Solid-state analysis of amorphous solid dispersions: Why DSC and XRPD may not be regarded as stand-alone techniques

Autor: Bjorn Vergauwen, Christophe Huygens, Timothy Pas, Guy Van den Mooter, Sien Dedroog

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 178:112937

Amorphous solid dispersions (ASDs) are single-phase amorphous systems, where drug molecules are molecularly dispersed (dissolved) in a polymer matrix. The molecular dispersion of the drug molecules is responsible for their improved dissolution proper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8881369f6c02ae4e93135ed03949de05
https://doi.org/10.1016/j.jpba.2019.112937

Exploring the feasibility of the use of biopolymers as a carrier in the formulation of amorphous solid dispersions - Part I: Gelatin.

Autor: Pas T; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium., Vergauwen B; Rousselot bvba, Expertise Center, Meulestedekaai 81, 9000 Gent, Belgium., Van den Mooter G; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium. Electronic address: Guy.vandenmooter@kuleuven.be.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2018 Jan 15; Vol. 535 (1-2), pp. 47-58. Date of Electronic Publication: 2017 Oct 31.