Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Iván Méndez López"'
Autor:
Idoia Blanco-Luquin, Blanca Acha, Amaya Urdánoz-Casado, Javier Sánchez-Ruiz De Gordoa, Janire Vicuña-Urriza, Miren Roldán, Alberto Labarga, María Victoria Zelaya, Carolina Cabello, Iván Méndez-López, Maite Mendioroz
Publikováno v:
Epigenetics, Vol 15, Iss 10, Pp 1083-1092 (2020)
The discovery of new biomarkers would be very valuable to improve the detection of early Alzheimer’s disease (AD). DNA methylation marks may serve as epigenetic biomarkers of early AD. Here we identified epigenetic marks that are present in the hum
Externí odkaz:
https://doaj.org/article/df5e1ff117e44dbeba893ed78f4e8b03
Autor:
Blanca Acha, Jon Corroza, Javier Sánchez-Ruiz de Gordoa, Sara Zueco, Maitane Robles, Iván Méndez-López, Mónica Macías Conde, Carolina Cabello, Miren Roldan, Amaya Urdánoz-Casado, Ivonne Jericó, María Elena Erro, Daniel Alcolea, Alberto LLeó, Idoia Blanco-Luquin, Maite Mendioroz
Background: This work investigated the diagnostic accuracy of a blood-based DNA methylation marker panel as a non-invasive tool to identify Alzheimer's disease (AD) patients. Methods: Blood DNA methylation levels at 46 CpG sites (21 genes selected af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f644fff0b7b50a15900af386136891
https://doi.org/10.21203/rs.3.rs-2385191/v1
https://doi.org/10.21203/rs.3.rs-2385191/v1
Autor:
Iván Méndez-López, Idoia Blanco-Luquin, Javier Sánchez-Ruiz de Gordoa, Amaya Urdánoz-Casado, Miren Roldán, Blanca Acha, Carmen Echavarri, Victoria Zelaya, Ivonne Jericó, Maite Mendioroz
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 878 (2019)
Lamins are fibrillary proteins that are crucial in maintaining nuclear shape and function. Recently, B-type lamin dysfunction has been linked to tauopathies. However, the role of A-type lamin in neurodegeneration is still obscure. Here, we examined A
Externí odkaz:
https://doaj.org/article/eeb75d46ba99462191d059f3dd15ed30
Autor:
María Victoria Zelaya, Miren Roldán, Amaya Urdánoz-Casado, Janire Vicuña-Urriza, Alberto Labarga, Blanca Acha, Idoia Blanco-Luquin, Maite Mendioroz, Javier Sánchez-Ruiz de Gordoa, Iván Méndez-López, Carolina Cabello
Publikováno v:
Epigenetics
The discovery of new biomarkers would be very valuable to improve the detection of early Alzheimer’s disease (AD). DNA methylation marks may serve as epigenetic biomarkers of early AD. Here we identified epigenetic marks that are present in the hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a01a5ca9fc963d5a01635f233ad43f7
https://pubmed.ncbi.nlm.nih.gov/32233750
https://pubmed.ncbi.nlm.nih.gov/32233750
Autor:
Juan Erviti, Iván Méndez‐López, Douglas M Salzwedel, Jose Ignacio Pijoan, Leire Leache, Luis Carlos Saiz, Miguel Menéndez Orenga
Publikováno v:
Cochrane Database Syst Rev
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primary objective To assess the effects of lower or standard blood pressure targets for hypertensive patients with CKD on mortality and morbidity outcomes. 'Lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aada5ee3cffa5c008c899fee5292c3b
https://doi.org/10.1002/14651858.cd008564.pub2
https://doi.org/10.1002/14651858.cd008564.pub2
Autor:
Julie M. J. Lepesant, Carmen Echavarri, Ivonne Jericó, Miren Roldán, Idoia Blanco-Luquin, Iván Méndez-López, Rosa Larumbe, Luisa Di Stefano, Amaya Urdánoz-Casado, Miren Altuna, Álvaro Perdones, María Victoria Zelaya, Alberto Labarga, Maite Mendioroz, Javier Sánchez-Ruiz de Gordoa
Publikováno v:
Clinical Epigenetics
Background Drawing the epigenome landscape of Alzheimer’s disease (AD) still remains a challenge. To characterize the epigenetic molecular basis of the human hippocampus in AD, we profiled genome-wide DNA methylation levels in hippocampal samples f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884019613e1670437f2b6d7d4521d30a
https://pubmed.ncbi.nlm.nih.gov/31217032
https://pubmed.ncbi.nlm.nih.gov/31217032
Publikováno v:
Medicina Clínica (English Edition). 144:457-464
DNA methylation is an epigenetic mechanism that controls gene expression. In Alzheimer's disease (AD), global DNA hypomethylation of neurons has been described in the human cerebral cortex. Moreover, several variants in the methylation pattern of can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ab99b8323f88583ff0b7950d75294f
https://doi.org/10.1016/j.medcle.2015.12.014
https://doi.org/10.1016/j.medcle.2015.12.014
Publikováno v:
Medicina Clínica. 144:457-464
Resumen La metilacion del ADN es un mecanismo epigenetico que controla la expresion genica. En la enfermedad de Alzheimer (EA) se ha encontrado hipometilacion global del ADN en neuronas del cortex cerebral humano. Ademas, se han identificado variacio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a96a2de11731af66f62e98b4e682f3d
https://doi.org/10.1016/j.medcli.2014.03.023
https://doi.org/10.1016/j.medcli.2014.03.023
Autor:
Carmen Echavarri, Ivonne Jericó, Amaya Urdánoz-Casado, Miren Roldán, Iván Méndez-López, Victoria Zelaya, Idoia Blanco-Luquin, Maite Mendioroz, Javier Sánchez-Ruiz de Gordoa, Blanca Acha
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 878 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 4
International Journal of Molecular Sciences
Volume 20
Issue 4
Lamins are fibrillary proteins that are crucial in maintaining nuclear shape and function. Recently, B-type lamin dysfunction has been linked to tauopathies. However, the role of A-type lamin in neurodegeneration is still obscure. Here, we examined A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a1e0aae15a75af7bfa3a873b6ca3d3
https://doi.org/10.3390/ijms20040878
https://doi.org/10.3390/ijms20040878
Autor:
Howard J. Worman, Robert S. Krauss, Wei Wu, Iván Méndez-López, Mingi Hong, Ji Yeon Shin, Leana Shugol, William T. Dauer, Yuexia Wang, Kurenai Tanji
Lamina-associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that has been implicated in striated muscle maintenance. Mutations in its gene have been linked to muscular dystrophy and cardiomyopathy. As germline deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d59105499e1e760af3e6f78d4c43459
https://europepmc.org/articles/PMC6075563/
https://europepmc.org/articles/PMC6075563/