Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Ivan, Votruba"'
Autor:
Jindřich Fanfrlík, Radek Pohl, Jiřina Stolaříková, Petr Džubák, Petr Nauš, Petr Konečný, Jiří Dostál, Hana Dvořáková, Ivan Votruba, Marian Hajduch, Aleš Hnízda, Jiří Brynda, Michal Hocek, Helena Zábranská, Pavlína Řezáčová, Vaclav Veverka, Aurelie Bourderioux, Iva Pichová, Michal Dušek, Jan Snášel
Publikováno v:
Journal of Medicinal Chemistry
Adenosine kinase (ADK) from Mycobacterium tuberculosis (Mtb) was selected as a target for design of antimycobacterial nucleosides. Screening of 7-(het)aryl-7-deazaadenine ribonucleosides with Mtb and human (h) ADKs and testing with wild-type and drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643502593686ff8aed334065cc317714
https://doi.org/10.1021/jm500497v
https://doi.org/10.1021/jm500497v
Autor:
Gina Bahador, Pavla Perlíková, Tomáš Cihlář, Petr Nauš, Aurelie Bourderioux, Radek Pohl, Michal Hocek, Ivan Votruba, Gabriel Birkus, Lenka Poštová Slavětínská
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:5202-5214
A series of novel sugar-modified derivatives of cytostatic 7-hetaryl-7-deazaadenosines (2 ′ - C -methylribonucleosides, 2 ′ -deoxy-2 ′ -fluoroarabinonucleosides, arabinonucleosides and 2 ′ -deoxyribonucleosides) was prepared and screened for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd2625cf81b00dc81a142adebddee74
https://doi.org/10.1016/j.bmc.2012.07.003
https://doi.org/10.1016/j.bmc.2012.07.003
Publikováno v:
Plant Cell, Tissue and Organ Culture (PCTOC). 110:63-68
Antiviral effects of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP, and ribavirin on double-stranded DNA Cauliflower mosaic virus (CaMV) were evaluated in Brassica pekinensis plants grown in vitro on liquid medium. A double-antibody sandwic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5dc075fc579ed45d9d7d0b9a9d7ae76
https://doi.org/10.1007/s11240-012-0130-0
https://doi.org/10.1007/s11240-012-0130-0
Autor:
Marika Matousova, Miroslav Otmar, Jana Günterová, Eva Tloušťová, Helena Mertlíková-Kaiserová, Ivan Votruba
Publikováno v:
Epigenetics. 6:769-776
Restoration of transcriptionally silenced genes by means of methyltransferases inhibitors plays a crucial role in the current therapy of myelodysplastic syndromes and certain types of leukemias. A comparative study of hypomethylating activities of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2232a8ba236b8ae8018be7c12a3a7bdf
https://doi.org/10.4161/epi.6.6.16215
https://doi.org/10.4161/epi.6.6.16215
Autor:
Martin Dračínský, Zlatko Janeba, Jan Balzarini, Blanka Klepetářová, Ivan Votruba, Antonín Holý, Ondřej Baszczyňski, Petr Jansa, Erik De Clercq
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:2114-2124
An efficient method for the synthesis of N(9)-[3-fluoro-2-(phosphonomethoxy)propyl] (FPMP) derivatives of purine bases has been developed. Both (R)- and (S)-enantiomers of the N(6)-substituted FPMP derivatives of adenine and 2,6-diaminopurine were pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16574d9867c5e9f6075f02047b92d855
https://doi.org/10.1016/j.bmc.2011.02.050
https://doi.org/10.1016/j.bmc.2011.02.050
Autor:
Antonín Holý, Kateřina Křížová, Jaroslav Fulneček, Ivan Votruba, Roman Matyášek, Aleš Kovařík
Publikováno v:
Molecular Genetics and Genomics. 285:225-236
Developmental processes are closely connected to certain states of epigenetic information which, among others, rely on methylation of chromatin. S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are key cofactors of enzymes catalyzing DNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb54fcc7d958376d361fb56e6774d4f
https://doi.org/10.1007/s00438-011-0601-8
https://doi.org/10.1007/s00438-011-0601-8
Publikováno v:
Collection of Czechoslovak Chemical Communications. 76:1487-1527
While direct Sonogashira coupling of 6-halopurines with methyl propiolate and with propargyl aldehyde was not successful, the corresponding orthoester and propargyl aldehyde diethylacetal reacted smoothly. Such prepared orthoester was then converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aa8fccde1ba2b8757363d0d6986c9c8
https://doi.org/10.1135/cccc2011176
https://doi.org/10.1135/cccc2011176
Autor:
Zlatko Janeba, Petr Jansa, Ivan Votruba, Petr Špaček, Blanka Klepetářová, Martin Dračínský, Petra Břehová
Publikováno v:
Collection of Czechoslovak Chemical Communications. 76:1121-1131
The preparation of several triazolo acyclic nucleosides and triazolo acyclic nucleoside phosphonates is described. The synthetic methodology has been developed as an efficient one-pot Cu(I)-catalyzed azide alkyne Huisgen “click” cycloaddition. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c6f7f3d81d1c8f4d6fef098093f4d4
https://doi.org/10.1135/cccc2011074
https://doi.org/10.1135/cccc2011074
Autor:
Ivan Votruba, Ria Ameral, Helena Zábranská, Jan Snášel, Petr Nauš, Radek Pohl, Tomas Cihlar, Michal Hocek, Pavla Spácilová, Gabriel Birkus, Iva Pichová
Publikováno v:
ChemMedChem. 5:1386-1396
A series of cycloSal-phosphate prodrugs of a recently described new class of nucleoside cytostatics (6-hetaryl-7-deazapurine ribonucleosides) was prepared. The corresponding 2',3'-isopropylidene 6-chloro-7-deazapurine nucleosides were converted into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6205b32de1d5cc94c006e3c9cea16f17
https://doi.org/10.1002/cmdc.201000192
https://doi.org/10.1002/cmdc.201000192
Autor:
Marcel Špulák, Ondřej Krenk, Jiří Kuneš, Petr Šenel, Ivan Votruba, Lucie Tichotová, Milan Pour, Vladimír Buchta, Milan Nobilis
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:1988-2000
5-Acetoxymethyl-3-(4-bromophenyl)-2,5-dihydrofuran-2-one previously described as highly antifungally active was found to provide the corresponding 5-methylene derivative via an unusual DMSO-promoted elimination of the ester group at C5 under antifung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b446adb77ddc4318f3235eae6baefcff
https://doi.org/10.1016/j.bmc.2010.01.030
https://doi.org/10.1016/j.bmc.2010.01.030