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Akademický článek

Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1

Publikováno v: Molecular Oncology, Vol 17, Iss 12, Pp 2565-2583 (2023)

Mutations in the splicing factor 3b subunit 1 (SF3B1) gene are frequent in myelodysplastic neoplasms (MDS). Because the splicing process is involved in the production of circular RNAs (circRNAs), we investigated the impact of SF3B1 mutations on circR

Externí odkaz: https://doaj.org/article/cf124e1e1eda474f8d617a5629fc916b

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Noncoding RNAs and Their Response Predictive Value in Azacitidine-treated Patients With Myelodysplastic Syndrome and Acute Myeloid Leukemia With Myelodysplasia-related Changes

Autor: Michaela Dostalova, Merkerova, Jiri, Klema, David, Kundrat, Katarina, Szikszai, Zdenek, Krejcik, Andrea, Hrustincova, Iva, Trsova, Anh Vu, LE, Jaroslav, Cermak, Anna, Jonasova, Monika, Belickova

Publikováno v: Cancer Genomics Proteomics

Background/Aim: Prediction of response to azacitidine (AZA) treatment is an important challenge in hematooncology. In addition to protein coding genes (PCGs), AZA efficiency is influenced by various noncoding RNAs (ncRNAs), including long ncRNAs (lnc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92035afd9d4d1546d0af2868dbae0c6
https://doi.org/10.21873/cgp.20315

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Circular RNAs in Myelodysplastic Syndromes and Impact of SF3B1 Mutations on Their Expression

Autor: Jiri Klema, Katarina Szikszai, Andrea Hrustincova, Zdenek Krejcik, Monika Belickova, Iva Trsova, Michaela Dostalova Merkerova, David Kundrat, Jaroslav Cermak, Jitka Vesela, Monika Kaisrlikova

Publikováno v: Blood. 138:2590-2590

Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases with a high risk of transformation to acute myeloid leukemia (AML). One of the processes implicated in MDS pathogenesis is RNA splicing. Its alterations are caused by somatic mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9a817e8f536abadb83f2dd35af08f1b
https://doi.org/10.1182/blood-2021-149633

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