Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1

Autor: Itziar M. D. Posada, Benoit Lectez, Farid A. Siddiqui, Christina Oetken-Lindholm, Mukund Sharma, Daniel Abankwa

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract As a major growth factor transducer, Ras is an upstream activator of mTORC1, which further integrates nutrient and energy inputs. To ensure a contextual coupling of cell division via Ras/MAPK-signalling and growth via mTORC1-signalling, feed

Externí odkaz: https://doaj.org/article/37bdb60d533147c484ba87879ea57fcb

Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1

Autor: Christina Oetken-Lindholm, Mukund Sharma, Farid Ahmad Siddiqui, Daniel Abankwa, Itziar M. D. Posada, Benoit Lectez

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports. London, United Kingdom: Nature Publishing Group (2017).
Scientific Reports

As a major growth factor transducer, Ras is an upstream activator of mTORC1, which further integrates nutrient and energy inputs. To ensure a contextual coupling of cell division via Ras/MAPK-signalling and growth via mTORC1-signalling, feedback loop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f163e56b3e4eb2cfb1cc9bb280983e
https://doaj.org/article/37bdb60d533147c484ba87879ea57fcb

Abstract B29: SHANK3 in oncogenic RAS signaling

Autor: Igor L. Barsukov, Hans-Juergen Kreienkamp, Guillaume Jcaquement, Johanna Ivaska, Itziar M. D. Posada, Ella-Maria Vesilahti, Petra Laasola, Mitro Miihkinen, Siiri I. Salomaa, Daniel Abankwa, Johanna Lilja

Publikováno v: Molecular Cancer Research. 18:B29-B29

RAS proteins play a direct causal role in human cancers, with activating mutations in RAS occurring in ∼30% of tumors. Despite comprehensive efforts, efficient targeting of RAS has not yet reached the clinic. Here, we report SHANK3, a synaptic scaf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::244341b1006f7fb18d179c19d4d067e4
https://doi.org/10.1158/1557-3125.ras18-b29

ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold

Autor: Yong Zhou, Christina Oetken-Lindholm, Daniel Abankwa, Benoit Lectez, Itziar M. D. Posada, Marc Serulla

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159677 (2016)
PLoS ONE

Ras-induced senescence mediated through ASPP2 represents a barrier to tumour formation. It is initiated by ASPP2’s interaction with Ras at the plasma membrane, which stimulates the Raf/MEK/ERK signaling cascade. Ras to Raf signalling requires Ras t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471f689f1d2ddfa4c4b39d3a63768d71
http://europepmc.org/articles/PMC4954646?pdf=render

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers

Autor: Yong Zhou, Adyary Fallarero, Pia Vuorela, Itziar M. D. Posada, Benoit Lectez, Arafath Kaja Najumudeen, Daniel Abankwa, John F. Hancock, Sebastian K.-J. Landor

Publikováno v: Biochemistry. 54(49)

Ras isoforms H-, N-, and K-ras are each mutated in specific cancer types at varying frequencies and have different activities in cell fate control. On the plasma membrane, Ras proteins are laterally segregated into isoform-specific nanoscale signalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1872a24e97f144e3d1ecac4c9378b6c
https://pubmed.ncbi.nlm.nih.gov/26568031