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pro vyhledávání: '"Iu V, Krasotkina"'
Publikováno v:
Biomeditsinskaia khimiia. 54(4)
Asparaginase from Helicobacterpylori has been cloned and expressed in E. coli cells. Optimization of culturing and expression conditions allowed achieving stable synthesis of catalytically active asparaginase amounting up to 6% of total bacterial pro
Publikováno v:
Biomeditsinskaia khimiia. 53(1)
A method for polyethylene conjugation with recombinant asparaginase has been developed to improve therapeutically important properties of this enzyme. Methoxy-nitrophenyl carbamate of polyethylene glycol with molecular weight 5000 was employed as the
Publikováno v:
Biomeditsinskaia khimiia. 52(3)
Bacterial L-asparaginases catalyzing hydrolysis of L-asparagine up to L-aspartate and ammonia, are used in medical practice for treatment of acute lymphoblastic leukemia. The long-term therapy with these preparations is accompanied by a number of sid