. Alvarez, Bonny Patel, Lior Mayo, Howard L. Weiner, Manon Blain, Keith Kallas, Ada Yeste
Publikováno v:
Nature Medicine. 20:1147-1156
Astrocytes have complex roles in health and disease, thus it is important to study the pathways that regulate their function. Here we report that lactosylceramide (LacCer) synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce366ede2420ba57ee9d87e84ef3b22
https://doi.org/10.1038/nm.3681
https://doi.org/10.1038/nm.3681
Publikováno v:
Cell Death & Differentiation. 22:215-224
Dendritic cells (DCs) are professional antigen-presenting cells that control the generation of adaptive immunity. Consequently, DCs have a central role in the induction of protective immunity to pathogens and also in the pathogenic immune response re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2829926cdbfed3a28e560ddbc08f8e68
https://doi.org/10.1038/cdd.2014.125
https://doi.org/10.1038/cdd.2014.125
Autor:
Fernanda Stephanie Santos, Ivan D. Mascanfroni, Aleixo M. Muise, J. Rodrigo Mora, Scott B. Snapper, Jeremy A. Goettel, Mouna Ibourk, Laurie S. Conklin, Christen L. Ebens, Raz Somech, Ziad Al Adham, Batia Weiss, Werner Müller, Evan Conaway, Sydney Lavoie, Naresh Singh Redhu, Johanna C. Escher, Janneke N. Samsom, Deanna D. Nguyen, Christoph Klein, Bruce H. Horwitz, Mark Sherlock, Dror S. Shouval, Francisco J. Quintana, Amlan Biswas, Alexandre Rodrigues Ferreira, Atul K. Bhan, Katelyn McCann, Rita Beier
Publikováno v:
Europe PubMed Central
Immunity, 40(5), 706-719. Cell Press
Immunity, 40(5), 706-719. Cell Press
Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg) cells are each independently required to maintain immune tolerance. Here we show that IL-10 sensing by innate immune cells, independent of its effects on T cells, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc4193cb1c02a5044ee38afada31a1c
https://doi.org/10.1016/j.immuni.2014.03.011
https://doi.org/10.1016/j.immuni.2014.03.011
Autor:
Margaret A. Shipp, Enrique A. Mesri, Juan J. Garcia-Vallejo, Carlos Bais, Gabriel A. Rabinovich, Diego O. Croci, Santiago P. Méndez-Huergo, Ivan D. Mascanfroni, Juan P. Cerliani, Jing Ouyang, Melissa R. Junttila, Tomás Dalotto-Moreno, Julio J. Caramelo, Marta A. Toscano, Mariana Salatino, Sebastián Dergan-Dylon
Publikováno v:
Croci, D O, Cerliani, J P, otto-Moreno, T, Mendez-Huergo, S P, Mascanfroni, I D, rgan-Dylon, S, Toscano, M A, Caramelo, J J, Garcia Vallejo, J J, Ouyang, J, Mesri, E A, Junttila, M R, Bais, C, Shipp, M A, Salatino, M & Rabinovich, G A 2014, ' Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors ', Cell, vol. 156, no. 4, pp. 744-758 . https://doi.org/10.1016/j.cell.2014.01.043
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell, 156(4), 744-758. Cell Press
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell, 156(4), 744-758. Cell Press
The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we identify a glycosylation-dependent pathway that compensates for the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5abd84e4bd6b32080e37b8ae1009d9
https://doi.org/10.1016/j.cell.2014.01.043
https://doi.org/10.1016/j.cell.2014.01.043
Autor:
Ivan D. Mascanfroni, David A. Reardon, Jack P. Antel, Gad Getz, Luke M. Healy, Francisco J. Quintana, Mauricio F. Farez, Veit Rothhammer, Maisa C. Takenaka, Michael A. Wheeler, Cristina Gutiérrez-Vázquez, Hailei Zhang, Jessica E. Kenison, Simon C. Robson, Lior Mayo, Soufiene Ghannam, Chun-Cheih Chao, Kalil Alves de Lima, Tyler Vandeventer, Sonja Rothweiler, Emily C. Tjon, David H. Sherr, Howard L. Weiner, Alexandre Prat, Galina Gabriely, Stephanie Zandee, Andreia Barroso
Publikováno v:
Nat Neurosci
Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4859869df4eccdefe630c6ccba688e
https://doi.org/10.1038/s41593-019-0446-8
https://doi.org/10.1038/s41593-019-0446-8
Autor:
Bonny Patel, Jessica E. Kenison, Jenny Aurielle B. Babon, Sally C. Kent, Ada Yeste, Megan E DeNicola, David Pozo, Francisco J. Quintana, Ann-Marcia Tukpah, Maisa C. Takenaka, Meghan Nadeau, Ivan D. Mascanfroni
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Yeste, Ada et al.
Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex vivo-differentiated FoxP3 regulatory T
Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex vivo-differentiated FoxP3 regulatory T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0740b8fcbbeca43e92be655400eb9c4
http://hdl.handle.net/10261/165318
http://hdl.handle.net/10261/165318