Determining Out-of-Field Doses and Second Cancer Risk From Proton Therapy in Young Patients—An Overview

Autor: Maite Romero-Expósito, Iuliana Toma-Dasu, Alexandru Dasu

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Proton therapy has the potential to provide survival and tumor control outcomes comparable and frequently superior to photon therapy. This has led to a significant concern in the medical physics community on the risk for the induction of second cance

Externí odkaz: https://doaj.org/article/0a97f0b50d8949cd83a5e34ed7348c53

Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours

Autor: Filippo, Schiavo, Iuliana, Toma-Dasu, Emely Kjellsson, Lindblom

Publikováno v: Advances in experimental medicine and biology. 1395

Despite advancements in functional imaging, the resolution of modern techniques is still limited with respect to the tumour microenvironment. Radiotherapy strategies to counteract e.g., tumour hypoxia based on functional imaging therefore carry an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c46795a9f8e6b331c36577becddddb1
https://pubmed.ncbi.nlm.nih.gov/36527645

Cell Type-Specific Patterns in the Accumulation of DNA Damage Following Multifractional Radiation Exposure

Autor: Lundholm, Pamela Akuwudike, Adrianna Tartas, Milagrosa López-Riego, Iuliana Toma-Dasu, Andrzej Wojcik, Lovisa

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12861

Predicting the risk of second malignant neoplasms is complicated by uncertainties regarding the shape of the dose–response relationship at high doses. Limited understanding of the competitive relationship between cell killing and the accumulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::198711d5f17a8eee0517e7b51d4988e2

Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy

Autor: Fredrik Kalholm, Leszek Grzanka, Iuliana Toma‐Dasu, Niels Bassler

Publikováno v: Kalholm, F, Grzanka, L, Toma-Dasu, I & Bassler, N 2023, ' Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy ', Medical Physics, vol. 50, no. 1, pp. 651-659 . https://doi.org/10.1002/mp.16029

Background: For proton therapy, a relative biological effectiveness (RBE) of 1.1 has broadly been applied clinically. However, as unexpected toxicities have been observed by the end of the proton tracks, variable RBE models have been proposed. Typica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1c00aaaa4938433f3f7f47d23657f7
https://pubmed.ncbi.nlm.nih.gov/36321465

Benign-malignant pulmonary nodule classification in low-dose CT with convolutional features

Autor: Yousuf Zakko, Mehdi Astaraki, Chunliang Wang, Örjan Smedby, Iuliana Toma Dasu

Publikováno v: Physica Medica. 83:146-153

Purpose Low-Dose Computed Tomography (LDCT) is the most common imaging modality for lung cancer diagnosis. The presence of nodules in the scans does not necessarily portend lung cancer, as there is an intricate relationship between nodule characteris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba97bb20f2299c8e3d686153af13f6a
https://doi.org/10.1016/j.ejmp.2021.03.013