Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Iva B. Zovkic"'
Autor:
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A. Brimble, Samantha D. Creighton, Timothy A. B. McLean, Meaghan Hall, Krista A. Mitchnick, Jacqueline Zakaria, Thanh Phung, Anas Reda, Amanda M. Leonetti, Ashley Monks, Lara Ianov, Boyer D. Winters, Brandon J. Walters, Andrew M. Davidoff, Jennifer A. Mitchell, Iva B. Zovkic
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The structurally-unique histone variant, mH2A1, influences learning and memory in mice to a greater extent than a similar variant, mH2A2.
Externí odkaz:
https://doaj.org/article/d840a5d938684f1fae4467b25c62e8a3
Autor:
Minesh Kapadia, M. Firoz Mian, Donglai Ma, Craig P. Hutton, Amber Azam, Klotilda Narkaj, Chuanhai Cao, Breanna Brown, Bernadeta Michalski, David Morgan, Paul Forsythe, Iva B. Zovkic, Margaret Fahnestock, Boris Sakic
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Circulating autoantibodies and sex-dependent discrepancy in prevalence are unexplained phenomena of Alzheimer’s disease (AD). Using the 3xTg-AD mouse model, we reported that adult males show early manifestations of systemic auto
Externí odkaz:
https://doaj.org/article/7d635303ac54408691a9fbff0c069179
Autor:
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A. Brimble, Samantha D. Creighton, Timothy A. B. McLean, Meaghan Hall, Krista A. Mitchnick, Jacqueline Zakaria, Thanh Phung, Anas Reda, Amanda M. Leonetti, Ashley Monks, Lara Ianov, Boyer D. Winters, Brandon J. Walters, Andrew M. Davidoff, Jennifer A. Mitchell, Iva B. Zovkic
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/a2cbb085173249b3b824b77e9b19d7bc
Autor:
Gilda Stefanelli, Amber B. Azam, Brandon J. Walters, Mark A. Brimble, Caroline P. Gettens, Pascale Bouchard-Cannon, Hai-Ying M. Cheng, Andrew M. Davidoff, Klotilda Narkaj, Jeremy J. Day, Andrew J. Kennedy, Iva B. Zovkic
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1124-1131 (2018)
Summary: Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with ste
Externí odkaz:
https://doaj.org/article/9c12da0205304d89b9ae92c1b0d9e7ab
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6918 (2020)
The neuronal epigenome is highly sensitive to external events and its function is vital for producing stable behavioral outcomes, such as the formation of long-lasting memories. The importance of epigenetic regulation in memory is now well establishe
Externí odkaz:
https://doaj.org/article/5c443665fc2b4741a730b9ec1210c8f1
Autor:
Manjinder S. Cheema, Katrina V. Good, Bohyun Kim, Heddy Soufari, Connor O’Sullivan, Melissa E. Freeman, Gilda Stefanelli, Ciro Rivera Casas, Kristine E. Zengeler, Andrew J. Kennedy, Jose Maria Eirin Lopez, Perry L. Howard, Iva B. Zovkic, Jeffrey Shabanowitz, Deanna D. Dryhurst, Donald F. Hunt, Cameron D. Mackereth, Juan Ausió
Publikováno v:
Cells, Vol 9, Iss 5, p 1167 (2020)
The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many replication dependent (RD) members. The protein has been shown to be indispensable for surviv
Externí odkaz:
https://doaj.org/article/517b3db1d9174cdc83b82142f8ac91b1
Autor:
Iva B. Zovkic
Publikováno v:
Current Opinion in Neurobiology. 67:58-65
Nearly two decades of research on epigenetic mechanisms in the brain have demonstrated that epigenetic marks that were once thought to be relatively static are dynamically and reversibly regulated in the brain during memory formation. Here, we focus
Autor:
Cheryl M. McCormick, Iva B. Zovkic
Publikováno v:
Physiology & Behavior. 203:51-59
Estradiol moderates the effects of drugs of abuse in both humans and rodents. Estradiol's enhancement of behavioral effects resulting from high (>2.5mg/kg) doses of amphetamine is established in rats; there is less evidence for the role of estradiol
Autor:
Meaghan Hall, Mark A. Brimble, Andrew M. Davidoff, Brandon J. Walters, Iva B. Zovkic, Timothy A.B. McLean, Celeste B. Greer, Anas Reda, Amanda M. Leonetti, Patrick J. Murphy, Jacqueline M. Zakaria, Jennet Baumbach, Samantha D. Creighton, Gilda Stefanelli, Claire E. Makowski
Publikováno v:
Cell reports
SUMMARY Rapid removal of histone H2A.Z from neuronal chromatin is a key step in learning-induced gene expression and memory formation, but mechanisms underlying learning-induced H2A.Z removal are unclear. Anp32e was recently identified as an H2A.Z-sp
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6918, p 6918 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The neuronal epigenome is highly sensitive to external events and its function is vital for producing stable behavioral outcomes, such as the formation of long-lasting memories. The importance of epigenetic regulation in memory is now well establishe