Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ivan B. Lobov"'
Autor:
Chunxiang Tong, Nicholas W. Gale, Saathyaki Rajamani, George D. Yancopoulos, Jingtai Cao, Julia Lerner, Virginia Hughes, Zhe Li, Andrew J. Murphy, Eunice Cheung, Gavin Thurston, Carmelo Romano, Gabor Halasz, Ivan B. Lobov, Patricia Boland, Melissa G. Dominguez, Ron A. Deckelbaum
Publikováno v:
Angiogenesis
Angiogenesis is largely driven by motile endothelial tip-cells capable of invading avascular tissue domains and enabling new vessel formation. Highly responsive to Vascular Endothelial Growth-Factor-A (VEGFA), endothelial tip-cells also suppress angi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0787dffa46b5d148b47924d5512df6
https://doi.org/10.1007/s10456-019-09696-8
https://doi.org/10.1007/s10456-019-09696-8
Autor:
Li-Kun Phng, Sujata Rao, Richard A. Lang, Ivan B. Lobov, Michael Potente, Jennifer K. Ondr, Daniel Nyqvist, Jonathan D. Leslie, Gavin Thurston, Jane Babbage, Holger Gerhardt
Publikováno v:
Dev Cell
SummaryWhen and where to make or break new blood vessel connections is the key to understanding guided vascular patterning. VEGF-A stimulation and Dll4/Notch signaling cooperatively control the number of new connections by regulating endothelial tip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a7c534a9f0cbdc28e2ec28b2307418
https://doi.org/10.1016/j.devcel.2008.12.009
https://doi.org/10.1016/j.devcel.2008.12.009
Autor:
Kenneth Walsh, Sujata Rao, Jefferson E. Vallance, Ivan B. Lobov, Laura E. Benjamin, Shailaja Akunuru, Richard A. Lang, Ichiro Shiojima, Kaoru Tsujikawa
Publikováno v:
Development. 134:4449-4458
Macrophages have a critical function in the recognition and engulfment of dead cells. In some settings, macrophages also actively signal programmed cell death. Here we show that during developmentally scheduled vascular regression,resident macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ab9ed65eed556dbcd51feb93a47781
https://doi.org/10.1242/dev.012187
https://doi.org/10.1242/dev.012187
Autor:
Jason Yasenchack, Joyce McClain, Rostislav Chernomorsky, Wojtek Auerbach, Joseph M. Cruz, Melissa G. Dominguez, Ron A. Deckelbaum, Thomas M. DeChiara, William Pouyemirou, Peter Matthew Lengyel, Samuel Davis, Kieran Feeley, Ian A. Mellis, Dore Anthony T, Andrew J. Murphy, Peter Yang, Trikaldarshi Persaud, Rojas Jose F, Lily Huang, Yuhong Zhang, Nicholas W. Gale, Gustavo Droguett, Ivan B. Lobov, George D. Yancopoulos, Sarah J. Hatsell, Aris N. Economides, LiQin Xie, Dimitris Skokos, David Frendewey, David M. Valenzuela, Evangelos Pefanis, Sean Stevens, Susan D. Croll, Esther Latres
Conditional mutagenesis is becoming a method of choice for studying gene function, but constructing conditional alleles is often laborious, limited by target gene structure, and at times, prone to incomplete conditional ablation. To address these iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701cb87f03c27b39441d4dcc38339ea9
https://europepmc.org/articles/PMC3752204/
https://europepmc.org/articles/PMC3752204/
Autor:
George D. Yancopoulos, Nicholas J. Papadopoulos, Jingtai Cao, Aris N. Economides, Rajeev Wudali, Gabor Halasz, Hsin C. Lin, Stanley J. Wiegand, Eunice Cheung, Yi Wei, Ivan B. Lobov
Publikováno v:
Blood. 117(24)
Blood vessel remodeling is crucial to the formation of the definitive vasculature, but little is known about the mechanisms controlling this process. We show that Delta-like ligand 4 (Dll4)/Notch pathway regulates vessel regression in normal patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac34115e0aeb450798ec9262dbccb20f
https://pubmed.ncbi.nlm.nih.gov/21498671
https://pubmed.ncbi.nlm.nih.gov/21498671
Autor:
Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly, Gavin Thurston, John S. Rudge, Stanley J. Wiegand, Nicholas W. Gale, George D. Yancopoulos
Publikováno v:
Angiogenesis ISBN: 9780387715179
The process of angiogenesis, be it physiological or pathological, requires the coordinated interplay of a variety of vascular growth factor systems. Many preclinical models, and more recently several clinical trials, have shown that vascular endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb7897637c0ba0ee39a90d01b7517b75
https://doi.org/10.1007/978-0-387-71518-6_19
https://doi.org/10.1007/978-0-387-71518-6_19
Autor:
R.A. Renard, Nicholas W. Gale, George D. Yancopoulos, Stanley J. Wiegand, Ivan B. Lobov, Nick Papadopoulos, Gavin Thurston
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(9)
Genetic deletion studies have shown that haploinsufficiency of Delta-like ligand (Dll) 4, a transmembrane ligand for the Notch family of receptors, results in major vascular defects and embryonic lethality. To better define the role of Dll4 during va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f998190e0afb8d9c51a93ff6a14e08b
https://pubmed.ncbi.nlm.nih.gov/17296940
https://pubmed.ncbi.nlm.nih.gov/17296940
Autor:
Donald A. Glass, Thomas L. Carroll, Edward E. Morrisey, Masataka Ito, Jennifer K. Ondr, Richard A. Lang, Ivan B. Lobov, Gerard Karsenty, Millan S. Patel, Jefferson E. Vallance, Sujata Rao, Andrew P. McMahon, Weiguo Shu, Savita Kurup
Publikováno v:
Nature. 437(7057)
Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca85f6bb6548510469d01ab59bd93fdb
https://pubmed.ncbi.nlm.nih.gov/16163358
https://pubmed.ncbi.nlm.nih.gov/16163358
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(17)
Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis, blood vessel maturation, and vascular endothelium integrity. It has been proposed that angiopoietins 1 (Ang1) and 2 (Ang2) are pro- and anti-angiogenic owin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7408db1d26dd94d9cefd5e20e97ab05b
https://pubmed.ncbi.nlm.nih.gov/12163646
https://pubmed.ncbi.nlm.nih.gov/12163646
Publikováno v:
Journal of Anti-Aging Medicine; Sep2003, Vol. 6 Issue 3, p205-218, 14p