Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ivan A. Bespalov"'
Autor:
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mett et al. describe development of GP532, a substantially deimmunized derivative of Toll-like receptor 5 (TLR5) agonist entolimod. GP532 has mutations eliminating key B- and T-cell epitopes and an inflammasome-activating domain yet remains a potent
Externí odkaz:
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Autor:
Alexandra V. Vylegzhanina, Ivan A. Bespalov, Ksenia A. Novototskaya-Vlasova, Brandon M. Hall, Anatoli S. Gleiberman, Han Yu, Olga V. Leontieva, Katerina I. Leonova, Oleg V. Kurnasov, Andrei L. Osterman, Grace K. Dy, Alexey A. Komissarov, Elena Vasilieva, Jeff Gehlhausen, Akiko Iwasaki, Christine B. Ambrosone, Takemasa Tsuji, Junko Matsuzaki, Kunle Odunsi, Ekaterina L. Andrianova, Andrei V. Gudkov
LINE-1 (L1), the most abundant family of autonomous retrotransposons occupying over 17% of human DNA, is epigenetically silenced in normal tissues but frequently derepressed in cancer, suggesting that L1-encoded proteins may act as tumor-associated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8477abcfdeea873bdfbc1aaddff4cbf4
https://doi.org/10.1101/2023.02.03.526997
https://doi.org/10.1101/2023.02.03.526997
Autor:
Craig M. Brackett, Catherine Burkhart, Ilia Toshkov, Andrei L. Osterman, Ivan A. Bespalov, Andrei Purmal, Vadim L. Mett, Andrei V. Gudkov, Lyudmila G. Burdelya, Yakov N. Kogan, Anatoli S. Gleiberman, Ekaterina L. Andrianova, Ivan Molodtsov, Oleg V. Kurnasov
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
The Toll-like receptor 5 (TLR5) agonist entolimod, a derivative of Salmonella flagellin, has therapeutic potential for several indications including radioprotection and cancer immunotherapy. However, in Phase 1 human studies, entolimod induced a rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdef2dd5c9aac4df928eea9fe09e4c96
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
https://doaj.org/article/bcafc6dab7b74c02bc2aec45e9ac993a
Autor:
Elena A. Komarova, Ellen Karasik, Bryan Gillard, Anatoly S. Gleiberman, M Bapardekar-Nair, Oleg V. Kurnasov, Semra Aygun-Sunar, Christopher Johnson, Vadim L. Mett, Andrei L. Osterman, Andrei V. Gudkov, Carl Morrison, Ivan A. Bespalov, Ilya Toshkov, Craig M. Brackett, Kellee F. Greene, Barbara A. Foster, Patricia Stanhope-Baker, Michael T. Moser
Publikováno v:
Oncogene
Toll-like receptor 5 (TLR5) is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered flagellin derivatives, have been shown to have potent antitumor and metastasis-suppressive effects in multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f554da51ebc5120ef78dfc73b88db3e8
https://doi.org/10.1038/onc.2017.346
https://doi.org/10.1038/onc.2017.346
Autor:
Richard Trauger, Ivan A. Bespalov, Mary-Ellen Harper, Jeffrey R Rogers, Minda Vendemelio, Richard M. Bartholomew, Robert J. Melamede, Ye Liu, Dennis J. Carlo, Robert E. Camley, Jack L. Leahy, Amanda M George, Andreas Antoniou, Alicia Russo, Gregory L. Gibbs, Azhar M. Shaikh, Elizabeth Villalobos-Menuey, Jami Kupperman, M. Karen Newell, Susan S. Wallace, Evan W. Newell
Publikováno v:
The FASEB Journal. 16:1550-1557
Acquired or inherent drug resistance is the major problem in achieving successful cancer treatment. However, the mechanism(s) of pleiotropic drug resistance remains obscure. We have identified and characterized a cellular metabolic strategy that diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e65fa299bd791433a95efab2867aa2
https://doi.org/10.1096/fj.02-0541com
https://doi.org/10.1096/fj.02-0541com
Autor:
Rebecca L. Persinger, Ivan A. Bespalov, Robert J. Melamede, Susan S. Wallace, Douglas J. Taatjes, Yvonne M. W. Janssen-Heininger
Publikováno v:
Experimental Gerontology. 36:1483-1494
The presence of 8-oxoguanine (8-oxoG) in DNA is considered a marker of oxidative stress and DNA damage. Numerous biochemical techniques have been described for its detection in cells or tissues. Although these approaches are quantitative, they do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedc7d4b7a8ca657ee400c170609323b
https://doi.org/10.1016/s0531-5565(01)00134-6
https://doi.org/10.1016/s0531-5565(01)00134-6
Publikováno v:
Toxicology. 161:25-38
This study evaluated the effects of cadmium (Cd) adaptation in cultured alveolar epithelial cells on oxidant-induced DNA damage and its subsequent repair. Using the comet assay, we determined that lower levels of DNA damage occurred in Cd-adapted cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a395330ac36f34ce54aca0d5ca09557e
https://doi.org/10.1016/s0300-483x(00)00419-4
https://doi.org/10.1016/s0300-483x(00)00419-4
Autor:
Kenneth B. Beckman, Bruce N. Ames, Susan S. Wallace, Douglas J. Taatjes, Ivan A. Bespalov, Rebecca P Soultanakis, Robert J. Melamede, Yvonne M. W. Janssen-Heininger
Publikováno v:
Free Radical Biology and Medicine. 28:987-998
The presence of 8-oxoguanine (8-oxoG) in DNA is considered a marker of oxidative stress and DNA damage. We describe a multifluorescence technique to detect the localization of 8-oxoG in both nuclear and mitochondrial DNA using a mouse recombinant Fab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169fe0a14c485a626ef177829cebe175
https://doi.org/10.1016/s0891-5849(00)00185-4
https://doi.org/10.1016/s0891-5849(00)00185-4
Autor:
Anatoly Zhitkovich, Mindy Reynolds, Volkan Gurel, Tatiana Johnston, Elizabeth Peterson-Roth, Haley L. Menard, Ivan A. Bespalov
Publikováno v:
Cancer research. 69(3)
Mismatch repair (MMR) strongly enhances cyto- and genotoxicity of several chemotherapeutic agents and environmental carcinogens. DNA double-strand breaks (DSB) formed after two replication cycles play a major role in MMR-dependent cell death by DNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fe4d6a6b7d6a2a6aff28e5a49158c5
https://pubmed.ncbi.nlm.nih.gov/19141647
https://pubmed.ncbi.nlm.nih.gov/19141647
Autor:
Anatoli S. Gleiberman, Ivan A. Bespalov, Elena Feinstein, Vadim I. Krivokrysenko, Peter Krasnov, Ilia Toshkov, Mark H. Whitnall, Inna Shyshynova, Andrei Purmal, Alexander N. Shakhov, Andrei V. Gudkov, Vijay K. Singh, Ratan K. Maitra, Natalya V. Narizhneva
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0135388 (2015)
PLoS ONE, Vol 10, Iss 9, p e0135388 (2015)
There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in nuclear emergencies. An ideal MRC would be effective even when administered well after radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1065e9b7e1c732e488fe294d55cf4f93
https://doi.org/10.1371/journal.pone.0135388
https://doi.org/10.1371/journal.pone.0135388