Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Autor: Irina E. Antonescu, Maria Karlgren, Maria L. Pedersen, Ivailo Simoff, Christel A. S. Bergström, Sibylle Neuhoff, Per Artursson, Bente Steffansen, Carsten Uhd Nielsen

Publikováno v: Pharmaceutics, Vol 12, Iss 4, p 390 (2020)

Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport. In contrast, little is known about the eliminating mechan

Externí odkaz: https://doaj.org/article/98594dfdbdd9410b820f985d165d6cfa

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Autor: Martina Durcik, Andrej Emanuel Cotman, Žan Toplak, Štefan Možina, Žiga Skok, Petra Eva Szili, Márton Czikkely, Elvin Maharramov, Thu Hien Vu, Maria Vittoria Piras, Nace Zidar, Janez Ilaš, Anamarija Zega, Jurij Trontelj, Luis A. Pardo, Diarmaid Hughes, Douglas Huseby, Tália Berruga-Fernández, Sha Cao, Ivailo Simoff, Richard Svensson, Sergiy V. Korol, Zhe Jin, Francisca Vicente, Maria C. Ramos, Julia E. A. Mundy, Anthony Maxwell, Clare E. M. Stevenson, David M. Lawson, Björn Glinghammar, Eva Sjöström, Martin Bohlin, Joanna Oreskär, Sofie Alvér, Guido V. Janssen, Geert Jan Sterk, Danijel Kikelj, Csaba Pal, Tihomir Tomašič, Lucija Peterlin Mašič

Publikováno v: Durcik, M, Cotman, A E, Toplak, Ž, Možina, Š, Skok, Ž, Szili, P E, Czikkely, M, Maharramov, E, Vu, T H, Piras, M V, Zidar, N, Ilaš, J, Zega, A, Trontelj, J, Pardo, L A, Hughes, D, Huseby, D, Berruga-Fernández, T, Cao, S, Simoff, I, Svensson, R, Korol, S V, Jin, Z, Vicente, F, Ramos, M C, Mundy, J E A, Maxwell, A, Stevenson, C E M, Lawson, D M, Glinghammar, B, Sjöström, E, Bohlin, M, Oreskär, J, Alvér, S, Janssen, G V, Sterk, G J, Kikelj, D, Pal, C, Tomašič, T & Peterlin Mašič, L 2023, ' New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus ', Journal of medicinal chemistry, vol. 66, no. 6, pp. 3968-3994 . https://doi.org/10.1021/acs.jmedchem.2c01905
Journal of medicinal chemistry, 66(6), 3968-3994. American Chemical Society
Journal of Medicinal Chemistry
Journal of medicinal chemistry, str. 3968-3994 : Ilustr., Vol. 66, iss. 6, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, vol. 66, no. 6, pp. 3968-3994, 2023.

A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and topoisomerase IV were developed. The resulting compounds show excellent broad-spectrum antibacterial activities against Gram-positive Enterococcus faecalis, Enter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c3d01f7594899ad1504d0f95893f77
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-501871

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Autor: Per Artursson, Maria Pedersen, Carsten Uhd Nielsen, Ivailo Simoff, Irina E Antonescu, Sibylle Neuhoff, Maria Karlgren, Bente Steffansen, Christel A. S. Bergström

Publikováno v: Pharmaceutics
Pharmaceutics, Vol 12, Iss 390, p 390 (2020)
Antonescu, I E, Karlgren, M, Pedersen, M L, Simoff, I, Bergström, C A S, Neuhoff, S, Artursson, P, Steffansen, B & Nielsen, C U 2020, ' Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties : Implications for Renal Acamprosate Secretion and Drug-Drug Interactions ', Pharmaceutics, vol. 12, no. 4, 390 . https://doi.org/10.3390/pharmaceutics12040390
Volume 12
Issue 4

Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport. In contrast, little is known about the eliminating mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbdc6368ac6e4f9406d56de8f8dcddc
http://europepmc.org/articles/PMC7238232

Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1

Autor: Irina Antonescu, Maria Karlgren, Maria Pedersen, Ivailo Simoff, Christel Bergström, Sibylle Neuhoff, Per Artursson, Bente Steffansen, Carsten Uhd Nielsen

Publikováno v: Antonescu, I-E, Karlgren, M, Pedersen, M, Simoff, I, Bergström, C, Neuhoff, S, Artursson, P, Steffansen, B & Nielsen, C U 2019, ' Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1 ', Nordic POP 1st Annual Meeting, Oslo, Norway, 14/01/2019-16/01/2019 .
University of Southern Denmark

Introduction. Acamprosate is a BCS class III, non-metabolized, anionic drug substance for which the excretion mechanism is not fully understood. Intravenous administration in rats of acamprosate together with probenecid, a known substrate and inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3c30e54b2b5f0ac56d5fa80f27fc557f
https://portal.findresearcher.sdu.dk/da/publications/62df4eec-11fb-49e1-b423-e6eb67af0417

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Autor: Ivailo Simoff, Maria Karlgren, Stefan Oswald, Per Artursson, Markus Keiser

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(11)

Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9), i.e., CRISPR-Cas9, has been extensively used as a gene-editing technology during recent years. Unlike earlier technologies for gene editing or gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4367fcfaa26a95e3bc8dd366d67a8db9
https://pubmed.ncbi.nlm.nih.gov/30126863