Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Iula Donna Michele"'
Autor:
Karen Elaine Sexton, Venkataraman Thanabal, Ann McCarthy, Leroy Lu, Erli Zhang, Maria N. Nguyen, Downs Victoria Leigh, Paul R. Keller, Mark L. Boys, Richard Gowan, Patrick I. McConnell, Edmund L. Ellsworth, Neil Raheja, Richard B. Gilbertsen, Hena Mostafa, Filzen Gary Frederick, N. A. Payne, Feng Bian, Huifen Chen, John D. Knafels, Samarendra N. Maiti, Elena M. Drummond, Stephen Douglas Barrett, Zhi Wang, Larry D. Bratton, Diane Alessi, Deepak S. Lala, Stephen Fakhoury, Sneha Patel, Barry C. Finzel, Susan Ciotti, Iula Donna Michele, Fang Sun, Paul Angell, Xiao Dan Ren, David Pocalyko, Rone Eisma, Kramer James Bernard, Catherine R. Kostlan, Christopher L. Chio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3392-3397
A series of 2-(1H-pyrazol-1-yl)pyridines are described as inhibitors of ALK5 (TGFβ receptor I kinase). Modeling compounds in the ALK5 kinase domain enabled some optimization of potency via substitutions on the pyrazole core. One of these compounds P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632fe42ba8bb00febbc77151eb92bc8f
https://doi.org/10.1016/j.bmcl.2012.04.013
https://doi.org/10.1016/j.bmcl.2012.04.013
Autor:
Jie Jack Li, Lain-Yen Hu, Mark Lovdahl, Daniel Y. Du, Brian Samas, Iula Donna Michele, Mark L. Boys, Garrett S. Hoge, Elena M. Drummond, Matthew Carroll, Danielle Dettling, William Glen Harter, Veerabahu Shanmugasundaram, Jeffrey Asbill, Maria N. Nguyen, Theresa Krieger-Burke, Wen-Song Yue, Bruce Allen Lefker, Susan Ciotti, Kimberly Jane Wade, Zhi Wang, Theodore R. Johnson, Jennifer A. Van Camp, Mary Ann Meade
Publikováno v:
Journal of Medicinal Chemistry. 51:7010-7014
4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd56ef08bd905300c38ac78afc3cbfd
https://doi.org/10.1021/jm8009316
https://doi.org/10.1021/jm8009316
Autor:
Lorna Helen Mitchell, Bruce Allen Lefker, Stephen Fakhoury, Catherine R. Kostlan, Iula Donna Michele, Maria Nguyen, Lain-Yen Hu, Daniel Du, David Pocalyko, Danielle Dettling, Kimberly Jane Wade, Matthew Carroll, Smith Yvonne Dorothy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2176-2178
A series of diphenyl ethers was prepared and evaluated for androgen receptor antagonist activity in human androgen receptor binding and cellular functional assays. Analogs with potent in vitro activities were evaluated for topical in vivo efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c1a869805018aeb7cad68285ff9ec5
https://doi.org/10.1016/j.bmcl.2009.02.104
https://doi.org/10.1016/j.bmcl.2009.02.104