Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Itzhak Goldwaser"'
Autor:
Itzhak Goldwaser, Eli Rochlin, Ronald Ellis, Sarit Samira, Yechezkel Barenholz, Orli Even-Or, Jack Spira, Shobana Balasingam, Alex Mann, Rob Lambkin-Williams
Publikováno v:
Vaccine. 28:6527-6541
We optimized the immunogenicity of adjuvanted seasonal influenza vaccine based on commercial split influenza virus as an antigen (hemagglutinin = HA) and on a novel polycationic liposome as a potent adjuvant and efficient antigen carrier (CCS/C-HA va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5c1c4deecd0fc0d07a95a88a0ece3c
https://doi.org/10.1016/j.vaccine.2010.04.011
https://doi.org/10.1016/j.vaccine.2010.04.011
Publikováno v:
Pure and Applied Chemistry. 77:1617-1628
We report that oral administration of vanadium (+5) combined with L-glutamic acid γ-monohydroxamate at 1:2 stoichiometry [L-Glu(γ)HXM.VO3 -] is highly effective in reducing blood glucose levels (BGLs) in a wide variety of diabetic rodents. In strep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b98902878c48125da5b7f0d9a8ce47
https://doi.org/10.1351/pac200577091617
https://doi.org/10.1351/pac200577091617
Publikováno v:
Coordination Chemistry Reviews. 237:3-11
Intensive studies have been carried out during the last two decades, on the insulinomimetic effects of vanadium. Vanadium compounds mimic most of the metabolic effects of insulin on the main tissues of the hormone in vitro. Vanadium therapy induces n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b7c2134d4052f2289de6781beb5279
https://doi.org/10.1016/s0010-8545(02)00302-8
https://doi.org/10.1016/s0010-8545(02)00302-8
Publikováno v:
Letters in Peptide Science. 9:235-254
L-glutamic acid (γ) monohydroxamate (L-Glu(γ)HXM) enhances the insulinomimetic activity of vanadium ions both in vitro and in vivo. Based on this ligand as a lead compound, and in order to delineate molecular features relevant to its anti-diabetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3fdb50bbdc1abae28c6f75369998003
https://doi.org/10.1007/bf02447549
https://doi.org/10.1007/bf02447549
Publikováno v:
Journal of Inorganic Biochemistry. 80:21-25
Most mammalian cells contain vanadium at a concentration of about 20 nM, the bulk of which is probably in the reduced vanadyl (+4) form. Although this trace element is essential and should be present in the diet in minute quantities, no known physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660162a3084f2365bc20e6abc3de7a6f
https://doi.org/10.1016/s0162-0134(00)00035-0
https://doi.org/10.1016/s0162-0134(00)00035-0
Autor:
Eytan Gershonov, Michal Armoni, Mati Fridkin, Yoram Shechter, Itzhak Goldwaser, Eddy Karnieli, Jinping Li
Publikováno v:
Journal of Biological Chemistry. 274:26617-26624
We report that the vanadium ligandl-Glu(γ)HXM potentiates the capacity of free vanadium ions to activate glucose uptake and glucose metabolism in rat adipocytes in vitro (by 4–5-fold) and to lower blood glucose levels in hyperglycemic rats in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88390d3a0420a47de30343cb1c735b8c
https://doi.org/10.1074/jbc.274.37.26617
https://doi.org/10.1074/jbc.274.37.26617
Publikováno v:
Journal of medicinal chemistry. 43(13)
In this study we designed, prepared, and analyzed a water-soluble, long-acting insulin derivative whose protracted action in vivo is based on a new principle rather than on slower absorption rates of suspended insulin formulations. To this end, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4313fa94ba48538f49582e2b5eec31c7
https://pubmed.ncbi.nlm.nih.gov/10891112
https://pubmed.ncbi.nlm.nih.gov/10891112
Autor:
Mati Fridkin, L.P. Pratt, Eytan Gershonov, Marina Mironchik, I. Lavon, B. Mester, Yoram Shechter, Itzhak Goldwaser
Publikováno v:
Drugs of the Future. 26:0669
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27f2b198df045f36c046a89a7e94343
https://doi.org/10.1358/dof.2001.026.07.858711
https://doi.org/10.1358/dof.2001.026.07.858711
Autor:
Natesampillai Sekar, Mati Fridkin, Yoram Shechter, Qian Sun, Itzhak Goldwaser, Eytan Gershonov
Publikováno v:
Scopus-Elsevier
Vanadate mimics the metabolic actions of insulin. In diabetic rodents, vanadate also sensitizes peripheral tissues to insulin. We have analyzed whether this latter effect is brought about by a mechanism other than the known insulinomimetic actions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badeaa5b6c3abdd03c609d206a2fe262
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033851024&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033851024&partnerID=MN8TOARS
Publikováno v:
Scopus-Elsevier
Several ligands, when complexed with vanadium, potentiate its insulinomimetic activity both in vivo and in vitro. We have recently found that L-Glu-gamma-monohydroxamate (HXM) and L-Asp(beta)HXM were especially potent in this regard. In the present s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f04e6970234815c7a9760896fa8d24
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033802966&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0033802966&partnerID=MN8TOARS