Determining Out-of-Field Doses and Second Cancer Risk From Proton Therapy in Young Patients—An Overview

Autor: Maite Romero-Expósito, Iuliana Toma-Dasu, Alexandru Dasu

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Proton therapy has the potential to provide survival and tumor control outcomes comparable and frequently superior to photon therapy. This has led to a significant concern in the medical physics community on the risk for the induction of second cance

Externí odkaz: https://doaj.org/article/0a97f0b50d8949cd83a5e34ed7348c53

Cell Type-Specific Patterns in the Accumulation of DNA Damage Following Multifractional Radiation Exposure

Autor: Pamela Akuwudike, Adrianna Tartas, Milagrosa López-Riego, Iuliana Toma-Dasu, Andrzej Wojcik, Lovisa Lundholm

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 21, p 12861 (2022)

Predicting the risk of second malignant neoplasms is complicated by uncertainties regarding the shape of the dose–response relationship at high doses. Limited understanding of the competitive relationship between cell killing and the accumulation o

Externí odkaz: https://doaj.org/article/5f585bd9275b42f1abc89c08afa3a37a

Photon and Proton Dose Painting Based on Oxygen Distribution - Feasibility Study and Tumour Control Probability Assessment

Autor: Ana, Ureba, Jakob, Ödén, Iuliana, Toma-Dasu, Marta, Lazzeroni

Publikováno v: Advances in experimental medicine and biology. 1395

Solid tumours may present hypoxic sub-regions of increased radioresistance. Hypoxia quantification requires of clinically implementable, non-invasive and reproducible techniques as positron emission tomography (PET). PET-based dose painting strategie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa9441488d7708a7a5b398c880dea678
https://pubmed.ncbi.nlm.nih.gov/36527641

BIOLOGICAL EFFECTIVENESS OF STEREOTACTIC RADIOTHERAPY INCREASES WITH FRACTIONATION IN HYPOXIC TUMORS

Autor: Mr Filippo Schiavo, Emely Kjellsson Lindblom, Pierre Barsoum, Alexandru Dasu, Iuliana Toma-Dasu

Publikováno v: Physica Medica. 104:S8-S9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdce5b89fc47cf7168c67e3c64df97f0
https://doi.org/10.1016/s1120-1797(22)02132-9

Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy

Autor: Fredrik Kalholm, Leszek Grzanka, Iuliana Toma‐Dasu, Niels Bassler

Publikováno v: Kalholm, F, Grzanka, L, Toma-Dasu, I & Bassler, N 2023, ' Modeling RBE with other quantities than LET significantly improves prediction of in vitro cell survival for proton therapy ', Medical Physics, vol. 50, no. 1, pp. 651-659 . https://doi.org/10.1002/mp.16029

Background: For proton therapy, a relative biological effectiveness (RBE) of 1.1 has broadly been applied clinically. However, as unexpected toxicities have been observed by the end of the proton tracks, variable RBE models have been proposed. Typica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1c00aaaa4938433f3f7f47d23657f7
https://pubmed.ncbi.nlm.nih.gov/36321465