Invasive cattle ticks in East Africa: morphological and molecular confirmation of the presence of Rhipicephalus microplus in south-eastern Uganda

Autor: Dennis Muhanguzi, Joseph Byaruhanga, Wilson Amanyire, Christian Ndekezi, Sylvester Ochwo, Joseph Nkamwesiga, Frank Norbert Mwiine, Robert Tweyongyere, Josephus Fourie, Maxime Madder, Theo Schetters, Ivan Horak, Nick Juleff, Frans Jongejan

Publikováno v: Parasites & Vectors, Vol 13, Iss 1, Pp 1-9 (2020)

Abstract Background Rhipicephalus microplus, an invasive tick species of Asian origin and the main vector of Babesia species, is considered one of the most widespread ectoparasites of livestock. The tick has spread from its native habitats on translo

Externí odkaz: https://doaj.org/article/b9b8438e78504fc995bb3c708be625d8

Vaccinia virus E3 protein prevents the antiviral action of ISG15.

Autor: Susana Guerra, Ana Cáceres, Klaus-Peter Knobeloch, Ivan Horak, Mariano Esteban

Publikováno v: PLoS Pathogens, Vol 4, Iss 7, p e1000096 (2008)

The ubiquitin-like modifier ISG15 is one of the most predominant proteins induced by type I interferons (IFN). In this study, murine embryo fibroblast (MEFs) and mice lacking the gene were used to demonstrate a novel role of ISG15 as a host defense m

Externí odkaz: https://doaj.org/article/98fdbd890b324c309bc7db84eacb8af0

Abstract 1723: CD4+ and CD8a+ PET imaging in syngeneic mouse models for prediction of immuno-therapeutic response

Autor: Carsten H. Nielsen, Thomas Tuxen Poulsen, Johan Lantto, Gunther R. Galler, Andreas Kjaer, Maria C. Melander, Ivan Horak, Camilla L. Christensen, Camilla Fröhlich, Lotte K. Kristensen, Michael Kragh

Publikováno v: Cancer Research. 78:1723-1723

Introduction: The clinical success of immune-checkpoint inhibitors in oncology has stimulated development of immune-based agents and revolutionized treatment for many types of cancer. With only a subpopulation of patients benefiting from immuno-thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c10d0fe72f1e9fafd873f69f8a838b8
https://doi.org/10.1158/1538-7445.am2018-1723

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

Autor: Charlotte Albæk, Majken Westergaard, Puja Sapra, Henrik Ørum, Henrik Daa Schrøder, Henrik Frydenlund, Lee M. Greenberger, Ivan Horak, David Filpula

Publikováno v: Greenberger, L M, Horak, I D, Filpula, D, Sapra, P, Westergaard, M, Frydenlund, H F, Albaek, C, Schrøder, H & Ørum, H 2008, ' A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth ', Molecular Cancer Therapeutics, vol. 7, no. 11, pp. 3598-608 . https://doi.org/10.1158/1535-7163.MCT-08-0510

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and glucose metabolism. Elevated expression of the α-subunit of HIF-1 (HIF-1α), which occurs in response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ada4f50e32d24b9b262f65b8f9b16c
https://doi.org/10.1158/1535-7163.mct-08-0510

Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin

Autor: Chien-Hsing Chang, Sailaja S. Vanama, Puja Sapra, David M. Goldenberg, Ivan Horak, Hans J. Hansen

Publikováno v: Blood. 106:4308-4314

Ranpirnase (Rap) is a cytotoxic ribonuclease (RNase) isolated from frog oocytes. Here we describe high antitumor activity of a novel immunotoxin, 2L-Rap-hLL1-gamma4P, composed of 2 Rap molecules, each fused to the N terminus of the light chain of hLL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9568d3b957395ee6b4f7d553887fb701
https://doi.org/10.1182/blood-2005-03-1033