Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ivan B Yanachkov"'
Autor:
Hung Chang, Ivan B Yanachkov, Edward J Dix, Milka Yanachkova, Youfu Li, Marc R Barnard, George E Wright, Alan D Michelson, Andrew L Frelinger
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94780 (2014)
Diadenosine tetraphosphate (Ap4A), a constituent of platelet dense granules, and its P1,P4-dithio and/or P2,P3-chloromethylene analogs, inhibit adenosine diphosphate (ADP)-induced platelet aggregation. We recently reported that these compounds antago
Externí odkaz:
https://doaj.org/article/874ef7e91dfb4fdb80321881bbbe4d83
Autor:
Alan D. Michelson, Ivan B. Yanachkov, Milka Yanachkova, George E. Wright, Karin Przyklenk, Elena Smolensky Koganov, Andrew L. Frelinger
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8507e7bc26557ba7147268d684e2a2c2
https://doi.org/10.1038/s41598-018-35956-6
https://doi.org/10.1038/s41598-018-35956-6
Autor:
Milka Yanachkova, George E. Wright, Karin Przyklenk, Andrew L. Frelinger, Ivan B. Yanachkov, Alan D. Michelson, Elena Smolensky Koganov
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) P2Y12 receptor antagonist reduces ischemic events in patients with acute coronary syndrome. Previous evidence from our group, obtained in a preclinical model of recurrent plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0543bc85748bb0098d5a2ef9d34a04c
https://doi.org/10.1038/s41598-018-32797-1
https://doi.org/10.1038/s41598-018-32797-1
Autor:
Ivan B. Yanachkov, Anna M. Krichevsky, David Tabatadze, Laura J. Stevens, Yekaterina Tabatadze, George E. Wright, Milka Yanachkova, Boris Zavizion, Valeri Metelev
There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle. We addressed this problem by developing a new approach for ON charge neutralization in which multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393fd3d80e79e132a3cbaae9cc62ceba
https://europepmc.org/articles/PMC5696787/
https://europepmc.org/articles/PMC5696787/
Publikováno v:
Letters in Organic Chemistry. 11:470-473
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c74e3b746b43940d04e21255cf214d
https://doi.org/10.2174/1570178611666140219004433
https://doi.org/10.2174/1570178611666140219004433
Autor:
Surong Zhang, George E. Wright, Paul C. Zamecnik, Valeri Metelev, Ivan B. Yanachkov, Alexei A. Bogdanov, Katherine Pierson, David Tabatadze
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 27:157-172
A novel thymidine phosphoramidite synthon was synthesized and successfully used for incorporation of primary amino groups, attached through a triethylene glycol linker to the internucleoside phosphates, at desired locations during automated oligodeox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f349f4724d0afd60137a1a805a58cf
https://doi.org/10.1080/15257770701795938
https://doi.org/10.1080/15257770701795938
Autor:
George E. Wright, Ivan B. Yanachkov, Alan D. Michelson, Joseph M. Wider, Milka Yanachkova, Andrew L. Frelinger, Karin Przyklenk, Thomas Gremmel, Vishnu V Undyala
Objective— Unlike currently approved adenosine diphosphate receptor antagonists, the new diadenosine tetraphosphate derivative GLS-409 targets not only P2Y 12 but also the second human platelet adenosine diphosphate receptor P2Y 1 and may, therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90520fb78c1edadf1df47c4c3f1a99a5
https://europepmc.org/articles/PMC4767596/
https://europepmc.org/articles/PMC4767596/
Autor:
George E. Wright, Edward J. Dix, Andrew L. Frelinger, Alan D. Michelson, Ivan B. Yanachkov, Milka Yanachkova, Thomas Gremmel, Michelle A. Berny-Lang, Hung Chang
Currently approved platelet adenosine diphosphate (ADP) receptor antagonists target only the platelet P2Y12 receptor. Moreover, especially in patients with acute coronary syndromes, there is a strong need for rapidly acting and reversible antiplatele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6273cb73304d22dac7cea387d5dac14
https://europepmc.org/articles/PMC4674339/
https://europepmc.org/articles/PMC4674339/
Autor:
Federico Focher, Milka Yanachkova, George E. Wright, Lida Savi, Timothy P. Foster, Edward J. Dix, M Dulfary Sanchez, Sofya Dvoskin, Wei-Chu Xu, Ivan B. Yanachkov
Publikováno v:
Antiviral chemistrychemotherapy. 24(2)
Background Because guanine-based herpes simplex virus thymidine kinase inhibitors are not orally available, we synthesized various 6-deoxy prodrugs of these compounds and evaluated them with regard to solubility in water, oral bioavailability, and ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274728625846314ca7f50355b25cf80a
https://pubmed.ncbi.nlm.nih.gov/26463822
https://pubmed.ncbi.nlm.nih.gov/26463822
Autor:
George E. Wright, Elena Smolensky Koganov, Andrew L. Frelinger, Karin Przyklenk, Milka Yanachkova, Ivan B. Yanachkov, Alan D. Michelson
Publikováno v:
Blood. 130:630-630
Introduction. Dual antiplatelet therapy with aspirin and an adenosine diphosphate (ADP) P2Y12 receptor inhibitor is a mainstay of pharmacological therapy in acute coronary syndromes. GLS-409 is a novel diadenosine tetraphosphate derivative that inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29609490003cc5feeb59832db0a4676c
https://doi.org/10.1182/blood.v130.suppl_1.630.630
https://doi.org/10.1182/blood.v130.suppl_1.630.630