Výsledky vyhledávání - "Iulian I Oprea"

Akademický článek

Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression

Autor: Iulian I Oprea, Joana R Viola, Pedro M D Moreno, Oscar E Simonson, Sergey Rodin, Nathalie Teller, Karl Tryggvason, Karin E Lundin, Leonard Girnita, Carl Inge Edvard Smith

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)

Inducible systems for gene expression emerge as a new class of artificial vectors offering temporal and spatial exogenous control of gene expression. However, most inducible systems are less efficient in vivo and lack the target-organ specificity. In

Externí odkaz: https://doaj.org/article/502466cfc7d34aeebe0b6b19531e8534

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Progresses towards safe and efficient gene therapy vectors

Autor: Sergiu Chira, George A. Calin, Carlo Stephan Jackson, Iulian I. Oprea, Ferhat Ozturk, Iulia Diaconu, Cornelia Braicu, Ioana Berindan-Neagoe, Michael S. Pepper, Lajos-Zsolt Raduly

Publikováno v: Oncotarget

The emergence of genetic engineering at the beginning of the 1970′s opened the era of biomedical technologies, which aims to improve human health using genetic manipulation techniques in a clinical context. Gene therapy represents an innovating and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ddc85b9e0b5bf1e32f8aa40c9368f7
https://doi.org/10.18632/oncotarget.5169

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Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes

Autor: George A. Calin, Ada Girnita, Caitrin Crudden, Iulian I. Oprea, C. Worrall, Leonard Girnita, Takashi Shibano, Naida Suleymanova, Andrei Adrian Tica

Publikováno v: Oncogene, 36(41), 5734-5744. Nature Publishing Group
Oncogene
Suleymanova, N, Crudden, C, Shibano, T, Worrall, C, Oprea, I, Tica, A, Calin, G A, Girnita, A & Girnita, L 2017, ' Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes ', Oncogene, vol. 36, no. 41, pp. 5734-5744 . https://doi.org/10.1038/onc.2017.179

With very similar 3D structures, the widely expressed β-arrestin isoforms 1 and 2 play at times identical, distinct or even opposing roles in regulating various aspects of G protein-coupled receptors (GPCR) expression and signalling. Recent evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f65780f95d847475bc16444301bc124
https://research.vumc.nl/en/publications/83b489c7-4c33-4af1-8eaa-8390e566d47f

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Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA

Autor: Y. Vladimir Pabon, Burcu Bestas, Sylvain Geny, Samir El Andaloussi, Rula Zain, C. I. Edvard Smith, Per T. Jørgensen, Jesper Wengel, Eman M. Zaghloul, Cristina S. J. Rocha, Helen Bergquist, Iulian I. Oprea, Erik B. Pedersen, Pedro Moreno, Karin E. Lundin

Publikováno v: Moreno, P M D, Geny, S, Pabon, Y V, Bergquist, H, Zaghloul, E M, Rocha, C S J, Oprea, I I, Bestas, B, Andaloussi, S E, Jørgensen, P T, Pedersen, E B, Lundin, K E, Zain, R, Wengel, J & Smith, C I E 2013, ' Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA ', Nucleic Acids Research, vol. 41, no. 5, pp. 3257-3273 . https://doi.org/10.1093/nar/gkt007
Nucleic Acids Research
Nucleic Acids Research; Vol 41

In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33c536d31a11df21278a74d1e527aa4
https://doi.org/10.1093/nar/gkt007

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β-Arrestin–biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor–targeting antibodies in Ewing’s sarcoma

Autor: Ada Girnita, C. Worrall, Iulian I. Oprea, Hongchang Shen, Radu Stefanescu, H. Zheng, Leonard Girnita

Publikováno v: Proceedings of the National Academy of Sciences. 109:20620-20625

Owing to its essential role in cancer, insulin-like growth factor type 1 receptor (IGF-1R)–targeted therapy is an exciting approach for cancer treatment. However, when translated into clinical trials, IGF-1R–specific antibodies did not fulfill ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f808f6092dc6f36f96c32874064150
https://doi.org/10.1073/pnas.1216348110

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Optimizing anti-gene oligonucleotide ‘Zorro-LNA’ for improved strand invasion into duplex DNA

Autor: Samir El-Andaloussi, C. I. Edvard Smith, Pankaj Gupta, Pedro Moreno, Jesper Wengel, Andreas Stahl Madsen, Eman M. Zaghloul, Karin E. Lundin, Erik B. Pedersen, Iulian I. Oprea, Burcu Bestas

Publikováno v: Nucleic Acids Research
Zaghloul, E M, Madsen, A S, Moreno, P M D, Oprea, I I, El-Andaloussi, S, Bestas, B, Gupta, P, Pedersen, E B, Lundin, K E, Wengel, J & Smith, C I E 2011, ' Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA ', Nucleic Acids Research, vol. 39, no. 3, pp. 1142-54 . https://doi.org/10.1093/nar/gkq835

Zorro-LNA (Zorro) is a newly developed, oligonucleotide (ON)-based, Z-shaped construct with the potential of specific binding to each strand of duplex DNA. The first-generation Zorros are formed by two hybridized LNA/DNA mixmers (2-ON Zorros) and was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5388a96d8f9bc6ed97aa4406c7d49c
http://europepmc.org/articles/PMC3035455

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Temperature-Assisted Cyclic Hybridization (TACH): An Improved Method for Supercoiled DNA Hybridization

Autor: Oscar E. Simonson, Joana R Viola, Pedro Moreno, C. I. Edvard Smith, Karin E. Lundin, Iulian I. Oprea

Publikováno v: Molecular Biotechnology. 45:171-179

Accurate hybridization is dependent on the ratio between sequence-specific and unspecific binding. Dissociation of unspecifically bound, while maintaining specifically hybridized, nucleic acids are key steps to obtain a well-defined complex. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1456d51bc2a9e82e12a8e9387f62f2e
https://doi.org/10.1007/s12033-010-9261-x

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Nanotechnology approaches for gene transfer

Autor: Karin E. Lundin, Iulian I. Oprea, Mathias G. Svahn, Pedro Moreno, C. I. Edvard Smith, Oscar E. Simonson, Eman M. Zaghloul

Publikováno v: Genetica. 137:47-56

In both basic research as well as experimental gene therapy the need to transfer genetic material into a cell is of vital importance. The cellular compartment, which is the target for the genetic material, depends upon application. An siRNA that medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e269cde12abbfb5e75c2e03e64d9561b
https://doi.org/10.1007/s10709-009-9372-0

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