O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition

Autor: Gondane, A, Poulose, N, Walker, S, Mills, IG, Itkonen, HM

Publikováno v: Gondane, A, Poulose, N, Walker, S, Mills, I G & Itkonen, H M 2022, ' O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition ', Glycobiology, vol. 32, no. 9, pp. 751–759 . https://doi.org/10.1093/glycob/cwac038

Co-targeting of O-GlcNAc transferase (OGT) and the transcriptional kinase cyclin-dependent kinase 9 (CDK9) is toxic to prostate cancer cells. As OGT is an essential glycosyltransferase, identifying an alternative target showing similar effects is of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0278472963aab0895f4c15c16c09b545
http://hdl.handle.net/10138/347683

Compromised CDK12 activity causes dependency on the high activity of O-GlcNAc transferase.

Autor: Pallasaho S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Gondane A; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Kutz J; Project group Biochemistry, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena D-07745, Germany., Liang J; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Yalala S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland., Duveau DY; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, United States., Pospiech H; Project group Biochemistry, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena D-07745, Germany.; University Hospital and Medical Faculty of the Heinrich-Heine University Düsseldorf, Life Science Center, Düsseldorf D-40225, Germany., Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, United States.; Lymphoid Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, United States., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York 10021, United States.; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, United States.; The New York Genome Center, New York, New York 10013, United States., Itkonen HM; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York 10021, United States.

Publikováno v: Glycobiology [Glycobiology] 2024 Oct 03. Date of Electronic Publication: 2024 Oct 03.

Emerging frontiers in androgen receptor research for prostate Cancer: insights from the 2nd international androgen receptor Symposium.

Autor: Israel JS; Department of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Marcelin LM; Department of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Thomas C; Department of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Szczyrbová E; Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, 779 00, Czech Republic., Fuessel S; Department of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Puhr M; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria., Linxweiler J; Department of Urology, Saarland University, Homburg/Saar, Germany., Yalala S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Zwart WT; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Baniahmad A; Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany., van Goubergen J; Department of Urology, Medical University of Innsbruck, Innsbruck, Austria., Itkonen HM; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Sharp A; Institute of Cancer Research, Sutton, Surrey, UK., O'Neill E; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Pretze M; Institut für Radiopharmazie, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, D-01328, Dresden, Germany., Miederer M; Department of Translational Imaging in Oncology, National Center for Tumor Diseases (NCT/UCC) Dresden: Faculty of Medicine and University Hospital Carl Gustav Carus, University of Technology Dresden (TUD), German Cancer Research Center (DKFZ) Heidelberg, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany., Erb HHH; Department of Urology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. holger.erb@uniklinikum-dresden.de.; Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany. holger.erb@uniklinikum-dresden.de.; Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. holger.erb@uniklinikum-dresden.de.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jul 17; Vol. 43 (1), pp. 194. Date of Electronic Publication: 2024 Jul 17.

Castration-resistant prostate cancer cells are dependent on the high activity of CDK7.

Autor: Pallasaho S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, PL 63 (Haartmaninkatu 8), 00014, Helsinki, Finland., Gondane A; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, PL 63 (Haartmaninkatu 8), 00014, Helsinki, Finland., Kuivalainen A; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, PL 63 (Haartmaninkatu 8), 00014, Helsinki, Finland., Girmay S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, PL 63 (Haartmaninkatu 8), 00014, Helsinki, Finland., Moestue S; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.; Department of Pharmacy, Nord University, Namsos, Bodø, Norway., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.; The New York Genome Center, New York, NY, USA., Itkonen HM; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, PL 63 (Haartmaninkatu 8), 00014, Helsinki, Finland. h.m.itkonen@gmail.com.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA. h.m.itkonen@gmail.com.

Publikováno v: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Jul; Vol. 149 (8), pp. 5255-5263. Date of Electronic Publication: 2022 Nov 18.

O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage.

Autor: Gondane A; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Girmay S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Helevä A; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Pallasaho S; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.; The New York Genome Center, New York, NY, USA., Itkonen HM; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. h.m.itkonen@gmail.com.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, USA. h.m.itkonen@gmail.com.

Publikováno v: Journal of biomedical science [J Biomed Sci] 2022 Feb 14; Vol. 29 (1), pp. 13. Date of Electronic Publication: 2022 Feb 14.