Identification of novel antistaphylococcal hit compounds.

Autor: Volynets GP; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine. g.p.volynets@gmail.com., Iungin OS; Department of Functional Genomics, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Gudzera OI; Department of Protein Synthesis Enzymology, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Vyshniakova HV; Laboratory of Medical Microbiology with the Museum of Human Pathogenic Microorganisms, L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases NAMS of Ukraine, 5 Amosova St., Kyiv, 03038, Ukraine., Rybak MY; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555, USA., Moshynets OV; Biofilm study group, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Balanda AO; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Borovykov OV; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Prykhod'ko AO; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine.; Research and Development Department, Scientific Services Company Otava Ltd, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Lukashov SS; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Maiula TH; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine.; Research and Development Department, Scientific Services Company Otava Ltd, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Pletnova LV; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Yarmoluk SM; Department of Medicinal Chemistry, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine., Tukalo MA; Department of Protein Synthesis Enzymology, Institute of Molecular Biology and Genetics, the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine.

Publikováno v: The Journal of antibiotics [J Antibiot (Tokyo)] 2024 Oct; Vol. 77 (10), pp. 665-678. Date of Electronic Publication: 2024 Jun 25.

Azithromycin possesses biofilm-inhibitory activity and potentiates non-bactericidal colistin methanesulfonate (CMS) and polymyxin B against Klebsiella pneumonia.

Autor: Moshynets OV; Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine., Baranovskyi TP; Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.; Kyiv Regional Clinical Hospital, Kyiv, Ukraine., Cameron S; School of Applied Sciences, Abertay University, Dundee, United Kingdom., Iungin OS; Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine.; Kyiv National University of Technologies and Design, Kyiv, Ukraine., Pokholenko I; Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine., Jerdan R; School of Applied Sciences, Abertay University, Dundee, United Kingdom., Kamyshnyi A; I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Krikunov AA; Amosov National Institute of Cardiovascular Surgery, Kyiv, Ukraine., Potochilova VV; Kyiv Regional Clinical Hospital, Kyiv, Ukraine., Rudnieva KL; Kyiv Regional Clinical Hospital, Kyiv, Ukraine., Spiers AJ; School of Applied Sciences, Abertay University, Dundee, United Kingdom.

Publikováno v: PloS one [PLoS One] 2022 Jul 01; Vol. 17 (7), pp. e0270983. Date of Electronic Publication: 2022 Jul 01 (Print Publication: 2022).

eDNA Inactivation and Biofilm Inhibition by the PolymericBiocide Polyhexamethylene Guanidine Hydrochloride (PHMG-Cl).

Autor: Moshynets OV; Biofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine., Baranovskyi TP; Department of Dermatovenerology, Allergology, Clinical and Laboratory Immunology, Shupyk National Healthcare University of Ukraine, 9 Dorohozhytska Str., 03680 Kiev, Ukraine.; Kyiv Regional Clinical Hospital, 1 Baggovutivska Street, 04107 Kiev, Ukraine., Iungin OS; Biofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine.; Department of Biotechnology, Leather and Fur, Faculty of Chemical and Biopharmaceutical Technologies, Kyiv National University of Technologies and Design, Nemyrovycha-Danchenka Street, 2, 01011 Kiev, Ukraine., Kysil NP; National Children's Specialized Hospital 'Okhmatdyt', 28/1 Chornovola Str., 01135 Kiev, Ukraine., Metelytsia LO; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine., Pokholenko I; Biofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine., Potochilova VV; Kyiv Regional Clinical Hospital, 1 Baggovutivska Street, 04107 Kiev, Ukraine., Potters G; Antwerp Maritime Academy, Noordkasteel Oost 6, 2030 Antwerp, Belgium.; Department of Bioscience Engineering, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium., Rudnieva KL; Kyiv Regional Clinical Hospital, 1 Baggovutivska Street, 04107 Kiev, Ukraine., Rymar SY; Biofilm Study Group, Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnoho Str., 03680 Kiev, Ukraine., Semenyuta IV; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine., Spiers AJ; School of Applied Sciences, Abertay University, Bell Street, Dundee DD1 1HG, UK., Tarasyuk OP; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine., Rogalsky SP; V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske Schose, 01135 Kiev, Ukraine.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 10; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 10.