Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Iva M, Tolić"'
Autor:
Marija Zekušić, Marina Bujić Mihica, Marija Skoko, Kruno Vukušić, Patrik Risteski, Jelena Martinčić, Iva M. Tolić, Krešo Bendelja, Snježana Ramić, Tamara Dolenec, Ivana Vrgoč Zimić, Dominik Puljić, Ivanka Petric Vicković, Renata Iveković, Ivanka Batarilo, Uršula Prosenc Zmrzljak, Alan Hoffmeister, Tiha Vučemilo
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Background Limbal stem cells (LSCs) are crucial for the regeneration of the corneal epithelium in patients with limbal stem cell deficiency (LSCD). Thus, LSCs during cultivation in vitro should be in highly homogeneous amounts, while potency
Externí odkaz:
https://doaj.org/article/1ea97ef887f741b2bd77b5d00bf8449d
Autor:
Mohammad Zeeshan, Edward Rea, Steven Abel, Kruno Vukušić, Robert Markus, Declan Brady, Antonius Eze, Ravish Rashpa, Aurelia C. Balestra, Andrew R. Bottrill, Mathieu Brochet, David S. Guttery, Iva M. Tolić, Anthony A. Holder, Karine G. Le Roch, Eelco C. Tromer, Rita Tewari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein scaffolds. Plasmodium spp., the causative agents of
Externí odkaz:
https://doaj.org/article/b48dddf02dd94fbda52d44cd32baa0e1
Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly
Autor:
Jurica Matković, Subhadip Ghosh, Mateja Ćosić, Susana Eibes, Marin Barišić, Nenad Pavin, Iva M. Tolić
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Mitotic spindle assembly is not fully understood. This work reveals that kinetochores drive the coarsening of a uniform microtubule array into bundles, which promote spindle formation and chromosome segregation fidelity.
Externí odkaz:
https://doaj.org/article/a778130e801347d59c9d611bac087f16
Publikováno v:
eLife, Vol 11 (2022)
The human mitotic spindle is made of microtubules nucleated at centrosomes, at kinetochores, and from pre-existing microtubules by the augmin complex. However, it is unknown how the augmin-mediated nucleation affects distinct microtubule classes and
Externí odkaz:
https://doaj.org/article/2245be649c4d4a319d992f34261ae797
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundles connecting the spi
Externí odkaz:
https://doaj.org/article/cbc4f1e76b9e4a74a07fb792f1075a81
Publikováno v:
eLife, Vol 10 (2021)
During metaphase, chromosome position at the spindle equator is regulated by the forces exerted by kinetochore microtubules and polar ejection forces. However, the role of forces arising from mechanical coupling of sister kinetochore fibers with brid
Externí odkaz:
https://doaj.org/article/4f0b8324913147a6bb786d728cd4cbd9
Autor:
Kruno Vukušić, Iva M. Tolić
Publikováno v:
Cells, Vol 11, Iss 9, p 1531 (2022)
The process of chromosome congression and alignment is at the core of mitotic fidelity. In this review, we discuss distinct spatial routes that the chromosomes take to align during prometaphase, which are characterized by distinct biomolecular requir
Externí odkaz:
https://doaj.org/article/ab7376a178de44728f9cf2179c5dfef3
Autor:
Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 in
Externí odkaz:
https://doaj.org/article/6c7f670a0f214d33b19b8f2d1e62ae20
Autor:
Hiral Shah, Marine Olivetta, Chandni Bhickta, Paolo Ronchi, Monika Trupinić, Eelco C. Tromer, Iva M. Tolić, Yannick Schwab, Omaya Dudin, Gautam Dey
Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope (NE) during cell division: disassembling the NE in an open mitosis or constructing an intranuclear spindle in a closed mitosis. Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db783861ad37c5657ed515e24d263af0
https://doi.org/10.1101/2023.05.10.540163
https://doi.org/10.1101/2023.05.10.540163
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1632-1645 (2016)
Pairing of homologous chromosomes is a crucial step in meiosis, which in fission yeast depends on nuclear oscillations. However, how nuclear oscillations help pairing is unknown. Here, we show that homologous loci typically pair when the spindle pole
Externí odkaz:
https://doaj.org/article/630c69d1d2864caa88b643bc7818c0f7