Výsledky vyhledávání - "Iu A, Sharkin"

2'fluoro derivatives of nucleosides as substrates of viral replicative nucleotide polymerases

Autor: M K, Kukhanova, A N, Korovina, Iu A, Sharkin, A V, Azhaev, S N, Kochetkov

Publikováno v: Molekuliarnaia biologiia. 48(5)

Substrate specificities of three viral replicative polymerases of different origins (HIV reverse transcriptase, hepatitis C virus RNA polymerase, and herpes virus DNA polymerase) towards 2'F-NTP were studied. Activated DNA, polyA-oligoUs and (2'F-A)2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8efa3c3e78854badeaef01785e58c64
https://pubmed.ncbi.nlm.nih.gov/25842869

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[Synthesis and substrate properties of modified nucleoside 5'-triphosphates mimicking dATP in the reactions of DNA synthesis catalyzed by DNA polymerases]

Autor: Iu A, Sharkin, D G, Semizarov, L S, Viktorova, M K, Kukhanova

Publikováno v: Bioorganicheskaia khimiia. 27(5)

Several modified nucleoside 5'-triphosphates were synthesized containing adenine-mimicking pyrimidine derivatives as an aglycone. The study of substrate properties of these compounds towards DNA-synthesizing enzymes showed their ability of being inco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0906498f0c9c7937a6509b04bfd0003d
https://pubmed.ncbi.nlm.nih.gov/11641913

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[Purine arabinonucleoside-5'-triphosphates with substituents in the 2'-position as DNA polymerase substrates]

Autor: Iu A, Sharkin, E V, Kuznetsova, L S, Viktorova, L A, Aleksandrova

Publikováno v: Molekuliarnaia biologiia. 29(4)

Analogues of araNTPs carrying an azido or aminogroup instead of the 2' hydroxyl exhibited substrate properties towards several mammalian and viral DNA polymerases. At the same time, introduction of a bulky hydrophobic DNP group into the 2' position i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df38369beca0fa460d00a95d7e210413
https://pubmed.ncbi.nlm.nih.gov/7476957

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