Výsledky vyhledávání - "Iván E. Sierralta"

Trans-Channel Interactions in Batrachotoxin-Modified Skeletal Muscle Sodium Channels: Voltage-Dependent Block by Cytoplasmic Amines, and the Influence of μ-Conotoxin GIIIA Derivatives and Permeant Ions

Autor: Jeffrey R. McArthur, Evgeny Pavlov, Quanli Ma, Gerald W. Zamponi, Tatiana Britvina, Iván E. Sierralta, Robert J. French

Publikováno v: Biophysical Journal. 95(9):4277-4288

External mu-conotoxins and internal amine blockers inhibit each other's block of voltage-gated sodium channels. We explore the basis of this interaction by measuring the shifts in voltage-dependence of channel inhibition by internal amines induced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045766775ace3aa7a2e4c575d8461bcc

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Molecular and kinetic determinants of local anaesthetic action on sodium channels

Autor: Iván E. Sierralta, Gerald W. Zamponi, Robert J. French

Publikováno v: Toxicology Letters. :247-254

(1) Local anaesthetics (LA) rely for their clinical actions on state-dependent inhibition of voltage-dependent sodium channels. (2) Single, batrachoxin-modified sodium channels in planar lipid bilayers allow direct observation of drug-channel interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085de0651b64adcf80cfcde56d2578e3
https://doi.org/10.1016/s0378-4274(98)00192-1

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