Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis.

Autor: Florian Georgescauld, Lucile Moynié, Johann Habersetzer, Laura Cervoni, Iulia Mocan, Tudor Borza, Pernile Harris, Alain Dautant, Ioan Lascu

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e57867 (2013)

Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing. The quaternary structure

Externí odkaz: https://doaj.org/article/9c4941e5b62e43ea9a9b1fc3572e125e

Protein phosphorylation corrects the folding defect of the neuroblastoma (S120G) mutant of human nucleoside diphosphate kinase A/Nm23-H1

Autor: Laura Cervoni, Sandrine Dabernat-Arnaud, Ioan Lascu, Iulia Mocan, Anna Giartosio, Philippe Gonin, Marie-Lise Lacombe, Marc Crouzet, Florian Georgescauld, Didier Thoraval

Publikováno v: Biochemical Journal. 403:149-156

Human nucleoside diphosphate (NDP) kinase A is a ‘house-keeping’ enzyme essential for the synthesis of nonadenine nucleoside (and deoxynucleoside) 5′-triphosphate. It is involved in complex cellular regulatory functions including the control of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a428eff78b209af7804ad76d18c0229
https://doi.org/10.1042/bj20061141

Helicobacter pullorum cytolethal distending toxin targets vinculin and cortactin and triggers formation of lamellipodia in intestinal epithelial cells

Autor: Belgacem Mihi, Iulia Mocan, François Doignon, David Laharie, Christine Moraté, Francis Mégraud, Christine Varon, Christelle Péré-Védrenne, Mónica Oleastro, Armelle Ménard, Anriette Aboubacar

Publikováno v: The Journal of infectious diseases. 209(4)

Helicobacter pullorum, a bacterium initially isolated from poultry, has been associated with human digestive disorders. However, the factor responsible for its cytopathogenic effects on epithelial cells has not been formally identified. The cytopatho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0395066cebc7cd3bcae7729f1ba27dd5
https://pubmed.ncbi.nlm.nih.gov/24470577

Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis

Autor: Lucile Moynié, Laura Cervoni, Iulia Mocan, Pernile Harris, Johann Habersetzer, Tudor Borza, Florian Georgescauld, Ioan Lascu, Alain Dautant

Publikováno v: Georgescauld, F, Moynie, L, Habersetzer, J, Cervoni, L, Mocan, I, Borza, T, Harris, P H, Dautant, A & Lascu, I 2013, ' Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis ', P L o S One, vol. 8, no. 3, e57867 . https://doi.org/10.1371/journal.pone.0057867
'PloS One ', vol: 8, pages: e57867-1-e57867-11 (2013)
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e57867. ⟨10.1371/journal.pone.0057867⟩
PLoS ONE, Vol 8, Iss 3, p e57867 (2013)

International audience; Most nucleoside diphosphate kinases (NDPKs) are hexamers. The C-terminal tail interacting with the neighboring subunits is crucial for hexamer stability. In the NDPK from Mycobacterium tuberculosis (Mt) this tail is missing. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9312a1fa42fbf782b7d65cb39179e476
https://curis.ku.dk/ws/files/118588199/journal.pone.0057867.pdf

Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease

Autor: Antoine Toubert, Nicolas Dulphy, Benjamin Pariente, Julien Ettersperger, Charles-Antoine Dutertre, Matthieu Allez, Iulia Mocan, Marc Lémann, Matthieu Camus, Pierre Cattan, Jean Marc Gornet, Dominique Charron

Publikováno v: Gastroenterology. 141(1)

Background & Aims The natural killer group 2 member D (NKG2D) is a stimulatory receptor expressed on a subset of mucosal and peripheral CD4 + T cells in patients with Crohn's disease (CD) and other inflammatory diseases. Ligand activation of NKG2D in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd85f84b4e0a514c0562ae621eb0a65
https://pubmed.ncbi.nlm.nih.gov/21600899