Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Ivan Nestorov"'
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Nick van derMunnik, Xiao Tong, Satish Eraly, Zdenek Berger, Danielle Graham, Toby Ferguson, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 196-206 (2023)
Abstract Phosphorylated neurofilament heavy subunit (pNfH) has been recently identified as a promising biomarker of disease onset and treatment efficacy in spinal muscular atrophy (SMA). This study introduces a quantitative systems pharmacology model
Externí odkaz:
https://doaj.org/article/9c84e240cf754f71aacd8847664a671a
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Michael Monine, Xiao Tong, Satish Eraly, Eric Masson, Toby Ferguson, Alexander McCampbell, Danielle Graham, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 4, Pp 447-457 (2022)
Abstract Neurofilaments (Nfs) are the major structural component of neurons. Their role as a potential biomarker of several neurodegenerative diseases has been investigated in past years with promising results. However, even under physiological condi
Externí odkaz:
https://doaj.org/article/de1ae59bb53d404daed33a212cd550f8
Autor:
Lin Lin, Fei Hua, Cristian Salinas, Carissa Young, Thierry Bussiere, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 362-372 (2022)
Abstract Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory and cognitive function. Dysregulation of the amyloid‐β (Aβ) pathway and amyloid plaque accumulation in the brain are hallmarks of AD. Aducanumab
Externí odkaz:
https://doaj.org/article/7f7bb9c94560451a90a1143017ac5a1c
Autor:
Kumar Kandadi Muralidharan, Xiao Tong, Kenneth G. Kowalski, Raj Rajagovindan, Lin Lin, Samantha Budd Haberlain, Ivan Nestorov
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 7-19 (2022)
Abstract Aducanumab is a human immunoglobulin G1 anti‐amyloid beta (Aβ) antibody currently being evaluated for potential treatment of patients with early Alzheimer’s disease. This paper describes the relationship between the population pharmacok
Externí odkaz:
https://doaj.org/article/6a0a7cf76a734c6fab8a7a9f6a676938
Publikováno v:
Geodetski Vestnik, Vol 64, Iss 02, Pp 214-226 (2020)
There is an increasing need for pan-European spatial datasets, mainly to support the common European Union policies. This has inevitably raised demands for adopting pan-European cartographic projections to visualize the spatial data. The Map Projecti
Externí odkaz:
https://doaj.org/article/3cc7c09c0359494aadb269b6b9d3cdc0
Autor:
Kumar Kandadi Muralidharan, Kenneth G. Kowalski, Xiao Tong, Samantha Budd Haeberlein, Rajasimhan Rajagovindan, Ivan Nestorov
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 50:45-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca54b16e0d9ecd18d92b8dbb2747d2c5
https://doi.org/10.1007/s10928-022-09839-3
https://doi.org/10.1007/s10928-022-09839-3
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Nick van der Munnik, Xiao Tong, Satish Eraly, Zdenek Berger, Danielle Graham, Toby Ferguson, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:196-206
Phosphorylated neurofilament heavy subunit (pNfH) has been recently identified as a promising biomarker of disease onset and treatment efficacy in spinal muscular atrophy (SMA). This study introduces a quantitative systems pharmacology model represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b471dd83b607c4a4f67d297e9a4dfd2f
https://doi.org/10.1002/psp4.12890
https://doi.org/10.1002/psp4.12890
Autor:
Konstantinos Biliouris, Puneet Gaitonde, Wei Yin, Daniel A. Norris, Yanfeng Wang, Scott Henry, Robert Fey, Ivan Nestorov, Stephan Schmidt, Mark Rogge, Lawrence J. Lesko, Mirjam N. Trame
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 9, Pp 581-592 (2018)
A pharmacokinetic (PK) model was developed for nusinersen, an antisense oligonucleotide (ASO) that is the first approved treatment for spinal muscular atrophy (SMA). The model was built with data from 92 nonhuman primates (NHPs) following intrathecal
Externí odkaz:
https://doaj.org/article/b2b051a9f867456392cdfdba33f08ea2
Autor:
Qin Wang, Luisette Delva, Paul H. Weinreb, Robert B. Pepinsky, Danielle Graham, Elvana Veizaj, Anne E. Cheung, Weiping Chen, Ivan Nestorov, Ellen Rohde, Robin Caputo, Geoffrey M. Kuesters, Tonika Bohnert, Liang-Shang Gan
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Many studies have focused on the challenges of small molecule uptake across the blood–brain barrier, whereas few in-depth studies have assessed the challenges with the uptake of antibodies into the central nervous system (CNS).
Externí odkaz:
https://doaj.org/article/d36a79f39c3e4673962d0976b38bc14c
Autor:
Kumar Kandadi, Muralidharan, Sravan, Karumanchi, Kenneth G, Kowalski, Patrick, Burkett, Sunny, Chapel, Raj, Rajagovindan, Ivan, Nestorov
Publikováno v:
The Journal of Clinical Pharmacology. 62:1030-1046
Amyloid-related imaging abnormalities with edema (ARIA-E) have been reported in patients with early Alzheimer disease treated with aducanumab. ARIA-E incidence has been observed to be dependent on both dose and apolipoprotein E4 carrier status. A tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d43193caed65559b3188037b55b328c
https://doi.org/10.1002/jcph.2047
https://doi.org/10.1002/jcph.2047