Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Iva Obadalová"'
Autor:
Jan Bosák, Martin Šíma, Tereza Krejčí, Iva Obadalová, Jaroslava Šmardová, Petr Kozlík, Tomáš Křížek, Josef Beránek, Tomáš Hauser, Ondřej Slanař
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract The bioavailability of rivaroxaban at the higher doses (15 and 20 mg) is considerably reduced when the drug is administered on an empty stomach. This can lead to inadequate anticoagulant effect, and therefore, it is recommended to use the hi
Externí odkaz:
https://doaj.org/article/a5bac16325a84301bee9ca4ced8a4c8a
Autor:
Stanislav Rádl, Iva Obadalová
Publikováno v:
ARKIVOC, Vol 2005, Iss 15, Pp 4-11 (2005)
Externí odkaz:
https://doaj.org/article/3988ba5519be46009c8fed1a355f6041
Publikováno v:
Synthesis. 46:899-908
Two synthetic approaches to the achiral quinoline fragment of simeprevir are described. Both approaches are based on the synthesis of methyl 4-hydroxy-7-methoxy-8-methylquinoline-2-carboxylate, protection of its 4-hydroxyl group, and construction of
Publikováno v:
ChemInform. 45
Two different approaches to the title compound which is a building block of the drug candidate simeprevir with specific HCV protease inhibitory activity are described.
Autor:
Iva Obadalová, Stanislav Radl
Publikováno v:
ChemInform. 35
Synthesis of 3-unsubstituted 1-alkyl- and 1-aryl-1,4-dihydroquinolin-4-ones from 2-nitroacetophenone via the corresponding 3-amino-1-(2-nitrophenyl)prop-2-en-1-ones and -but-2-en-1-ones by denitrocyclization reaction is described. The nucleophilic cy